Effects of roundabout on growth cone dynamics, filopodial length, and growth cone morphology at the midline and throughout the neuropile

Journal of Neuroscience

Volumn 19, Issue 18, 1999, Pages 7901-7912

  Murray, Michael J ^a,b   Whitington, Paul M ^a  

^a UNIVERSITY OF NEW ENGLAND   (Australia)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Drosophila melanogaster; Filopodia; Growth cone; Repulsion; Roundabout; Time lapse

Indexed keywords

ARTICLE; DROSOPHILA; EMBRYO; GENE EXPRESSION; GLIA; GROWTH CONE; MOTONEURON; MUTANT; NERVE FIBER; NERVE FIBER GROWTH; NERVE PROJECTION; NEUROPIL; NONHUMAN; PRIORITY JOURNAL;

EID: 0033568858     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-18-07901.1999     Document Type: Article

References (24)

1. Bentley D, O'Connor TP (1994) Cytoskeletal events in growth cone steering. Curr Opin Neurobiol 4:43-48.
2. Brose K, Bland KS, Wang KH, Arnott D, Henzel W, Goodman CS, Tessier-Lavigne M, Kidd T (1999) Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell 96:795-806.
3. Fan J, Raper JA (1995) Localized collapsing cues can steer growth cones without inducing their full collapse. Neuron 14:263-274.
4. Gertler FB, Comer AR, Juang J, Ahern SM, Clark MJ, Liebl EC, Hoffmann FM (1995) enabled, a dosage-sensitive suppressor of mutations in the Drosophila AbI tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties. Genes Dev 9:521-533.
5. Hu S, Reichardt LF (1999) From membrane to cytoskeleton: enabling a connection. Neuron 22:419-422.
6. Kapfhammer JP, Raper JA (1987) Collapse of growth cone structure on contact with specific neurites in culture. J Neurosci 7:201-212.
7. Kidd T, Brose K, Mitchell KJ, Fetter RD, Tessier-Lavigne M, Goodman CS, Tear G (1998a) roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. Cell 92:205-215.
8. Kidd T, Russell C, Goodman CS, Tear G (1998b) Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline. Neuron 20:25-33.
9. Kidd T, Bland KS, Goodman CS (1999) Slit is the midline repellent for the Robo receptor in Drosophila. Cell 96:785-794.
10. Kolodziej PA, Jan LY, Jan YN (1995) Mutations that affect the length, fasciculation, or ventral orientation of specific sensory axons in the Drosophila embryo. Neuron 15:273-286.
11. Li H, Chen J, Wu W, Fagaly T, Zhou L, Yuan W, Dupuis S, Jiang Z, Nash W, Gick C, Ornitz DM, Wu JY, Rao Y (1999) Vertebrate Slit, a secreted ligand for the transmembrane protein Roundabout, is a repellent for olfactory bulb axons. Cell 96:807-818.
12. Lin CH, Forscher P (1993) Cytoskeletal remodeling during growth cone-target interactions. J Cell Biol 121:1369-1383.
13. Lin CH, Espreafico EM, Mooseker MS, Forscher P (1996) Myosin drives retrograde F-actin flow in neuronal growth cones. Neuron 16:769-782.
14. Murray MJ, Merritt DM, Brand AH, Whitington PM (1998) In vivo dynamics of axon guidance in the Drosophila embryo: a time-lapse study of an identified motorneuron. J Neurobiol 37:607-621.
15. O'Connor TP, Bentley D (1993) Accumulation of actin in subsets of pioneer growth cone filopodia in response to neural and epithelial guidance cues in situ. J Cell Biol 123:935-948.
16. O'Connor TP, Duerr JS, Bentley D (1990) Pioneer growth cone steering decisions mediated by single filopodial contacts in situ. J Neurosci 10:3935-3946.
17. Patel NH (1994) Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probes. In: Methods in cell biology (Goldstein LSB, Fyrberg EA, eds), pp 445-487. San Diego: Academic.
18. Rothberg JM, Hartley DA, Walther Z, Artavanis-Tsakonas S (1988) slit: an EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system. Cell 55:1047-1059.
19. Rothberg JM, Jacobs JR, Goodman CS, Artavanis-Tsakonas S (1990) slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains. Genes Dev 4:2169-2187.
20. Seeger M, Tear G, Ferres-Marco D, Goodman CS (1993) Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron 10:409-426.
21. Stoeckli ET, Sonderegger P, Pollerberg GE, Landmesser LT (1997) Interference with Axonin-1 and NrCAM interactions unmasks a floorplate activity inhibitory for commissural axons. Neuron 18:209-221.
22. Suter DM, Errante LD, Belotserkovsky V, Forscher P (1998) The Ig superfamily cell adhesion molecule, apCAM, mediates growth cone steering by substrate-cytoskeletal coupling. J Cell Biol 141:227-240.
23. Welch MD, Mallavarapu A, Rosenblatt J, Mitchison TJ (1997) Actin dynamics in vivo. Curr Opin Cell Biol 9:54-61.
24. Zallen JA, Yi BA, Bargmann CI (1998) The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans. Cell 92:217-227.