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Volumn 251, Issue 2, 1999, Pages 465-476

Cytokine signal transduction in P19 embryonal carcinoma cells: Regulation of Stat3-mediated transactivation occurs independently of p21ras- Erk signaling

Author keywords

CNTF; ERK; LIF; P19; RAS; STAT

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CALCIUM ION; CILIARY NEUROTROPHIC FACTOR; CYTOKINE; GLYCOPROTEIN GP 130; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P21; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; STAT3 PROTEIN;

EID: 0033568320     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1999.4576     Document Type: Article
Times cited : (12)

References (68)
  • 1
    • 0027048936 scopus 로고
    • Cytokine receptors and signal transduction
    • Taga T., Kishimoto T. Cytokine receptors and signal transduction. FASEB J. 6:1992;3387-3396.
    • (1992) FASEB J. , vol.6 , pp. 3387-3396
    • Taga, T.1    Kishimoto, T.2
  • 2
    • 0029084805 scopus 로고
    • Interleukin-6 family of cytokines and gp130
    • Kishimoto T., Akira S., Narazaki M., Taga T. Interleukin-6 family of cytokines and gp130. Blood. 86:1995;1243-1254.
    • (1995) Blood , vol.86 , pp. 1243-1254
    • Kishimoto, T.1    Akira, S.2    Narazaki, M.3    Taga, T.4
  • 3
    • 0028117163 scopus 로고
    • Cytokine signal transduction
    • Kishimoto T., Taga T., Akira S. Cytokine signal transduction. Cell. 76:1994;253-262.
    • (1994) Cell , vol.76 , pp. 253-262
    • Kishimoto, T.1    Taga, T.2    Akira, S.3
  • 4
    • 0028149838 scopus 로고
    • The tripartite CNTF receptor complex: Activation and signaling involves components shared with other cytokines
    • Stahl N., Yancopoulos G. D. The tripartite CNTF receptor complex: Activation and signaling involves components shared with other cytokines. J. Neurobiol. 25:1994;1454-1466.
    • (1994) J. Neurobiol. , vol.25 , pp. 1454-1466
    • Stahl, N.1    Yancopoulos, G.D.2
  • 10
    • 0029069145 scopus 로고
    • Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
    • Schindler C., Darnell J. E. Jr. Transcriptional responses to polypeptide ligands: The JAK-STAT pathway. Annu. Rev. Biochem. 64:1995;621-651.
    • (1995) Annu. Rev. Biochem. , vol.64 , pp. 621-651
    • Schindler, C.1    Darnell J.E., Jr.2
  • 13
    • 0028931604 scopus 로고
    • Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
    • Stahl N., Farruggella J., Boulton T. G., Zhong Z., Darnell J. E. Jr., Yancopoulos G. D. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science. 267:1995;1349-1353.
    • (1995) Science , vol.267 , pp. 1349-1353
    • Stahl, N.1    Farruggella, J.2    Boulton, T.G.3    Zhong, Z.4    Darnell J.E., Jr.5    Yancopoulos, G.D.6
  • 14
    • 0028845212 scopus 로고
    • Cytokine receptor signaling
    • Ihle J. N. Cytokine receptor signaling. Nature. 377:1995;591-594.
    • (1995) Nature , vol.377 , pp. 591-594
    • Ihle, J.N.1
  • 15
    • 0030046753 scopus 로고    scopus 로고
    • STATs: Signal transducers and activators of transcription
    • Ihle J. N. STATs: Signal transducers and activators of transcription. Cell. 84:1996;331-334.
    • (1996) Cell , vol.84 , pp. 331-334
    • Ihle, J.N.1
  • 16
    • 0028921573 scopus 로고
    • Jaks and Stats in signaling by the cytokine receptor superfamily
    • Ihle J. N., Kerr I. M. Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet. 11:1995;69-74.
    • (1995) Trends Genet. , vol.11 , pp. 69-74
    • Ihle, J.N.1    Kerr, I.M.2
  • 17
    • 0029091195 scopus 로고
    • Stat3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase
    • Boulton T. G., Zhong Z., Wen Z., Darnell J. E., Stahl N., Yancopoulos G. D. Stat3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase. Proc. Natl. Acad. Sci. USA. 92:1995;6915-6919.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 6915-6919
    • Boulton, T.G.1    Zhong, Z.2    Wen, Z.3    Darnell, J.E.4    Stahl, N.5    Yancopoulos, G.D.6
  • 18
    • 0028938929 scopus 로고
    • Interleukin-6-induced serine phosphorylation of transcription factor APRF: Evidence for a role in interleukin-6 target gene induction
    • Lütticken C., Coffer P., Yuan J., Schwartz C., Caldenhoven E., Schindler C., Kruijer W., Heinrich P. C., Horn F. Interleukin-6-induced serine phosphorylation of transcription factor APRF: Evidence for a role in interleukin-6 target gene induction. FEBS Lett. 360:1995;137-143.
    • (1995) FEBS Lett. , vol.360 , pp. 137-143
    • Lütticken, C.1    Coffer, P.2    Yuan, J.3    Schwartz, C.4    Caldenhoven, E.5    Schindler, C.6    Kruijer, W.7    Heinrich, P.C.8    Horn, F.9
  • 19
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen Z., Zhong Z., Darnell J. E. Jr. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell. 82:1995;241-250.
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell J.E., Jr.3
  • 20
    • 0028942656 scopus 로고
    • Requirement of serine phosphorylation for formation of STAT-promoter complexes
    • Zhang X., Blenis J., Li H.-C., Schindler C., Chen-Kiang S. Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science. 267:1995;1990-1994.
    • (1995) Science , vol.267 , pp. 1990-1994
    • Zhang, X.1    Blenis, J.2    Li, H.-C.3    Schindler, C.4    Chen-Kiang, S.5
  • 21
    • 0030088077 scopus 로고    scopus 로고
    • STATs and MAPKs: Obligate or opportunistic partners in signaling
    • Ihle J. N. STATs and MAPKs: Obligate or opportunistic partners in signaling. BioEssays. 18:1996;95-98.
    • (1996) BioEssays , vol.18 , pp. 95-98
    • Ihle, J.N.1
  • 22
    • 0019307417 scopus 로고
    • Teratocarcinomas and mammalian embryogenesis
    • Martin G. R. Teratocarcinomas and mammalian embryogenesis. Science. 209:1980;768-775.
    • (1980) Science , vol.209 , pp. 768-775
    • Martin, G.R.1
  • 23
    • 0020045043 scopus 로고
    • Isolation of male embryonal carcinoma cells and their chromosome replication patterns
    • McBurney M. W., Rogers B. J. Isolation of male embryonal carcinoma cells and their chromosome replication patterns. Dev. Biol. 89:1982;503-508.
    • (1982) Dev. Biol. , vol.89 , pp. 503-508
    • McBurney, M.W.1    Rogers, B.J.2
  • 24
    • 0027153542 scopus 로고
    • P19 embryonal carcinoma cells
    • McBurney M. W. P19 embryonal carcinoma cells. Int. J. Dev. Biol. 37:1993;135-140.
    • (1993) Int. J. Dev. Biol. , vol.37 , pp. 135-140
    • McBurney, M.W.1
  • 25
    • 0028430195 scopus 로고
    • From embryonal carcinoma cells to neurons: The P19 pathway
    • Bain G., Ray W. J., Yao M., Gotlieb D. I. From embryonal carcinoma cells to neurons: The P19 pathway. Bioassays. 16:1994;343-348.
    • (1994) Bioassays , vol.16 , pp. 343-348
    • Bain, G.1    Ray, W.J.2    Yao, M.3    Gotlieb, D.I.4
  • 27
    • 0023649835 scopus 로고
    • CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements
    • Luckow B., Schutz G. CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res. 15:1987;5490.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 5490
    • Luckow, B.1    Schutz, G.2
  • 28
    • 0023793663 scopus 로고
    • Type 1 plasminogen activator inhibitor gene: Functional analysis and glucocorticoid regulation of its promoter
    • van Zonneveld A. J., Curriden A. J., Loskutoff D. J. Type 1 plasminogen activator inhibitor gene: Functional analysis and glucocorticoid regulation of its promoter. Proc. Natl. Acad. Sci. USA. 85:1988;5525-5529.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 5525-5529
    • Van Zonneveld, A.J.1    Curriden, A.J.2    Loskutoff, D.J.3
  • 29
    • 0028910193 scopus 로고
    • Transcriptional regulation of the junB promoter: Analysis of STAT-mediated signal transduction
    • Coffer P., Lutticken C., van Puijenbroek A., Klop-de Jonge M., Horn F., Kruijer W. Transcriptional regulation of the junB promoter: Analysis of STAT-mediated signal transduction. Oncogene. 10:1995;985-994.
    • (1995) Oncogene , vol.10 , pp. 985-994
    • Coffer, P.1    Lutticken, C.2    Van Puijenbroek, A.3    Klop-De Jonge, M.4    Horn, F.5    Kruijer, W.6
  • 30
    • 0027461350 scopus 로고
    • Dominant negative retinoic acid receptor beta
    • Shen S., van der Saag P. T., Kruijer W. Dominant negative retinoic acid receptor beta. Mech. Dev. 40:1993;177-189.
    • (1993) Mech. Dev. , vol.40 , pp. 177-189
    • Shen, S.1    Van Der Saag, P.T.2    Kruijer, W.3
  • 31
    • 0028146329 scopus 로고
    • Stimulation of the human intercellular adhesion molecule-1 promoter by interleukin-6 and interferon-gamma involves binding of distinct factors to a palindromic response element
    • Caldenhoven E., Coffer P., Yuan J., van de Stolpe A., Horn F., Kruijer W., van der Saag P. T. Stimulation of the human intercellular adhesion molecule-1 promoter by interleukin-6 and interferon-gamma involves binding of distinct factors to a palindromic response element. J. Biol. Chem. 269:1994;21146-21154.
    • (1994) J. Biol. Chem. , vol.269 , pp. 21146-21154
    • Caldenhoven, E.1    Coffer, P.2    Yuan, J.3    Van De Stolpe, A.4    Horn, F.5    Kruijer, W.6    Van Der Saag, P.T.7
  • 32
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
    • Burgering B. M. Th., Coffer P. J. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature. 376:1995;599-602.
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.Th.1    Coffer, P.J.2
  • 33
    • 0026127595 scopus 로고
    • Neuronal differentiation in response to epidermal growth factor of transfected murine P19 embryonal carcinoma cells expressing human epidermal growth factor receptors
    • den Hertog J., de Laat S. W., Schlessinger J., Kruijer W. Neuronal differentiation in response to epidermal growth factor of transfected murine P19 embryonal carcinoma cells expressing human epidermal growth factor receptors. Cell Growth Differ. 2:1991;155-164.
    • (1991) Cell Growth Differ. , vol.2 , pp. 155-164
    • Den Hertog, J.1    De Laat, S.W.2    Schlessinger, J.3    Kruijer, W.4
  • 35
    • 0020435972 scopus 로고
    • Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells
    • Gorman C. M., Moffat L. F., Howard B. H. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1982;1044-1051.
    • (1982) Mol. Cell. Biol. , vol.2 , pp. 1044-1051
    • Gorman, C.M.1    Moffat, L.F.2    Howard, B.H.3
  • 37
    • 0024829771 scopus 로고
    • Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines
    • Brasier A. R., Tate J. E., Habener J. F. Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines. BioTechniques. 7:1989;1116-1122.
    • (1989) BioTechniques , vol.7 , pp. 1116-1122
    • Brasier, A.R.1    Tate, J.E.2    Habener, J.F.3
  • 38
    • 0025730640 scopus 로고
    • A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
    • Andrews N. C., Faller D. V. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19:1991;2499.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 2499
    • Andrews, N.C.1    Faller, D.V.2
  • 40
    • 0028913109 scopus 로고
    • A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain
    • Horvath C. M., Wen Z., Darnell J. E. Jr. A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev. 9:1995;984-994.
    • (1995) Genes Dev. , vol.9 , pp. 984-994
    • Horvath, C.M.1    Wen, Z.2    Darnell J.E., Jr.3
  • 41
    • 0027771191 scopus 로고
    • Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus
    • Bonni A., Frank D. A., Schindler C., Greenberg M. E. Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus. Science. 262:1993;1575-1579.
    • (1993) Science , vol.262 , pp. 1575-1579
    • Bonni, A.1    Frank, D.A.2    Schindler, C.3    Greenberg, M.E.4
  • 42
    • 0028605958 scopus 로고
    • STAT proteins participate in the regulation of the vasoactive intestinal peptide gene by the ciliary neurotrophic factor family of cytokines
    • Symes A., Lewis S., Corpus L., Rajan P., Hyman S. E., Fink J. S. STAT proteins participate in the regulation of the vasoactive intestinal peptide gene by the ciliary neurotrophic factor family of cytokines. Mol. Endocrinol. 8:1994;1750-1763.
    • (1994) Mol. Endocrinol. , vol.8 , pp. 1750-1763
    • Symes, A.1    Lewis, S.2    Corpus, L.3    Rajan, P.4    Hyman, S.E.5    Fink, J.S.6
  • 43
    • 0027992051 scopus 로고
    • 12-O-Tetradecanoylphorbol-13-acetate- And tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone: Functional analysis of the intercellular adhesion molecule-1 promoter
    • van de Stolpe A., Caldenhoven E., Stade B. G., Koenderman L., Raaijmakers J. A. M., Johnson J. P., van der Saag P. T. 12-O-Tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone: Functional analysis of the intercellular adhesion molecule-1 promoter. J. Biol. Chem. 269:1994;6185-6192.
    • (1994) J. Biol. Chem. , vol.269 , pp. 6185-6192
    • Van De Stolpe, A.1    Caldenhoven, E.2    Stade, B.G.3    Koenderman, L.4    Raaijmakers, J.A.M.5    Johnson, J.P.6    Van Der Saag, P.T.7
  • 44
    • 0025776411 scopus 로고
    • Leukemia inhibitory factor and interleukin-6 trigger the same immediate early response, including tyrosine phosphorylation, upon induction of myeloid leukemia differentiation
    • Lord K. A., Abdollahi A., Thomas S. M., DeMarco M., Brugge J. S., Hoffman-Liebermann B., Liebermann D. A. Leukemia inhibitory factor and interleukin-6 trigger the same immediate early response, including tyrosine phosphorylation, upon induction of myeloid leukemia differentiation. Mol. Cell. Biol. 11:1991;4371-4379.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 4371-4379
    • Lord, K.A.1    Abdollahi, A.2    Thomas, S.M.3    Demarco, M.4    Brugge, J.S.5    Hoffman-Liebermann, B.6    Liebermann, D.A.7
  • 45
    • 0026092576 scopus 로고
    • Interleukin-6 signals activating junB and TIS11 gene transcription in a B-cell hybridoma
    • Nakajima K., Wall R. Interleukin-6 signals activating junB and TIS11 gene transcription in a B-cell hybridoma. Mol. Cell. Biol. 11:1991;1409-1418.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 1409-1418
    • Nakajima, K.1    Wall, R.2
  • 46
    • 0029133702 scopus 로고
    • Requirement for MAP kinase (ERK2) activity in interferon alpha- And interferon beta-stimulated gene expression through STAT proteins
    • David M., Petricoin E. III, Benjamin C., Pine R., Weber M. J., Larner A. C. Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins. Science. 269:1995;1721-1723.
    • (1995) Science , vol.269 , pp. 1721-1723
    • David, M.1    Petricoin E. III2    Benjamin, C.3    Pine, R.4    Weber, M.J.5    Larner, A.C.6
  • 47
    • 0028884033 scopus 로고
    • PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
    • Allessi D. R., Cuenda A., Cohen P., Dudley D. T., Saltiel A. R. PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270:1995;27489-27494.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27489-27494
    • Allessi, D.R.1    Cuenda, A.2    Cohen, P.3    Dudley, D.T.4    Saltiel, A.R.5
  • 50
    • 0029128120 scopus 로고
    • The LIF response element of the alpha 2 macroplobulin gene confers LIF-induced transcriptional activation in embryonal stem cells
    • Hocke G. M., Cui M-Z., Fey G. H. The LIF response element of the alpha 2 macroplobulin gene confers LIF-induced transcriptional activation in embryonal stem cells. Cytokine. 7:1995;491-502.
    • (1995) Cytokine , vol.7 , pp. 491-502
    • Hocke, G.M.1    Cui, M.-Z.2    Fey, G.H.3
  • 51
    • 0032966863 scopus 로고    scopus 로고
    • Negative regulation of the JAK/STAT pathway
    • Starr R., Hilton D. J. Negative regulation of the JAK/STAT pathway. BioEssays. 21:1999;47-52.
    • (1999) BioEssays , vol.21 , pp. 47-52
    • Starr, R.1    Hilton, D.J.2
  • 52
    • 0031758256 scopus 로고    scopus 로고
    • The CIS/JAB family: Novel negative regulators of JAK signaling pathways
    • Yoshimura A. The CIS/JAB family: Novel negative regulators of JAK signaling pathways. Leukemia. 12:1998;1851-1857.
    • (1998) Leukemia , vol.12 , pp. 1851-1857
    • Yoshimura, A.1
  • 54
    • 0030725378 scopus 로고    scopus 로고
    • Specific inhibition of Stat3 signal transduction by PIAS3
    • Chung C. D., Liao L., Liu B., Rao X., Jay P., Berta P., Shuai K. Specific inhibition of Stat3 signal transduction by PIAS3. Science. 278:1997;1803-1805.
    • (1997) Science , vol.278 , pp. 1803-1805
    • Chung, C.D.1    Liao, L.2    Liu, B.3    Rao, X.4    Jay, P.5    Berta, P.6    Shuai, K.7
  • 55
    • 0028305730 scopus 로고
    • Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor
    • Dittrich E., Rose-John S., Gerhartz C., Müllberg J., Stoyan T., Yasukawa K., Heinrich P. C., Graeve L. Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor. J. Biol. Chem. 269:1994;19014-19020.
    • (1994) J. Biol. Chem. , vol.269 , pp. 19014-19020
    • Dittrich, E.1    Rose-John, S.2    Gerhartz, C.3    Müllberg, J.4    Stoyan, T.5    Yasukawa, K.6    Heinrich, P.C.7    Graeve, L.8
  • 56
    • 0027980394 scopus 로고
    • Phosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytes
    • Wang Y., Fuller G. M. Phosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytes. Mol. Biol. Cell. 5:1994;819-828.
    • (1994) Mol. Biol. Cell. , vol.5 , pp. 819-828
    • Wang, Y.1    Fuller, G.M.2
  • 57
    • 0028279791 scopus 로고
    • Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors
    • Boulton T. G., Stahl N., Yancopoulos G. D. Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J. Biol. Chem. 269:1994;11648-11655.
    • (1994) J. Biol. Chem. , vol.269 , pp. 11648-11655
    • Boulton, T.G.1    Stahl, N.2    Yancopoulos, G.D.3
  • 58
    • 0028859279 scopus 로고
    • Protein modules and signaling networks
    • Pawson T. Protein modules and signaling networks. Nature. 373:1995;573-580.
    • (1995) Nature , vol.373 , pp. 573-580
    • Pawson, T.1
  • 59
    • 0028897113 scopus 로고
    • Transcriptional regulation by extracellular signals: Mechanisms and specificity
    • Hill C. S., Treisman R. Transcriptional regulation by extracellular signals: Mechanisms and specificity. Cell. 80:1995;199-211.
    • (1995) Cell , vol.80 , pp. 199-211
    • Hill, C.S.1    Treisman, R.2
  • 60
    • 0027499295 scopus 로고
    • Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL-6
    • Nakajima T., Kinoshita S., Sasagawa T., Sasaki K., Naruto M., Kishimoto T., Akira S. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL-6. Proc. Natl. Acad. Sci. USA. 90:1993;2207-2211.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2207-2211
    • Nakajima, T.1    Kinoshita, S.2    Sasagawa, T.3    Sasaki, K.4    Naruto, M.5    Kishimoto, T.6    Akira, S.7
  • 61
    • 0027371337 scopus 로고
    • Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation
    • Silvennoinen O., Schindler C., Schlessinger J., Levy D. E. Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation. Science. 261:1993;1736-1739.
    • (1993) Science , vol.261 , pp. 1736-1739
    • Silvennoinen, O.1    Schindler, C.2    Schlessinger, J.3    Levy, D.E.4
  • 62
    • 0027434082 scopus 로고
    • Complementation of a mutant cell line: Central role of the p91kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways
    • Muller M., Laxton C., Briscoe J., Schindler C., Improta T., Darnell J. E., Stark G. R., Kerr I. M. Complementation of a mutant cell line: Central role of the p91kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways. EMBO J. 12:1993;4221-4228.
    • (1993) EMBO J. , vol.12 , pp. 4221-4228
    • Muller, M.1    Laxton, C.2    Briscoe, J.3    Schindler, C.4    Improta, T.5    Darnell, J.E.6    Stark, G.R.7    Kerr, I.M.8
  • 63
    • 0030772458 scopus 로고    scopus 로고
    • Stat3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosinephosphorylation
    • Chung J., Uchida E., Grammer T. C., Blenis J. Stat3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosinephosphorylation. Mol. Cell. Biol. 17:1997;6508-6516.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6508-6516
    • Chung, J.1    Uchida, E.2    Grammer, T.C.3    Blenis, J.4
  • 65
    • 0029936611 scopus 로고    scopus 로고
    • Interleukin-2 activation of Stat5 requires the convergent activation of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway
    • Beadling C., Ng J., Babbage J. W., Cantrell D. A. Interleukin-2 activation of Stat5 requires the convergent activation of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway. EMBO J. 15:1996;1902-1913.
    • (1996) EMBO J. , vol.15 , pp. 1902-1913
    • Beadling, C.1    Ng, J.2    Babbage, J.W.3    Cantrell, D.A.4
  • 66
    • 0030875862 scopus 로고    scopus 로고
    • Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires an activated Jak2 kinase
    • Zhu X., Wen Z., Xu L. Z., Darnell J. E. Jr. Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires an activated Jak2 kinase. Mol. Cell. Biol. 17:1997;6618-6623.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6618-6623
    • Zhu, X.1    Wen, Z.2    Xu, L.Z.3    Darnell J.E., Jr.4
  • 67
    • 0032542211 scopus 로고    scopus 로고
    • Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)
    • Jain N., Zhang T., Fong S. L., Lim C. P., Cao X. Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK). Oncogene. 17:1998;3157-3167.
    • (1998) Oncogene , vol.17 , pp. 3157-3167
    • Jain, N.1    Zhang, T.2    Fong, S.L.3    Lim, C.P.4    Cao, X.5


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