Post-apneic inhalation reverses apnea-induced sympathoexcitation before restoration of blood oxygen levels

Sleep

Volumn 22, Issue 4, 1999, Pages 435-440

  Watenpaugh, Donald E ^a   Muenter, Nicolette K ^a   Wasmund, Wendy L ^a   Wasmund, Stephen L ^a   Smith, Michael L ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Arterial baroreflex; Arterial blood pressure; Autonomic nervous system; Human; Lung inflation; Sleep apnea; Sleep disordered breathing

Indexed keywords

ADRENERGIC ACTIVITY; ADRENERGIC STIMULATION; ADULT; ARTERIAL OXYGEN SATURATION; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BLOOD OXYGENATION; BREATHING DISORDER; FEMALE; HEART RATE; HUMAN; HUMAN EXPERIMENT; LUNG INFLATION; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; OXYGEN BLOOD LEVEL; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; SLEEP APNEA SYNDROME;

NON-PROGRAMMATIC;

ADULT; BLOOD PRESSURE; CHEMORECEPTORS; FEMALE; HUMANS; MALE; MIDDLE AGED; NEURONS, AFFERENT; OXIMETRY; OXYGEN; OXYGEN CONSUMPTION; PSYCHOMOTOR AGITATION; RESPIRATION; SLEEP APNEA SYNDROMES; SYMPATHETIC NERVOUS SYSTEM; TIME FACTORS;

EID: 0033564398     PISSN: 01618105     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Weiss JW, Remsburg S, Garpestad E, Ringler J, Sparrow D, Parker JA. Hemodynamic consequences of obstructive sleep apnea. Sleep 1996;19(5):388-97.
2. Hedner J, Ejnell H, Sellgren J, Hedner T, Wallin G Is high and fluctuating muscle nerve sympathetic activity in the sleep apnoea syndrome of pathogenetic importance for the development of hypertension? J Hypertens 1988;6(suppl 4):S529-31.
3. Morgan BJ. Acute and chronic cardiovascular responses to sleep disordered breathing. Sleep 1996;19(10):S206-9.
4. Smith ML, Niedermaier ON, Hardy SM, Decker MJ, Strohl KP. Role of hypoxemia in sleep apnea-induced sympathoexcitation. J Auton Nerv Syst 1996;56:184-90.
5. Seals DR, Suwarno NO, Dempsey JA. Influence of lung volume on sympathetic nerve discharge in normal humans. Circ Res 1990 July;67(1):130-41.
6. Feldman JL, Ellenberger HH. Central coordination of respiratory and cardiovascular control in mammals. Ann Rev Physiol 1988;50:593-606.
7. Eckberg D, Nerhed C, Wallin B. Respiratory modulation of muscle sympathetic and vagal cardiac outflow in man. J Physiol (Lond) 1985;365:181-96.
8. Delius W, Hagbarth K, Hongell A, Wallin B. Manoeuvres affecting sympathetic outflow in human muscle nerves. Acta Physiol Scand 1972;84:82-94.
9. Series F, Cormier Y, Forge JL. Influence of apnea type and sleep stage on nocturnal postapneic desaturation. Am Rev Respir Dis 1990;141:1522-6.
10. Shepard JW. Cardiorespiratory changes in obstructive sleep apnea. In: Kryger MH, Roth T, Dement WC, editors. Principles and Practice of Sleep Medicine. 2nd ed. Philadelphia: W.B. Saunders Co.; 1994. p 657-66.
11. Fagius J, Wallin B. Sympathetic reflex latencies and conduction velocities in normal man. J Neurol Sci 1980;47:433-48.
12. Fagius J, Sundlof G. The diving response in man: effects on sympathetic activity in muscle and skin nerve fascicles. J Physiol 1986;377:429-43.
13. Hedner JA, Wilcox I, Laks L, Grunstein RR, Sullivan CE. A specific and potent pressor effect of hypoxia in patients with sleep apnea. Am Rev Respir Dis 1992;146:1240-45.
14. Somers VK, Mark AL, Zavala DC, Abboud FM. Influence of ventilation and hypocapnia on sympathetic nerve responses to hypoxia in normal humans. J Appl Physiol 1989;67(5):2095-100.
15. Somers VK, Mark AL, Zavala DC, Abboud FM. Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans. J Appl Physiol 1989;67(5):2101-6.
16. Smith M, Hardy S, Dibner-Dunlap M. Interactive effects of hypoxia and hypercapnia on sympathetic nerve activity in humans. FASEB J 1996;3:A567.
17. Watenpaugh DE, Muenter NK, Wasmund SL, Wasmund WL, Smith ML. Periodic inspiratory efforts during apnea attenuate apnea-induced sympathoexcitation. Circulation 1998;98(Supp. I): 1-472(2481).
18. Shimizu T, Takahashi Y, Kogawa S, Takahashi K-I, Saito Y, Hishikawa Y, Broughton RJ. Muscle sympathetic nerve activity during central, mixed and obstructive apnea: are there any differences? Psych Clin Neurosci 1997;51:397-403.
19. Saul JP, Rea RF, Eckberg DL, Berger RD, Cohen RJ. Heart rate and muscle sympathetic nerve variability during reflex changes of autonomic activity. Am J Physiol 1990;258(Heart Circ Physiol 27):H713-21.
20. Somers VK, Mark AL, Abboud FM. Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans. J Clin Invest 1991;87:1953-7.
21. Ashton J, Cassidy S. Reflex depression of cardiovascular function during lung inflation. J Appl Physiol 1985;58:137-45.
22. Bronk D, Ferguson L, Margaria R, Solandt D. The activity of the cardiac sympathetic centers. Am J Physiol 1936;117:237-49.
23. Gerber U, Polosa C. Effects of pulmonary stretch receptor afferent stimulation on sympathetic preganglionic neuron firing. Can J Physiol Pharmacol 1978;56:191-8.
24. Gootman P, Feldman J, Cohen M. Pulmonary afferent influences on respiratory modulation of sympathetic discharge. In: Koepchen H, Hilton S, Trzebski A, eds. Central interaction between respiratory and cardiovascular control systems. Berlin: Springer-Verlag, 1980:172-8.
25. Daly M, Hazzledine J, Ungar A. The reflex effects of alterations in lung volume on systemic vascular resistance in the dog. J Physiol (Lond) 1967;188:331-51.
26. Bainton C, Richter D, Seller H, Ballantyne D, Klein J. Respiratory modulation of sympathetic activity. J Auton Nerv Syst 1985;12:77-90.
27. Haselton J, Guyenet P. Central respiratory modulation of medullary sympathoexcitatory neurons in rat. Am J Physiol 1989;25:R739-50.
28. McAllen R. Central respiratory modulation of subretrofacial bulbospinal neurones in the cat. J Physiol 1987;388:533-45.
29. Wallin BG, Nerhed C. Relationship between spontaneous variations of muscle sympathetic activity and succeeding changes of blood pressure in man. J Auton Nerv Syst 1982;6:293-302.
30. O'Donnell CP, Schwartz AR, Smith PL, Robotham JL, Fitzgerald RS, Shirahata M. Reflex stimulation of renal sympathetic nerve activity and blood pressure in response to apnea. Am J Respir Crit Care Med 1996;154:1763-70.
31. Garpestad E, Katayama H, Parker JA, et al. Stroke volume and cardiac output decrease at termination of obstructive apneas. J Appl Physiol 1992;73(5):1743-8.
32. Goodnight White S, Fletcher EC, Miller III CC. Acute systemic blood pressure elevation in obstructive and nonobstructive breath hold in primates. J Appl Physiol 1995;79(1):324-30.
33. Ringler J, Basner R, Shannon R, et al. Hypoxemia alone does not explain blood pressure elevations after obstructive apneas. J Appl Physiol 1990;69:2143-8.
34. O'Donnell C, King E, Schwartz A, Robotham J, Smith P. Relationship between blood pressure and airway obstruction during sleep in the dog. J Appl Physiol 1994;77:1819-28.
35. O'Donnell C, Ayuse T, King E, Schwartz A, Smith P, Robotham J. Airway obstruction during sleep increases blood pressure without arousal. J Appl Physiol 1996;80(3):773-81.
36. Zinkovska S, Kirby DA. Intracerebroventricular propranolol prevented vascular resistance increases on arousal from sleep apnea. J Appl Physiol 1997;82(5):1637-43.