Differential presentation of an altered peptide within fetal central and peripheral organs supports an avidity model for thymic T cell development and implies a peripheral readjustment for activation

Journal of Immunology

Volumn 162, Issue 10, 1999, Pages 5738-5746

  Legge, Kevin L ^a   Min, Booki ^a   Pack, Christopher ^a   Caprio, Jacque ^a   Zaghouani, Habib ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; PROTEOLIPID PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ARTICLE; CELL MATURATION; CELL SELECTION; FETUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

ANIMALS; ANTIGEN PRESENTATION; CLONE CELLS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNE SYSTEM; IMMUNE TOLERANCE; LYMPH NODES; LYMPHOCYTE ACTIVATION; MATERNAL-FETAL EXCHANGE; MICE; MICE, INBRED STRAINS; MODELS, IMMUNOLOGICAL; PEPTIDE FRAGMENTS; PREGNANCY; PROTEOLIPIDS; RECOMBINANT FUSION PROTEINS; SPLEEN; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0033563160     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Lo, D., and J. Sprent. 1986. Identity of cells that imprint H-2-restricted T-cell specificity in the thymus. Nature 319:672.
2. Kisielow, P., H. S. Teh, H. Bluthmann, and H. von Boehmer. 1988. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature 335:730.
3. Bevan, M. J. 1977. In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature 269:417.
4. Zinkernagel, R. M., G. N. Callahan, A. Althage, S. Cooper, P. A. Klein, and J. Klein. 1978. On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition? J. Exp. Med. 147:882.
5. Jameson, S. C., K. A. Hogquist, and M. J. Bevan. 1995. Positive selection of thymocytes. Annu. Rev. Immunol. 13:93.
6. Schwartz, R. H. 1989. Acquisition of immunologic self-tolerance. Cell 57:1073.
7. Hugo, P., J. W. Kappler, and P. C. Marrack. 1993. Positive selection of TCR αβ thymocytes: is cortical thymic epithelium an obligatory participant in the presentation of major histocompatibility complex protein? Immunol. Rev. 135:133.
8. Ashton-Rickardt, P. G., A. Bandeira, J. R. Delaney, L. Van Kaer, H. P. Pircher, R. M. Zinkernagel, and S. Tonegawa. 1994. Evidence for a differential avidity model of T cell selection in the thymus. Cell 76:651.
9. Ashton-Rickardt, P. G., and S. Tonegawa. 1994. A differential-avidity model for T-cell selection. Immunol. Today 15:362.
10. Hsu, B. L., B. D. Evavold, and P. M. Allen. 1995. Modulation of T cell development by an endogenous altered peptide ligand. J. Exp. Med. 181:805.
11. Sebzda, E., V. A. Wallace, J. Mayer, R. S. Yeung, T. W. Mak, and P. S. Ohashi. 1994. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 263:1615.
12. Janeway, C. A., Jr., A. Rudensky, S. Rath, and D. Murphy. 1992. Immune development: it is easier for a camel to pass the needle's eye. Curr. Biol. 2:26.
13. Kersh, G. J., and P. M. Allen. 1996. Essential flexibility in the T cell recognition of antigen. Nature 380:495.
14. Adkins, B., C. Mueller, C. Y. Okada, R. A. Reichert, I. L. Weissmann, and G. J. Spangrude. 1987. Early events in T-cell maturation. Annu. Rev. Immunol. 5:325.
15. Janeway, C. A., Jr., U. Dianzani, P. Portoles, S. Rath, E. P. Reich, J. Rojo, J. Yagi, and D. B. Murphy. 1989. Cross-linking and conformational change in T-cell receptors: role in activation and in repertoire selection. Cold Spring Harbor Symp. Quant. Biol. 54:657.
16. Mannie, M. D. 1991. A unified model for T cell antigen reconition and thymic selection of the T cell receptor. J. Theor. Biol. 151:169.
17. Hogquist, K. A., S. C. Jameson, W. R. Heath, J. L. Howard, M. J. Bevan, and F. R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76:17.
18. Jameson, S. C., K. A. Hogquist, and M. J. Bevan. 1994. Specificity and flexibility in thymic selection. Nature 369:750.
19. + thymocytes by T-cell receptor peptide antagonist. Proc. Natl Acad. Sci. USA 91:4057.
20. Spain, L. M., J. L. Jorgensen, M. M. Davis, and L. J. Berg. 1994. A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes. J. Immunol. 152:1709.
21. Marrack, P., L. Ignatowicz, J. W. Kappler, J. Boymel, and J. H. Freed. 1993. Comparison of peptides bound to spleen and thymus class II. J. Exp. Med. 178: 2173.
22. Vidal, K., and P. M. Allen. 1996. The effect of endogenous altered peptide ligand on peripheral T-cell response. Immunology 8:117.
23. Tuohy, V. K., Z. Lu, R. A. Sobel, R. A. Laursen, and M. B. Lees. 1989. Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J. Immunol. 142:1523.
24. McRae, B. L., M. K. Kennedy, L. J. Tan, M. C. Dal Canto, K. S. Picha, and S. D. Miller. 1992. Induction of active and adoptive relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein. J. Neuroimmunol. 38:229.
25. Sobel, R. A., and V. K. Kuchroo. 1992. The immunopathology of acute experimental allergic encephalomyelitis induced with myelin proteolipid protein. T cell receptors in inflammatory lesions. J. Immunol. 149:1444.
26. Kuchroo, V. K., J. M. Greer, D. Kaul, G. Ishioka, A. Franco, A. Sette, R. A. Sobel, and M. B. Lees. 1994. A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire. J. Immunol. 153:3326.
27. Legge, K. L., B. Min, N. T. Potter, and H. Zaghouani. 1997. Presentation of a T cell receptor antagonist peptide by immunoglobulins ablates activation of T cells by a synthetic peptide or proteins requiring endocytic processing. J. Exp. Med. 185:1043.
28. Legge, K. L. B. Min, A. E. Cestra, C. D. Pack, and H. Zaghouani. 1998. TCR agonist and antagonist exert in vivo cross-regulation when presented on Igs. J. Immunol. 161:106.
29. Lyons, D. S., S. A. Lieberman, J. Hampl, J. J. Boniface, Y. Chien, L. J. Berg, and M. M. Davis. 1996. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 5:53.
30. Greer, J. M., V. K. Kuchroo, R. A. Sobel, and M. B. Lees. 1992. Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice. J. Immunol. 149:783.
31. Forsthuber, T., H. C. Tip, and P. Lehmann. 1996. Induction of Th1 and Th2 immunity in neonatal mice. Science 271:1728.
32. Jenkinson, E. J., W. Van Ewijk, and J. J. Owen. 1981. Major histocompatibility complex antigen expression on the epithelium of the developing thymus in normal and nude mice. J. Exp. Med. 153:280.
33. Van Vilet, E., E. J. Jenkinson, R. Kingston, J. J. Owen, and W. Van Ewijk. 1985. Stromal cell types in the developing thymus of the normal and nude mouse embryo. Eur. J. Immunol. 15:675.
34. Roehm, N., L. Herron, J. Cambier, D. DiGuisto, K. Haskins, J. Kappler, and P. Marrack. 1984. The major histocompatibility complex-restricted antigen receptor on T cells: distribution on thymus and peripheral T cells. Cell 38:577.
35. Snodgrass, H. R., P. Kisielow, M. Kiefer, M. Steinmetz, and H. von Boehmer. 1985. Ontogeny of the T-cell antigen receptor within the thymus. Nature 313:592.
36. Born, W., J. Yague, E. Palmer, J. Kappler, and P. Marrack. 1985. Rearrangement of T-cell receptor β-chain genes during T-cell development. Proc. Natl. Acad. Sci. USA 82:2925.
37. Haars, R., M. Kronenberg, W. M. Gallatin, I. L. Weissman, F. L. Owen, and L. Hood. 1986. Rearrangement and expression of T cell antigen receptor and κ genes during thymic development. J. Exp. Med 164:1.
38. k complexes: correlation of the dissociation rate with T-cell responsiveness. Proc. Natl Acad. Sci. USA 91:12862.
39. Valitutti, S., and A. Lanzavecchia. 1997. Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition. Immunol. Today 18:299.
40. Webb, S., C. Moms, and J. Sprent. 1990. Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell 63:1249.
41. Rocha, B., and H. von Boehmer. 1991. Peripheral selection of the T cell repertoire. Science 251:1225.
42. McCormack, J. E., J. E. Callahan, J. Kappler, and P. C. Marrack. 1993. Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen. J. Immunol. 150:3785.
43. Moskophidis, D., F. Lechner, H. Pircher, and R. M. Zinkernagel. 1993. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 362:758.
44. Pircher, H., U. M. Rohrer, D. Moskophidis, R. M. Zinkernagel, and H. Hengartner. 1991. Lower receptor avidity required for thymic clonal deletion than for effector T-cell function. Nature 351:482.
45. Yagi, J., and C. A. Janeway, Jr. 1990. Ligand thresholds at different stages of T cell development. Int. Immunol. 2:83.
46. Vidal, K., B. L. Hsu, C. B. Williams, and P. M. Allen. 1996. Endogenous altered peptide ligands can affect peripheral T cell responses. J. Exp. Med. 183:1311.
47. Wack, A., H. M. Ladyman, O. Williams, K. Roderick, M. A. Ritter, and D. Kioussis 1996. Direct visualization of thymocyte apoptosis in neglect, acute and steady state negative selection. Int. Immunol. 8:1537.
48. Harrington, C. J., A. Paez, T. Hunkapiller, V. Mannikko, T. Brabb, M. Ahearn, C. Beeson, and J. Goverman. 1998. Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein. Immunity 8:571.