Selective degeneration of purkinje cells with lewy body-like inclusions in aged NFHLACZ transgenic mice

Journal of Neuroscience

Volumn 17, Issue 3, 1997, Pages 1064-1074

  Tu, Pang Hsien ^a   Robinson, Kathryn A ^a   De Snoo, Femke ^a   Eyer, Joel ^b   Peterson, Alan ^c   Lee, Virginia M Y ^a   Trojanowski, John Q ^a,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Institut National de la Santé   (France)

^c ROYAL VICTORIA HOSPITAL   (Canada)

^d HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

apoptosis; Lewy body; necrosis; neurodegeneration; neurofilament; Parkinson's disease; phosphorylation; Purkinje cells

Indexed keywords

BETA GALACTOSIDASE; HYBRID PROTEIN; NEUROFILAMENT PROTEIN; TRYPSIN;

AGED; AGING; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INCLUSION; CELL ORGANELLE; CONTROLLED STUDY; GENE FUSION; HIPPOCAMPUS; LEWY BODY; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEUROFILAMENT; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PURKINJE CELL; TRANSGENIC MOUSE; ANIMAL; BIOSYNTHESIS; CELL DEATH; DRUG EFFECT; METABOLISM; MOUSE; NERVE DEGENERATION; PATHOLOGY; ULTRASTRUCTURE;

AGING; ANIMALS; CELL DEATH; LEWY BODIES; MICE; MICE, TRANSGENIC; NERVE DEGENERATION; NEUROFILAMENT PROTEINS; PURKINJE CELLS; TRYPSIN;

EID: 0030614372     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-03-01064.1997     Document Type: Article

References (31)

1. Archer DR, Watson DF, Griffin JW (1994) Phosphorylation-dependent immunoreactivity of neurofilaments and the rate of slow axonal transport in the central and peripheral axons of the rat dorsal root ganglion. J Neurochem 62:1119-1125.
2. Arnold SE, Lee VMY, Gurney RE, Trojanowski JQ (1991) Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia. Proc Natl Acad Sci USA 88:10850-10854.
3. Bergeron C, Beric-Maskarel K, Muntasser S, Weyer L, Somerville MJ, Percy ME (1994) Neurofilament light and polyadenylated mRNA levels are decreased in amyotrophic lateral sclerosis motor neurons. J Neuropathol Exp Neurol 53:221-230.
4. Bramblett GT, Goedert M, Jakes R, Merrick SE, Trojanowski JQ, Lee VMY (1993) Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 10:1089-1099.
5. Brorson JR, Manzolillo PA, Gibbons SJ, Miller RJ (1995) AMPA receptor desensitization predicts the selective vulnerability of cerebellar Purkinje cells to excitotoxicity. 15:4515-4524.
6. Caddy KWT, Biscoe TJ (1979) Structural and quantitative studies on the normal C3H and lurcher mutant mouse. Philos Trans R Soc Lond [Biol] 287:167-201.
7. Calne DB, Hoehberg FH, Snow BJ, Nygaard T (1992) Theories of neurodegeneration. Ann NY Acad Sci 648:1-5.
8. Carden MJ, Trojanowski JQ, Schlaepfer WW, Lee VMY (1987) Two-stage expression of neurofilament polypeptides during rat neurogenesis with early establishment of adult phosphorylation patterns. J Neurosci 7:3489-3504.
9. Cervos-Navarro J, Diemer NH (1991) Selective vulnerability in brain hypoxia. Crit Rev Neurobiol 6:149-182.
10. Ching GY, Liem RKH (1993) Assembly of type IV neuronal intermediate filaments in nonneuronal cells in the absence of preexisting cytoplasmic intermediate filaments. J Cell Biol 122:1323-1335.
11. Ciechanover A (1994) The ubiquitin-proteasome proteolytic pathway. Cell 79:13-21.
12. Cleeter MWJ, Cooper JM, Schapira AHV (1992) Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: evidence for free radical involvement. J Neurochem 58:786-789.
13. Cole JS, Messing A, Trojanowski JQ, Lee VMY (1994) Modulation of axon diameter and neurofilaments by hypomyelinating Schwann cells in transgenic mice. J Neurosci 14:6956-6966.
14. Collard JF, Côté F, Julien JP (1995) Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis. Nature 375:61-64.
15. Côté F, Collard JF, Julien JP (1993) Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis. Cell 73:35-46.
16. de Waegh S, Lee VMY, Brady ST (1992) Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells. Cell 68:451-463.
17. Eyer J, Peterson A (1994) Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-β-galactosidase fusion protein. Neuron 12:389-405.
18. Feddersen RM, Ehlenfeldt R, Yunis WS, Clark HB, Orr HT (1992) Disrupted cerebellar cortical development and progressive degenera-tion of Purkinje cells in SV40 T antigen transgenic mice. Neuron 9:955-966.
19. Ferrer I, Genist D, Bernado L, Sant F, Serrano (1994) The Purkinje cell in olivopontocerebellar atrophy. A Golgi and immunohistochemical study. Neuropathol Appl Neurobiol 20:38-46.
20. Forno LS (1986) The Lewy body in Parkinson's disease. Adv Neurol 45:35-43.
21. Fujii H, Nakamura K, Takeo K, Kawai S (1993) Heterogeneity of carbonic anhydrase and 68 kDa neurofilament in nerve roots analyzed by two-dimensional electrophoresis. Electrophoresis 14:1074-1078.
22. Gavrieli Y, Sherman Y, Ben-Sasson S, (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501.
23. Gold BG, Austin DR (1991) Regulation of aberrant neurofilament phosphorylation in neuronal perikarya. I. Production following colchicine application to the sciatic nerve. J Neuropathol Exp Neurol 50:615-626.
24. Goldman JE, Yen SH (1987) Cytoskeletal protein abnormalities in neurodegenerative diseases. Ann Neurol 19:209-223.
25. Goldstein ME, Cooper HS, Carden MJ, Lee VMY, Schlaepfer WW (1987) Phosphorylation of neurofilament proteins and chromatolysis following transection of rat sciatic nerve. J Neurosci 7:1586-1594.
26. Goldstein ME, Weiss SR, Lazzarini RA, Shneidman PS, Lees JF, Schlaepfer W W (1988) mRNA levels of all three neurofilament proteins decline following nerve transection. Mol Brain Res 3:287-292.
27. Gurney ME, Pu H, Chiu AY, Canto MCD, Polchow CY, Alexander DD, Caliendo J, Hentati A, Kwon YW, Deng HX, Chen W, Zhai P, Sufit RL, Siddique T (1994) Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation. Science 264:1772-1775.
28. Hill WD, Lee VMY, Hurtig H, Murray JM, Trojanowski JQ (1991) Epitopes located in spatially separate domains of each neurofilament subunit are present in Parkinson's disease Lewy body. J Comp Neurol 309:150-160.
29. Yamada E, Hazama F (1993) Different stability of neurofilaments for trypsin treatment after axotomy in the dorsal motor nucleus of the vagal nerve and the hypoglossal nucleus. Brain Res 612:210-215.
30. Yamasaki H, Bennett GS, Itakura C, Mizutani M (1992) Defective expression of neurofilament protein subunits in hereditary hypotrophic axonopathy of quail. Lab Invest 66:734-743.
31. Zhao JX, Ohnishi A, Itakura C, Mizutani M, Yamamoto T, Hayashi H, Murai Y (1994) Greater number of microtubules per axon of unmyelinated fibers of mutant quails deficient in neurofilaments: possible compensation for the absence of neurofilaments. Acta Neuropathol 87:332-336.