Phosphorylation-mediated control of chromatin organization and transcriptional activity of the tissue-specific osteocalcin gene

Journal of Cellular Biochemistry

Volumn 72, Issue 4, 1999, Pages 586-594

  Montecino, Martin ^b   Van Wijnen, André J ^a   Lian, Jane B ^a   Stein, Janet L ^a   Stein, Gary S ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CONCEPCIÓN   (Chile)

Author keywords

Chromatin structure; Okadaic acid; Osteocalcin gene; Transcriptional regulation

Indexed keywords

COLECALCIFEROL DERIVATIVE; OKADAIC ACID; OSTEOCALCIN; PROTEIN KINASE C INHIBITOR; STAUROSPORINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CHROMATIN CONDENSATION; CONTROLLED STUDY; GENE ISOLATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; RAT; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

ANIMALS; CHROMATIN; DEOXYRIBONUCLEASE I; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; OKADAIC ACID; OSTEOCALCIN; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN KINASE C; RATS; STAUROSPORINE; TUMOR CELLS, CULTURED; VITAMIN D;

EID: 0033559678     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19990315)72:4<586::AID-JCB13>3.0.CO;2-K     Document Type: Article

References (44)

1. Ajiro K, Yoda K, Utsumi K, Nishikawa Y. 1996. Alteration of cell cycle-dependent histone phosphorylations by okadaic acid. Induction of mitosis-specific H3 phosphorylation and chromatin condensation in mammalian interphase cells. J Biol Chem 271:13197-13201.
2. Aronow MA, Gerstenfeld LC, Owen TA, Tassinari MS, Stein GS, Lian JB. 1990. Factors that promote progressive development of the osteoblast phenotype in cultured fetal rat calvaria cells. J Cell Physiol 143:213-221.
3. Banerjee C, Hiebert SW, Stein JL, Lian JB, Stein GS. 1996. An AML-1 consensus sequence binds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene. Proc Natl Acad Sci USA 93:4968-4973.
4. Barlev NA, Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman JL, Berger SL. 1998. Repression of GCN5 histone acetyltransferase activity via bromodomain- mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex. Mol Cell Biol 18:1349-1358.
5. Bidwell JP, van Wijnen AJ, Fey EG, Dworetzky S, Penman S, Stein JL, Lian JB, Stein GS. 1993. Osteocalcin gene promoter-binding factors are tissue-specific nuclear matrix components. Proc Natl Acad Sci USA 90:3162-3166.
6. Bortell R, Owen TA, Bidwell JP, Gavazzo P, Breen E, van Wijnen AJ, DeLuca HF, Stein JL, Lian JB, Stein GS. 1992. Vitamin D-responsive protein-DNA interactions at multiple promoter regulatory elements that contribute to the level of rat osteocalcin gene expression. Proc Natl Acad Sci USA 89:6119-6123.
7. Bradbury EM. 1992. Reversible histone modifications and the chromosome cell cycle. BioEssays 14:9-16.
8. Breen EC, van Wijnen AJ, Lian JB, Stein GS, Stein JL. 1994. In vivo occupancy of the vitamin D responsive element in the osteocalcin gene supports vitamin D-dependent transcriptional upregulation in intact cells. Proc Natl Acad Sci USA 91:12902-12906.
9. Chadee DN, Allis CD, Wright JA, Davie JR. 1997. Histone H1b phosphorylation is dependent upon ongoing transcription and replication in normal and ras-transformed mouse fibroblasts. J Biol Chem 272:8113-8116.
10. Demay MB, Gerardi JM, DeLuca HF, Kronenberg HM. 1990. DNA sequences in the rat osteocalcin gene that bind the 1,25-dihydroxyvitamin D3 receptor and confer responsive to 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci USA 87:369-373.
11. Desai RK, van Wijnen AJ, Stein JL, Stein GS, Lian JB. 1995. Control of 1,25-dihydroxyvitamin D3 receptor-mediated enhancement of osteocalcin gene transcription: Effects of perturbing phosphorylation pathways by okadaic acid and staurosporine. Endocrinology 136:5685-5693.
12. Ducy P, Karsenty G. 1995. Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene. Mol Cell Biol 15:1858-1869.
13. Elgin SC. 1988. The formation and function of DNase I hypersensitive sites in the process of gene activation. J Biol Chem 263:19259-19262.
14. Feng JL, Irving J, Villeponteau B. 1991. A phosphatase inhibitor enhances the DNase I sensitivity of active chromatin. Biochemistry 30:4747-4752.
15. Giffin W, Torrance H, Rodda DJ, Prefontaine GG, Pope L, Hache RJ. 1996. Sequence-specific DNA binding by Ku autoantigen and its effects on transcription. Nature 380: 265-268.
16. Gross DS, Garrard WT. 1988. Nuclease hypersensitive sites in chromatin. Ann Rev Biochem 57:159-197.
17. Gundberg CM, Hauschka PV, Lian JB, Gallop PM. 1984. Osteocalcin: Isolation, characterization, and detection. Methods Enzymol 107:516-544.
18. Guo B, Odgren PR, van Wijnen AJ, Last TJ, Nickerson J, Penman S, Lian JB, Stein JL, Stein GS. 1995. The nuclear matrix protein NMP-1 is the transcription factor YY1. Proc Natl Acad Sci USA 92:10526-10530.
19. Guo XW, Th'ng JP, Swank RA, Anderson HJ, Tudan C, Bradbury EM, Roberge M. 1995. Chromosome condensation induced by fostriecin does not require p34cdc2 kinase activity and histone H1 hyperphosphorylation, but is associated with enhanced histone H2A and H3 phosphorylation. EMBO J 14:976-985.
20. Herrera RE, Chen F, Weinberg RA. 1996. Increased histone H1 phosphorylation and relaxed chromatin structure in Rb-deficient fibroblasts. Proc Natl Acad Sci USA 93: 11510-11515.
21. Hoffmann HM, Catron KM, van Wijnen AJ, McCabe LR, Lian JB, Stein GS, Stein JL. 1994. Transcriptional control of the tissue-specific, developmentally regulated osteocalcin gene requires a binding motif for the Msx family of homeodomain proteins. Proc Natl Acad Sci USA 91:12887-12891.
22. Hoffmann HM, Beumer TL, Rahman S, McCabe LR, Banerjee C, Aslam F, Tiro JA, van Wijnen AJ, Stein JL, Stein GS, Lian JB. 1996. Bone tissue-specific transcription of the osteocalcin gene: Role of an activator osteoblast-specific complex and suppressor hox proteins that bind the OC box. J Cell Biochem 61:310-324.
23. Jurutka PW, Terpening CM, Haussler MR. 1993. The 1,25-dihydroxy-vitamin D3 receptor is phosphorylated in response to 1,25-dihydroxy-vitamin D3 and 22-oxacalcitriol in rat osteoblasts, and by casein kinase II, in vitro. Biochemistry 32:8184-8192.
24. Jurutka PW, Hsieh JC, Nakajima S, Haussler CA, Whitfield GK, Haussler MR. 1996. Human vitamin D receptor phosphorylation by casein kinase II at Ser-208 potentiates transcriptional activation. Proc Natl Acad Sci USA 93:3519-3524.
25. Kuhn A, Gottlieb TM, Jackson SP, Grummt I. 1995. DNA-dependent protein kinase: A potent inhibitor of transcription by RNA polymerase I. Genes Dev 9:193-203.
26. Mahadevan LC, Willis AC, Barratt MJ. 1991. Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors. Cell 65:775-783.
27. Majeska RJ, Rodan SB, Rodan GA. 1980. Parathyroid hormone-responsive clonal cell lines from rat osteosarcoma. Endocrinology 107:1494-1503.
28. Markose ER, Stein JL, Stein GS, Lian JB. 1990. Vitamin D-mediated modifications in protein-DNA interactions at two promoter elements of the osteocalcin gene. Proc Natl Acad Sci USA 87:1701-1705.
29. Meggio F, Donella Deana A, Ruzzene M, Brunati AM, Cesaro L, Guerra B, Meyer T, Mett H, Fabbro D, Furet P. 1995. Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2. Eur J Biochem 234:317-322.
30. Merriman HL, van Wijnen AJ, Hiebert S, Bidwell JP, Fey E, Lian J, Stein J, Stein GS. 1995. The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/ PEBP2/runt domain transcription factor family: Interactions with the osteocalcin gene promoter. Biochemistry 34:13125-13132.
31. Montecino M, Pockwinse S, Lian J, Stein G, Stein J. 1994. DNase I hypersensitive sites in promoter elements associated with basal and vitamin D dependent transcription of the bone-specific osteocalcin gene. Biochemistry 33:348-353.
32. Montecino M, Lian J, Stein G, Stein J. 1996. Changes in chromatin structure support constitutive and develomentally regulated transcription of the bone-specific osteocalcin gene in osteoblastic cells. Biochemistry 35:5093-5102.
33. Montecino M, Frenkel B, van Wijnen A, Lian J, Stein G, Stein J. Chromatin hyperacetylation abrogates vitamin D-mediated transcriptional upregulation of the tissue-specific osteocalcin gene in vivo. Biochemistry, in press.
34. Newberry EP, Boudreaux JM, Towler DA. 1997. Stimulus-selective inhibition of rat osteocalcin promoter induction and protein-DNA interactions by the homeodomain represser Msx2. J Biol Chem 272:29607-29613.
35. Owen TA, Aronow M, Shalhoub V, Barone LM, Wilming L, Tassinari MS, Kennedy MB, Pockwinse S, Lian JB, Stein GS. 1990. Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J Cell Physiol 143:420-430.
36. Strahl K. 1998. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev 12:599-606.
37. Tamura M, Noda M. 1994. Identification of a DNA sequence involved in osteoblast-specific gene expression via interaction with helix-loop-helix (HLH)-type transcription factors. J Cell Biol 126:773-782.
38. Terpening CM, Haussler CA, Jurutka PW, Galligan MA, Komm BS, Haussler MR. 1991. The vitamin D-responsive element in the rat bone G1a protein gene is an imperfect direct repeat that cooperates with other cis-elements in 1,25-dihydroxyvitamin D3-mediated transcriptional activation. Mol Endocrinol 5:373-385.
39. Towler DA, Bennett CD, Rodan GA. 1994a. Activity of the rat osteocalcin basal promoter in osteoblastic cells is dependent upon homeodomain and CP1 binding motifs. Mol Endocrinol 8:614-624.
40. Towler DA, Rutledge SJ, Rodan GA. 1994b. Msx-2/Hox 8.1: A transcriptional regulator of the rat osteocalcin promoter. Mol Endocrinol 8:1484-1493.
41. Wilkinson SE, Parker PJ, Nixon JS. 1993. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J 294:335-337.
42. Wolffe AP, Pruss D. 1996. Targeting chromatin disruption: transcription regulators that acetylate histones. Cell 84: 817-819.
43. Wu C. 1980. The 5' ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I. Nature 286: 854-860.
44. Zlatanova JS, van Holde KE. 1992. Chromatin loops and transcriptional regulation. Crit Rev Eukaryot Gene Exp 2:211-224.