Capsaicin-induced inhibition of mitogen and interleukin-2-stimulated T cell proliferation: Its reversal by in vivo substance P administration

Journal of Neuroimmunology

Volumn 68, Issue 1-2, 1996, Pages 131-138

  Santoni, Giorgio ^a   Perfumi, Marina ^a   Bressan, Anna Maria ^b   Piccoli, Mario ^b  

^a UNIVERSITY OF CAMERINO   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Capsaicin; Lymphocyte subsets; Newborn rats; Substance P; T cell proliferation

Indexed keywords

CAPSAICIN; CD4 ANTIGEN; CD5 ANTIGEN; INTERLEUKIN 2; RECOMBINANT INTERLEUKIN 2; SUBSTANCE P;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; IMMUNOMODULATION; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN CELL; SUBCUTANEOUS DRUG ADMINISTRATION; T LYMPHOCYTE SUBPOPULATION;

EID: 0030219849     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-5728(96)00081-1     Document Type: Article

References (50)

1. Bar-Shavit A., Goldman R., Stabinsky Y., Gottlieb P., Fridkin M., Teichberg V.I., Blumberg S. Enhancement of phagocytosis - A newly found activity of Substance P residing in its N terminal tetrapeptide sequence. Biochem. Biophys. Res. Commun. 94:1980;1445-1451.
2. Bellinger D.L., Lorton D., Romano T., Olschowka J.A., Felten S.Y., Felten D.L. Neuropeptide innervation of lymphoid organs. Ann. NY Acad. Sci. 594:1990;17-33.
3. Blalock J.E., Smith E.M. The immune system: our mobile brain? Immun. Today. 6:1985;115-117.
4. Blalock J.E. The immune system. Our sixth sense. Immunologist. 2(1):1994;8-15.
5. Bullock, K. (1985) Neuroanatomy of lymphoid tissue: a review. In: ed. R. Guillemin, M. Cohen, T. Melnechuck, Neuromodulation of Immunity. Raven, New York, pp. 111-141.
6. Chambers W.H., Vujanovic N.L., DeLeo A.B., Olskowy M.W., Herberman R.B., Hiserodt J.C. Monoclonal antibody to a triggering structure expressed on rat natural killer cells and adherent lymphokine activated killer cells. J. Exp. Med. 169:1989;1373-1389.
7. Eglezos A., Andrews P.V., Boyd R.L., Helme R.D. Effect of capsaicin treatment on immunoglobulin secretion in the rat: further evidence for involvement of tachykinin-containing afferent nerves. J. Neuroimmunol. 26:1990;131-138.
8. Eglezos A., Andrew P.V., Boyd R.L., Helme R.D. Modulation of the immune response by tachykinins. Immunol. Cell Biol. 69:1991;285-294.
9. Felten D.L., Felten S.Y., Carlson S.L., Olschowka J.A., Livnat S. Noradrenergic and peptidergic innervation of lymphoid tissue. J. Immunol. 135:1985;755-798.
10. Felten D.L., Felten S.Y., Bellinger D.L., Lorton D. Noradrenergic and peptinergic innervation of secondary lymphoid organs: role in experimental rheumatoid arthritis. Eur. J. Clin. Invest. 2:1992;37-41.
11. Felten, D.L. and Felten S.Y. (1989) Innervation of the thymus. In: ed. M.D. Kendall and M.A. Ritter, Thymus Update. Harwood Acad. Publ., London, pp. 78-88.
12. Gamse R., Leeman S.E., Holzer P., Lembeck F. Differential effects of somatostatin, Substance P and neurotensin in the nervous system of the rat. Naunyn-Schmiedeberg's Arch. Pharmacol. 317:1981;140-148.
13. Geppetti P., Maggi C.A., Orlandini S., Santicioli P., Meli A., Frilli S., Spillantini M.G., Amenta F. Substance P-like immunoreactivity in capsaicin-sensitive structures of the rat thymus. Regul. Peptides. 18:1987;323-329.
14. Jancso' N., Jancso'-Gabor A., Szlocsanyi J. Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin. Br. J. Pharmac. Chemother. 31:1967;138-151.
15. Jancso' G., Kirally E., Jancso'-Gabor A. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones. Nature. 270:1977;741-743.
16. Hartung H.P., Toyka K.V. Activation of macrophages by substance P: induction of oxidative burst and thromboxane release. Eur. J. Pharm. 89:1983;301-305.
17. Hartung H.P., Walters K., Toyka K.V. Substance P: binding properties and studies on cellular responses in guinea pig macrophages. J. Immunol. 136:1986;3856-3863.
18. Helme R., Eglezos A., Dandie G.W., Andrews P.V., Boyd R.L. The effect of substance P on the regional lymphnode antibody response to antigenic stimulation in capsaicin-treated rats. J. Immunol. 139:1987;3470-3473.
19. Holzer P. Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience. 2:1988;739-768.
20. Holzer P. Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurones. Pharmacol. Rev. 43:1991;143-201.
21. Kimball E.S. Substance P, cytokines and arthritis. Ann. NY Acad. Sci. 594:1990;293-308.
22. Laurenzi M.A., Persson M.A.A., Dalsgaard C.J., Ringden O. Stimulation of human B lymphocyte differentiation by the neuropeptide substance-P and Neurokinin A. Scand. J. Immunol. 30:1989;695-701.
23. Laurenzi M.A., Persson M.A.A., Dalsgaard C.J., Haegerstrand A. The neuropeptide Substance P stimulates production of interleukin 1 in human blood monocytes: activated cells are preferentially influenced by the neuropeptide. Scand. J. Immunol. 31:1990;529-533.
24. Lorton D., Bellinger D.L., Felten S.Y., Felten D.L. Substance P innervation of the rat thymus. Peptides. 11:1990;1269-1275.
25. Lorton D., Bellinger D.L., Felten S.Y., Felten D.L. Substance P innervation of spleen in rats: nerve fibers associate with lymphocytes and macrophages in specific compartment of the spleen. Brain Behav. Immun. 5:1991;29-40.
26. Lotz M., Vaughan J.H., Carson D.A. Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Science. 241:1988;1218-1221.
27. Marasco W.A., Showell H.J., Becker E.L. Substance P binds to the formyl peptide chemotaxis receptor on the rabbit neutrophil. Biochem. Biophys. Res. Commun. 99:1981;1065-1077.
28. Moore T.C., Lami J.L., Spruck H.H. Substance P increases lymphocyte traffic and lymph flow through peripheral lymphnodes of sheep. Immunology. 67:1989;109-114.
29. Nilsson G., Ahlstedt S. Altered lymphocyte proliferation of immunized rats after neurological manipulation with capsaicin. Int. J. Immunopharmacol. 10:1988;747-751.
30. Nilsson G., Ahlstedt S. Increased delayed-type hypersensitivity reaction in rats neuromanipulated with capsaicin. Int. Arch. Allergy Appl. Immunol. 90:1989;256-260.
31. Nilsson G., Alving K., Ahlstedt S. Effects on immune responses in rats after neuroimmunomodulation with capsaicin. Int. J. Immunopharmacol. 13:1991;21-26.
32. Payan D.G., Brewster D.R., Goetzl E.J. Specific stimulation of human T lymphocytes by substance P. J. Immunol. 131:1983;1613-1615.
33. Payan D.G., Brewster D.R., Missirian-Bastian A., Goetzl E.J. Substance P recognition by a subset of human T lymphocytes. J. Clin. Invest. 74:1984;1532-1539.
34. Payan D.G., Levine J.D., Goetzl E.J. Modulation of immunity and hypersensitivity by sensory neuropeptides. J. Immunol. 132:1984;1601-1604.
35. Payan D.G., Goetzl E.J. Modulation of lymphocyte function by sensory neuropeptides. J. Immunol. 135:1985;783-786.
36. Pernow B. Substance P. Pharmacol. Rev. 35:1983;85-141.
37. Rameshwar P., Gasco P., Ganea D. Immunoregulatory effect of neuropeptides. Stimulation of interleukin-2 production by substance P. J. Neuroimmunol. 37:1992;65-74.
38. Rameshwar P., Gascon P., Ganea D. Stimulation of IL-2 production in murine lymphocytes by substance P and related tachykinins. J. Immunol. 151:1993;2484-2496.
39. Rameshwar P., Ganea D., Gascon P. Induction of IL-3 and granulocyte-macrophage-colony-stimulating factor by substance P in bone marrow cells is partially mediated through the release of IL-1 and IL-6. J. Immunol. 152:1994;4044-4054.
40. Ropke C., Elbroen J. Human thymic epithelial cells in serum free culture: nature and effects on thymic cell lines. Dev. Immunol. 2:1992;111-121.
41. Ruff M.R., Wahl S.M., Pert C.B. Substance P receptor-mediated chemotaxis of human monocytes. Peptides. 6:1985;107-112.
42. Santoni G., Perfumi M., Birarelli P., Procaccini S., Piccoli M. In vivo capsaicin treatment inhibits rat NK cell cytotoxic functions. Immunopharmacol. Immunotoxicol. 17:1995;511-528.
43. Scicchitano R., Biennestock J., Stanitz A.M. In vivo immunomodulation by neuropeptide substance P. Immunology. 63:1988;733-735.
44. Shigematsu K., Saavedra J.M., Kurihara M. Specific substance P binding sites in rat thymus and spleen: in vitro autoradiographic study. Regul. Pept. 16:1986;147-156.
45. Smith C.H., Barker J.N., Morris R.W., MacDonald D.M., Lee T.H. Neuropeptides induce rapid expression of endothelial cell adhesion molecules and elicit granulocytic infiltration in human skin. J. Immunol. 151:1993;3274-3282.
46. Stanisz A.M., Befus D., Bienenstock J. Differential effects of vasoactive intestinal peptide, substance P, and somatostatin on immunoglobulin synthesis and proliferation by lymphocytes from Peyer's patches, mesenteric lymphnodes, and spleen. J. Immunol. 136:1986;152-156.
47. Stanisz A.M., Scicchitano R., payan D.G., Bienenstock J. In vitro studies of immunoregulation by substance P and somatostain. Ann. NY Acad. Sci. 496P:1987;217-225.
48. Stanisz A.M., Scicchitano R., Darin P., Bienenstock J., Payan D.G. Distribution of substance P receptor on murine spleen and Peyer's patch T and B cells. J. Immunol. 139:1987;749-754.
49. Sudduth-Klinger J., Schumann M., Gardener P., Payan D.G. Functional and immunological responses of Jurkat lymphocytes transfected with the substance P receptor. Cell Mol. Neurobiol. 12:1992;379-395.
50. Wiedermann C.J., Sertl R., Pert C.B. Substance P receptors in rat spleen: characterization and autoradiographic distribution. Blood. 68:1986;1398-1401.