Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical carcinoma: Identification of a correlation between folate receptor expression and thymidine kinase activity

Cancer Research

Volumn 59, Issue 4, 1999, Pages 940-946

  Sun, Xin Lai ^a   Jayaram, Hiremagalur N ^a   Gharehbaghi, Kamran ^a   Li, Qing Jun ^a   Xiao, Xiangli ^a   Antony, Aśok C ^a,b,c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Richard L Roudeboush Vet Aff M   (United States)

^c Division of Hematology and Oncology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; COMPLEMENTARY DNA; FOLIC ACID; METHOTREXATE; THYMIDINE KINASE; ZIDOVUDINE;

ARTICLE; CANCER CHEMOTHERAPY; CANCER RESISTANCE; CELL PROLIFERATION; CHEMOSENSITIVITY; DRUG CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; UTERINE CERVIX CARCINOMA;

ANTIMETABOLITES, ANTINEOPLASTIC; CARRIER PROTEINS; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE TRANSFER TECHNIQUES; HUMANS; METHOTREXATE; RECEPTORS, CELL SURFACE; THYMIDINE; THYMIDINE KINASE; UTERINE CERVICAL NEOPLASMS; ZIDOVUDINE;

EID: 0033557927     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Antony, A. C. Folate receptors. Annu. Rev. Nutr., 16: 501-521, 1996.
2. Matsue, H., Rothberg, K. G., Takashima, A., Kamen, B. A., Anderson, R. G., and Lacey, S. W. Folate receptor allows cells to grow in low concentrations of 5-methyltetrahydrofolate. Proc. Natl. Acad. Sci. USA. 89: 6006-6009, 1992.
3. Luhrs, C. A., Raskin, C. A., Durhin, R., Wu, B., Sadasivan, E., McAllister, W., and Rothenberg, S. P. Transfection of a glycosylated phosphatidylinositol-anchored folate-binding protein complementary DNA provides cells with the ability to survive in low folate medium. J. Clin. Invest., 90: 840-847, 1992.
4. Bottero, F., Tomassetti, A., Canevari, S., Miotti, S., Menard, S., and Colnaghi, M. I. Gene transfection and expression of the ovarian carcinoma marker folate binding protein on NIH/3T3 cells increases cell growth in vitro and in vivo. Cancer Res., 53: 5791-5796, 1993.
5. Chung, K. N., Saikawa, Y., Paik, T. H., Dixon, K. H., Mulligan, T., Cowan, K. H., and Elwood, P. C. Stable transfectants of human MCF-7 breast cancer cells with increased levels of the human folate receptor exhibit an increased sensitivity to antifolates. J. Clin. Invest., 91: 1289-1294, 1993.
6. Antony, A. C., Bruno, E., Briddell, R. A., Brandt, J. E., Verma, R. S., and Hoffman, R. Effect of perturbation of specific folate receptors during in vitro erythropoiesis. J. Clin. Invest., 80: 1618-1623, 1987.
7. Antony, A. C., Briddell, R. A., Brandt, J. F., Straneva, J. E., Verma, R. S., Miller, M. E., Kalasinski, L. A., and Hoffman, R. Megaloblastic hematopoiesis in vitro. Interaction of anti-folate receptor antibodies with hematopoietic progenitor cells leads to a proliferative response independent of megaloblastic changes. J. Clin. Invest., 87: 313-325, 1991.
8. Sun, X. L., Murphy, B. R., Li, Q. J., Gullapalli, S., Mackins, J., Jayaram, H. N., Srivastava, A., and Antony, A. C. Transduction of folate receptor cDNA into cervical carcinoma cells using recombinant adeno-associated virions delays cell proliferation in vitro and in vivo J. Clin. Invest., 96: 1535-1547, 1995.
9. Chu, E., and Allegra, C. J. The role of thymidylate synthase in cellular regulation. Adv. Enzyme Regul., 36: 143-163, 1996.
10. Antony, A. C. Megaloblastic anemias. In: R. Hoffman, E. J. Benz, Jr., S. J. Shattil, B. Furie, H. J. Cohen, and L. E. Silberstein (eds.), Hematology. Basic Principles and Practice. Ed. 2. pp. 552-586. New York: Churchill Livingstone, 1995.
11. Sherley, J. L., and Kelly, T. J. Human cytosolic thymidine kinase. Purification and physical characterization of the enzyme from HeLa cells. J. Biol. Chem., 263: 375-382, 1988.
12. Elwood, P. C. Molecular cloning and characterization of the human folate-binding protein cDNA from placenta and malignant tissue culture (KB) cells. J. Biol. Chem., 264: 14893-14901, 1989.
13. Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., and Klenk, D. C. Measurement of protein using bicinchoninic acid [published erratum appears in Anal. Biochem., 163: 279, 1987]. Anal. Biochem., 150: 76-85, 1985.
14. Sambrook, J., Fritsch, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual, Ed. 2. New York: Cold Spring Harbor Laboratory, 1989.
15. Weber, G., Shiotanim T, Kizaki, H., Tzeng, D., Williams, J. C., and Gladstone, N. Biochemical strategy of the genome as expressed in regulation of pyrimidine metabolism. Adv. Enzyme Regul., 16: 3-19, 1978.
16. Hashimoto, Y., Shiotani, T., and Weber, G. Simple separation of tritiated water and [3H]deoxyuridine from [5-3H]deoxyuridine 5′-monophosphate in the thymidylate synthase assay. Anal. Biochem., 167: 340-346, 1987.
17. Rode, W., Scanlon, K. J., Moroson, B. A., and Bertino, J. R. Regulation of thymidylate synthetase in mouse leukemia cells (L1210). J. Biol. Chem., 255: 1305-1311, 1980.
18. Garrett, C., and Santi, D. V. A rapid and sensitive high pressure liquid chromatography assay for deoxyribonucleoside triphosphates in cell extracts. Anal. Biochem., 99: 268-273, 1979.
19. Zhen, W., Jayaram, H. N., and Weber, G. Determination of thiazole-4-carboxamide adenine dinucleotide (TAD) levels in mononuclear cells of leukemic patients treated with tiazofurin. Biochem. Pharmacol., 41: 281-286, 1991.
20. Jayaram, H. N., Zhen, W., and Gharehbaghi, K. Biochemical consequences of resistance to tiazofurin in human myelogenous leukemic K562 cells. Cancer Res., 53: 2344-2348, 1993.
21. Matthews, J. H., Shiels, S., and Wickramasinghe, S. N. The effects of folate deficiency on thymidylate synthetase activity, deoxyuridine suppression, cell size and doubling time in a cultured human myeloid cell line. Eur. J. Haematol., 45: 43-47, 1990.
22. Chello, P. L., McQueen, C. A., DeAngelis, L. M., and Bertino, J. R. Elevation of dihydrofolate reductase, thymidylate synthetase, and thymidine kinase in cultured mammalian cells after exposure to folate antagonists. Cancer Res., 36: 2442-2449, 1976.
23. Gao, W. Y., Shirasaka, T., Johns, D. G., Broder, S., and Mitsuya, H. Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells. J. Clin. Invest., 91: 2326-2333, 1993.
24. Allegra, C. J., Chabner, B. A., Drake, J. C., Lutz, R., Rodbard, D., and Jolivet, J. Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates. J. Biol. Chem., 260: 9720-9726, 1985.
25. Allegra, C. J., Fine, R. L., Drake, J. C., and Chabner, B. A. The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis. J. Biol. Chem., 261: 5478-6485, 1986.
26. Allegra, C. J., Hoang, K., Yeh, G. C., Drake, J. C., and Baram, J. Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate. J. Biol. Chem., 262: 13520-13526, 1987.
27. Bertino, J. R. Karnofsky memorial lecture. Ode to methotrexate. J. Clin. Oncol., 11: 5-14, 1993.
28. Pelka-Fleischer, R., Ruppelt, W., Wilmanns, W., Sauer, H., and Schalhorn, A. Relation between cell cycle stage and the activity of DNA-synthesizing enzymes in cultured human lymphoblasts: investigations on cell fractions enriched according to cell cycle stages by way of centrifugal elutriation. Leukemia (Baltimore), 1: 182-187, 1987.
29. Moore, M. R., Hathaway, L. D., and Bircher, J. A. Progestin stimulation of thymidine kinase in the human breast cancer cell line T47D. Biochim. Biophys. Acta. 1096: 170-174, 1991.
30. Ho, C. K., Ou, B. R., Hsu, M. L., Su, S. N., Yung, C. H., and Wang, S. Y. Induction of thymidine kinase activity and clonal growth of certain leukemic cell lines by a granulocyte-derived factor. Blood, 75: 2438-2444, 1990.
31. Vazquez-Padua, M. A., Kunugi, K., Risueno, C., and Fischer, P. H. Modulation of the feedback regulation of thymidine kinase activity by pH in 647V cells. Cancer Res., 49: 5644-5649, 1989.
32. Maiman, M., Fruchter, R. G., Serur, E., Remy, J. C., Feuer, G., and Boyce, J. Human immunodeficiency virus infection and cervical neoplasia. Gynecol. Oncol., 38: 377-382, 1990.
33. Maiman, M., Fruchter, R. G., Guy, L., Cuthill, S., Levine, P., and Serur, E. Human immunodeficiency virus infection and invasive cervical carcinoma. Cancer (Phila.), 71: 402-405, 1993.
34. Maiman, M. Cervical neoplasia in women with HIV infection. Oncology, 8: 83-89, 1994.
35. Cannistra, S. A., and Niloff, J. M. Cancer of the uterine cervix. N. Engl. J. Med., 334: 1030-1038, 1996.
36. Omura, G. A. Chemotherapy for cervix cancer. Semin. Oncol., 21: 54-62, 1994.
37. Broder, S. Clinical applications of 3′-azido-2′,3′-dideo\ylhymidine (AZT) and related dideoxynucleosides. Med. Res. Rev., 10: 419-439, 1990.
38. Spinella, M. J., Brigle, K. E., Sierra, E. E., and Goldman, I. D. Distinguishing between folate receptor-α-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells. J. Biol. Chem., 270: 7842-7849, 1995.
39. Dixon, K. H., Mulligan, T., Chung, K. N., Elwood, P. C., and Cowan, K. H. Effects of folate receptor expression following stable transfection into wild type and methotrexate transport-deficient ZR-75-1 human breast cancer cells. J. Biol. Chem., 267: 24140-24147, 1992.
40. Miyachi, H., Jiao, L., Sowers, L. C., and Scanlon, K. J. Collateral sensitivity to azidothymidine in methotrexate resistant human leukemia cells. In Vivo, 6: 17-21, 1992.
41. Chabner, B. A., and Myers, C. E. Clinical pharmacology of cancer therapy. In: V. T. DeVita, S. Hellman, and S. A. Rosenberg (eds.), Cancer Principles and Practice of Oncology, Ed. 3, pp. 349-395. Philadelphia: J. B. Lippincott Co., 1989.
42. Gorlick, R., Goker, E., Trippelt, T., Steinherz, P., Elisseyeff, Y., Mazumdar, M., Flintoff, W. F., and Bertino, J. R. Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression. Blood, 89: 1013-1018, 1997.
43. Oldfield, E. H., Ram, Z., Culver, K. W., Blaese, R. M., DeVroom, H. L., and Anderson, W. F. Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum. Gene Ther., 4: 39-69, 1993.
44. Culver, K. W., Van Gilder, J., Link, C. J., Carlstrom, T., Buroker, T., Yuh, W., Koch, K., Schabold, K., Doornbas, S., Wetjen, B., and Blaese, M. R. Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system. Hum. Gene Ther., 5: 343-379, 1994.
45. Colak, A., Goodman, J. C., Chen, S. H., Woo, S. L., Grossman, R. G., and Shine, H. D. Adenovirus-mediated gene therapy in an experimental model of breast cancer metastatic to the brain. Hum. Gene Ther., 6: 1317-1322, 1995.
46. Yoshida, K., Kawami, H., Yamaguchi, Y., Kuniyasu, H., Nishiyama, M., Hirai, T., Yanagihara, K., Tahara, E., and Toge, T. Retrovirally transmitted gene therapy for gastric carcinoma using herpes simplex virus thymidine kinase gene. Cancer (Phila.), 75: 1467-1471, 1995.
47. Smythe, W. R., Hwang, H. C., Elshami, A. A., Amin, K. M., Eck, S. L., Davidson, B. L., Wilson, J. M., Kaiser, L. R., and Albelda, S. M. Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene. Ann. Surg., 222: 78-86, 1995.
48. Vile, R. G., Nelson, J. A., Castleden, S., Chong, H., and Hart, I. R. Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component. Cancer Res., 54: 6228-6234, 1994.
49. Wang, S., Lee, R. J., Cauchon, G., Gorenstein, D. G., and Low, P. S. Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol. Proc. Natl. Acad. Sci. USA, 92: 3318-3322, 1995.
50. Lee, R. J., and Low, P. S. Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro. Biochim. Biophys. Acta, 1233: 134-144, 1995.
51. Lee, R. J., and Huang, L. Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer. J. Biol. Chem., 271: 8481-8487, 1996.