Novel splicing of the human MHC-encoded peptide transporter confers unique properties

Journal of Immunology

Volumn 162, Issue 2, 1999, Pages 852-859

  Yan, Gang ^a   Shi, Lijia ^a   Faustman, Denise ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; GENE PRODUCT; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MESSENGER RNA; T LYMPHOCYTE RECEPTOR;

ALTERNATIVE RNA SPLICING; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE TARGETING; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN TARGETING; PROTEIN TRANSPORT; T LYMPHOCYTE;

ADULT; ALTERNATIVE SPLICING; ATP-BINDING CASSETTE TRANSPORTERS; BASE SEQUENCE; BIOLOGICAL TRANSPORT; CELL LINE; ENDOPLASMIC RETICULUM; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN ISOFORMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0033556173     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Deverson, E. V., I. R. Gow, W. J. Coadwell, J. J. Monaco, G. W. Butcher, and J. C. Howard. 1990. MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters. Nature 348:738.
2. Trowsdale, J., I. Hanson, I. Mockridge, S. Beck, A. Townsend, and A. Keily. 1990. Sequences encoded in the class II region of the MHC related to the "ABC" superfamily of transporters. Nature 348:741.
3. Monaco, J. J., S. Cho, and M. Attaya. 1990. Transport protein genes in the murine MHC: possible implications for antigen processing. Science 250:1723.
4. Spies, T., M. Bresnahan, S. Bahram, D. Arnold, G. Blanck, E. Mellins, D. Plous, and R. DeMars. 1990. A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway. Nature 348: 744.
5. Bahram, S., D. Arnold, M. Bresnahan, J. L. Strominger, and T. Spies. 1991. Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region. Proc. Natl. Acad. Sci. USA 88:10094.
6. Neefjes, J. J., F. Momburg, and G. J. Hammerling. 1993. Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter. Science 261:769.
7. Shepherd, J. C., T. N. Schumacher, R. P. Ashton, S. Imaeda, H. L. Ploegh, C. J. Janeway, and S. Tonegawa. 1993. TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective. [Published erratum appears in 1993 Cell 75:613.] Cell 74:577.
8. androlewicz, M. J., and P. Cresswell. 1994. Human transporters associated with antigen processing possess a promiscuous peptide-binding site. Immunity 1:7.
9. Momburg, F., J. Roelse, G. J. Hammerling, and J. J. Neefjes. 1994. Peptide size selection by the major histocompatibility complex-encoded peptide transporter. J. Exp. Med. 179:1613.
10. g7 (NOD/Lt) haplotype translocate similar sets of peptides. Proc. Natl. Acad. Sci. USA 91:13004.
11. Van Endert, P. M., R. Tampe, T. H. Meyer, R. Tisch, J. F. Bach, and H. O. McDevitt. 1994. A sequential model for peptide binding and transport by the transporters associated with antigen processing. Immunity 1:491.
12. Momburg, F., J. Roelse, J. C. Howard, G. W. Butcher, G. J. Hammerling, and J. J. Neefjes. 1994. Selectivity of MHC encoded peptide transporters from human, mouse and rat. Nature 367:648.
13. Powis, S. J., L. L. Young, E. Joly, P. J. Barker, L. Richardson, R. P. Brandt, C. J. Melief, J. C. Howard, and G. W. Butcher. 1996. The rat cim effect: TAP allele-dependent changes in a class I MHC anchor motif and evidence against C-terminal trimming of peptides in the ER. Immunity 4:159.
14. Powis, S. J., J. C. Howard, and G. W. Butcher. 1991. The major histocompatibility complex class II-linked cim locus controls the kinetics of intracellular transport of a classical class I molecule. J. Exp. Med. 173:913.
15. Powis, S. J., E. V. Deverson, W. J. Coadwell, A. Ciruela, N. S. Huskisson, H. Smith, G. W. Butcher, and J. C. Howard. 1992. Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule. Nature 357:211.
16. Heemels, M. T., T. N. Schumacher, K. Wonigeit, and H. L. Ploegh. 1993. Peptide translocation by variants of the transporter associated with antigen processing. Science 262:2059.
17. Marusina, K., M. Iyer, and J. J. Monaco. 1997. Allelic variation in the mouse Tap-1 and Tap-2 transporter genes. J. Immunol. 158:5251.
18. Lobigs, M., and A. Mullbacher. 1993. Recognition of vaccinia virus-encoded major histocompalibility complex class I antigens by virus immune cytotoxic T cells is independent of the polymorphism of the peptide transporters. Proc. Natl. Acad. Sci. USA 90:2676.
19. Obst, R., E. A. Armandola, M. Nijenhuis, F. Momburg, and G. J. Hammerling. 1995. TAP polymorphism does not influence transport of peptide variants in mice and humans. Eur. J. Immunol. 25:2170.
20. Neefjes, J., E. Gottfried, J. Roelse, M. Gromme, R. Obst, G. J. Hammerling, and F. Momburg. 1995. Analysis of the fine specificity of rat, mouse and human TAP peptide transporters. Eur. J. Immunol. 25:1133.
21. Daniel, S., S. Caillat-Zucman, J. Hammer, J. F. Bach, and P. M. Van Endert. 1997. Absence of functional relevance of human transporter associated with antigen processing polymorphism for peptide selection. J. Immunol. 159:2350.
22. Chen, H. L., D. Gabrilovich, R. Tampe, K. R. Girgis, S. Nadaf, and D. P. Carbone. 1996. A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer. Nat. Genet. 13:210.
23. Fu, Y., D. M. Nathan, F. Li, X. Li, and D. L. Faustman. 1993. Defective major histocompatibility complex class I expression on lymphoid cells in autoimmunity. J. Clin. Invest. 91:2301.
24. Beck, S., A. Kelly, E. Radley, F. Khurshid, R. P. Alderton, and J. Trowsdale. 1992. DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing. J. Mol. Biol. 228:433.
25. Ma, W., P. J. Lehner, P. Cresswell, J. S. Pober, and D. R. Johnson. 1997. Interferon-γ rapidly increases peptide transporter (TAP) subunit expression and peptide transport capacity in endothelial cells. J. Biol. Chem. 272:16585.
26. 2-micro-globulin complexes associated with Tap transporters before peptide binding. Nature 368:864.
27. Cerundolo, V., A. Kelly, T. Elliott, J. Trowsdale, and A. Townsend. 1995. Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport. Eur. J. Immunol. 25:554.
28. Pazmany, L., S. Rowland-Jones, S. Huet, A. Hill, J. Sutton, R. Murray, J. Brooks, and A. McMichael. 1992. Genetic modulation of antigen presentation by HLA-B27 molecules. J. Exp. Med. 175:361.
29. Rowland-Jones, S. L., S. H. Powis, J. Sutton, I. Mockridge, F. M. Gotch, N. Murray, A. B. Hill, W. M. Rosenberg, J. Trowsdale, and A. J. McMichael. 1993. An antigen processing polymorphism revealed by HLA-B8-restricted cytotoxic T lymphocytes which does not correlate with Tap gene polymorphism. Eur. J. Immunol. 23:1999.
30. Simmons, W. A., D. C. Roopenian, S. G. Summerfield, G. J. Christianson, S. D. Maika, M. Zhou, S. J. Gaskell, R. S. Bordoli, H. L. Ploegh, C. A. Slaughter, K. F. Lindahl, R. E. Hammer, and J. D. Taurog. 1997. A new MHC locus that influences class I peptide presentation. Immunity 7:641.
31. Heemels, M. T., and H. L. Ploegh. 1994. Substrate specificity of allelic variants of the TAP peptide transporter. Immunity 1:775.
32. Momburg, F., E. A. Armandola, M. Post, and G. J. Hammerling. 1996. Residues in TAP-2 peptide transporters controlling substrate specificity. J. Immunol. 156: 1756.
33. Deverson, E. V., L. Leong, A. Seelig, W. J. Coadwell, E. M. Tredgett, G. W. Butcher, and J. C. Howard. 1998. Functional analysis by site-direct mutagenesis of the complex polymorphism in rat transporter associated with antigen processing. J. Immunol. 160:2767.
34. Nijenhuis, M., and G. J. Hammerling. 1996 Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site. J. Immunol. 157:5467.
35. Wang, P., G. Gyllner, and S. Kvist. 1996. Selection and binding of peptides to human transporters associated with antigen processing and rat cim-a and -b. J. Immunol. 157:213.
36. Armandola, E. A., F. Momburg, M. Nijenhuis, N. Bulbuc, K. Fruh, and G. J. Hammerling. 1996. A point mutation in the human transporter associated with antigen processing (TAP2) alters the peptide transport specificity. Eur. J. Immunol. 26:1748.
37. Uebel, S., W. Kraas, S. Kienle, K. H. Wiesmuller, G. Jung, and R. Tampe. 1997. Recognition principle of the TAP transporter disclosed by combinatorial peptide libraries. Proc. Natl. Acad. Sci. USA 94:8976.
38. Faustman, D., X. Li, H. Y. Lin, Y. Fu, G. Eisenbarth, J. Avruch, and J. Guo. 1991. Linkage of faulty major histocompatibility complex class I to autoimmune diabetes. Science 254:1756.