Novel hypotensive agents from Verbesina caracasana. 6. Synthesis and pharmacology of caracasandiamide

Journal of Medicinal Chemistry

Volumn 42, Issue 16, 1999, Pages 3116-3125

  Carmignani, Marco ^a   Volpe, Anna R ^b   Delle Monache, Franco ^b   Botta, Bruno ^c   Espinal, Romulo ^d   De Bonnevaux, Stella C ^d   De Luca, Carlo ^e   Botta, Maurizio ^f   Corelli, Federico ^f   Tafi, Andrea ^f   Ripanti, Giuseppe ^a   Delle Monache, Giuliano ^b  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSIDAD DE CARABOBO   (Venezuela)

^e Ctro Elettrochimica Chim Fis I   (Italy)

^f UNIVERSITY OF SIENA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(3,4 DIMETHOXYCINNAMOYL)AMINO] 4 [(3 METHYL 2 BUTENYL)GUANIDINO]BUTANE; 3,4 DIMETHOXYCINNAMIC ACID; ANTIHYPERTENSIVE AGENT; BETA TRUXINIC ACID; CARACASANDIAMIDE; CYCLOBUTANE; GUANIDINE DERIVATIVE; METHANOL; PINACIDIL; PRENYLAGMATINE; UNCLASSIFIED DRUG;

ADRENERGIC NERVE; ANIMAL EXPERIMENT; AORTA FLOW; ARTICLE; BLOOD PRESSURE; CARBON NUCLEAR MAGNETIC RESONANCE; DIMERIZATION; DRUG EFFECT; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; HEART OUTPUT; HEART STROKE VOLUME; HYPOTENSION; INOTROPISM; NERVE CONDUCTION; NONHUMAN; PRESSORECEPTOR REFLEX; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SIGNAL TRANSDUCTION; SYNTHESIS; VASCULAR RESISTANCE;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CYCLOBUTANES; GUANIDINES; HEART RATE; HYDROLYSIS; INJECTIONS, INTRAVENOUS; MALE; PLANT EXTRACTS; RATS; RATS, WISTAR; RESPIRATORY MECHANICS; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; STROKE VOLUME; TIDAL VOLUME; VENTRICULAR PRESSURE;

EID: 0033549899     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm991004l     Document Type: Article

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