Caracasandiamide, a truxinic hypotensive agent from verbesina caracasana

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 3, 1996, Pages 233-238

  Delle Monache, Giuliano ^a   Botta, Bruno ^a   Delle Monache, Franco ^a   Espinal, Romulo ^b   De Bonnevaux, Stella C ^b   De Luca, Carlo ^c   Botta, Maurizio ^d   Corelli, Federico ^d   Dei, Donata ^d   Gacs Baitz, Eszter ^e   Carmignani, Marco ^f  

^a CATHOLIC UNIVERSITY   (Italy)

^b UNIVERSIDAD DE CARABOBO   (Venezuela)

^c Centro Elettrochimica d Chimica Fisica delle Interfasi   (Italy)

^d UNIVERSITY OF SIENA   (Italy)

^e CTRL RES INSTITUTE FOR CHEMISTRY   (Hungary)

^f UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; CARACASANAMIDE; CARACASANDIAMIDE; TRUXINIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; HEART RATE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHOTOCHEMISTRY; PLANT; RAT; VASCULAR RESISTANCE;

EID: 0030038386     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00007-8     Document Type: Article

References (14)

1. Dedicated to Professor Giovanni Battista Marini Bettolo in occasion of his 80th birthday. Part 3 in the series: Novel Hypotensive Agents from Verbesina caracasana. For part 2 see ref. 3.
2. Delle Monache, G.; Botta, B.; Delle Monache, F.; Espinal, R.; De Bonnevaux, S. C.; De Luca, C.; Botta, M.; Corelli, F.; Carmignani, M. BioMed Chem. Lett. 1992, 2, 415
3. Delle Monache, G.; Botta, B.; Delle Monache, F.; Espinal, R.; De Bonnevaux, S. C.; De Luca, C.; Botta, M.; Corelli, F.; Carmignani, M. J. Med. Chem. 1993, 36, 2956.
4. + (57).
5. Ishigami, T.; Murata, T.; Endo, T. Bull. Chem. Soc. Jap. 1976, 49, 3578.
6. Green, B. S., Reito, M.; Johnson,D. E.; Hoyle, C. E.; Ho, T.-J.; McCoy, F.; Lewis, F. D. J. Am. Chem. Soc. 1979, 101, 3325.
7. + (46), 191 [Ar-CH=CHCO] (100).
8. Oelrichs, P.B.; Vallely, P.J.; MacLeod, J.K.; Lewis, I.A.S. J. Nat. Prod. 1981, 754.
9. + (100); m*351.5 (413 → 381), 270.8 (300 → 285), 193.0 (222 → 207), 164.3 (222 → 191).
10. Lewis, F.D.; Quillen, S.L.; Hale, P.D.; Oxman, J.D. J. Am. Chem. Soc. 1988, 110, 1261.
11. Bernstein, H.I.; Quimby, W.C. J. Am. Chem. Soc. 1943, 65, 1845.
12. No other steroisomer was found in the plant extract; thus, caracasandiamide must be a natural product and not a photodimerization artefact.
13. 2, Pd-C).
14. Delle Monache, G; Delle Monache, F.: Botta, B.; De Bonnevaux, S. C.; Espinal R.; De Luca, C.; Carmignani, M. Eur. Pal. n. 0330629 A3., Feb 17, 1989; U.S. Pat. n. 5,059,624, Oct 22, 1991.