Conformational analysis of febrifugines and halofuginones in organic solvents

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 1, 1998, Pages 1-5

  Uesato, Shinichi ^a   Kuroda, Yoshihiro ^b   Kato, Masahiro ^c   Fujiwara, Yasuhiro ^d   Hase, Yasunori ^e   Fujita, Tetsuro ^f  

^a KANSAI UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c DAIICHI SANKYO CO   (Japan)

^d KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^e JAPAN TOBACCO INC   (Japan)

^f SETSUNAN UNIVERSITY   (Japan)

Author keywords

AM1 molecular orbital calculation; Anticoccidial agent; Coccidia; Febrifugine; Halofuginone; Plasmodia

Indexed keywords

FEBRIFUGINE; HALOFUGINONE; ORGANIC SOLVENT;

ANALYTIC METHOD; ANTIMALARIAL ACTIVITY; ARTICLE; COCCIDIA; DRUG CONFORMATION; DRUG EFFICACY; DRUG ISOLATION; ISOMERISM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PLASMODIUM; STEREOCHEMISTRY;

EID: 0031884934     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.1     Document Type: Article

References (14)

1. Koepfli J. B., Mead J. F., Brockman J. A., Jr., J. Am. Chem. Soc., 69, 1837-1838 (1947).
2. Ablondi F., Gordon S., Morton J., Williams J. H., J. Org. Chem., 17, 14-18 (1952).
3. Baker B. R., Schaub R. E., McEvoy F. J., Williams J. H., J. Org. Chem., 17, 132-140 (1952).
4. a) Baker B. R., Schaub R. E., McEvoy F. J., Williams J. H., J. Org. Chem., 18, 153-177 (1953);
5. b) Baker B. R., McEvoy F. J., Schaub R. E., Joseph J. P., Williams J. H., ibid., 18, 178-183 (1953).
6. Barringer D. F., Jr., Berkelhammer G., Wayne R. S., J. Org. Chem., 38, 1937-1940 (1973).
7. Kato M., Inaba M., Itahana H., Ohara E., Nakamura K., Uesato S., Inouye H., Fujita T., Shoyakugaku Zasshi, 44, 288-292 (1990).
8. Unpublished data.
9. a) Waletzky E., Berkelhammer G., Kantor S., U. S. 3,320,124 (Cl. 167-53), 16 May 1967, Appl. 20 July, 1964; [Chem. Abstr., 68, P39647v (1968)];
10. b) Idem, U.S. Re-Issue 26, 833 (Cl.424-251; A 61K), 24 Mar 1970, Appl. 15 May 1968; [Chem. Abstr., 72, P121574k (1970)].
11. Jolly J., Rizzi P., Grandadam J. A., Ger. Offen, 2,703,652 (Cl. C07D 401/06), 04 Aug 1977, Fr. Appl. 76/2,413, 29 Jan 1976; [Chem. Abstr., 87, P184543e (1977)].
12. Koepfli J.B., Mead J. F., Brockman J. A., Jr., J. Am. Chem. Soc., 71, 1048-1054 (1949).
13. Barringer D. F., Jr., Berkelhammer G., Carter S. D., Goldman L., Lanzilotti A. E., J. Org. Chem., 38, 1933-1936 (1973).
14. Dewar M. J. S., Zoebisch E. G., Healy E. F., Stewart J. J. P., J. Am. Chem. Soc., 107, 3902-3909 (1985).