Solid phase synthesis of oligonucleotide phosphorothioate analogues using 3-methyl-1,2,4-dithiazolin-5-one (MEDITH) as a new sulfur-transfer reagent

Tetrahedron Letters

Volumn 40, Issue 11, 1999, Pages 2095-2098

  Zhang, Zhaoda ^a,b   Nichols, Alexandra ^a   Tang, Jimmy X ^a   Han, Yonxin ^a   Tang, Jin Yan ^a  

^a HYBRIDON INC   (United States)

^b EPIX Medical Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYL 1,2,4 DITHIAZOLIN 5 ONE; OLIGONUCLEOTIDE; PHOSPHOROTHIOIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CAPILLARY ELECTROPHORESIS; DISULFIDE BOND; DNA SYNTHESIS INHIBITION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEOTIDE METABOLISM; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; SOLID PHASE EXTRACTION; STRUCTURE ACTIVITY RELATION;

EID: 0033548666     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)00154-9     Document Type: Article

References (21)

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19. 3) δ 189.5, 186.5, 22.7.
20. O-Ethyl-thiocarbamate is not commercially available. See Chem Sources-USA, 1998 Edition.
21. Beaucage reagent (1) was purchased from R. I. Chemical (Orange, CA); EDITH (2) was purchased from PerSeptive Biosystems (Framingham, Ma).