Solid phase synthesis of oligonucleotide phosphorothioate analogues using bis(ethoxythiocarbonyl)tetrasulfide as a new sulfur-transfer reagent

Tetrahedron Letters

Volumn 39, Issue 17, 1998, Pages 2467-2470

  Zhang, Zhaoda ^a,b   Nichols, Alexandra ^a   Alsbeti, Mazen ^a   Tang, Jimmy X ^a   Tang, Jin Yan ^a  

^a HYBRIDON INC   (United States)

^b EPIX Medical Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIS(ETHOXYTHIOCARBONYL)TETRASULFIDE; OLIGONUCLEOTIDE; PHOSPHOROTHIOIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; AUTOMATION; BINDING KINETICS; BINDING SITE; CHEMICAL BINDING; NUCLEOTIDE METABOLISM; PROTEIN STABILITY; REACTION TIME; SOLID PHASE EXTRACTION; SULFATION;

EID: 0032560048     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00307-4     Document Type: Article

References (13)

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11. 12. Prolonged storage of Beaucage reagent in acetonitrile may cause the formation of precipitates and an inferior sulfurization efficiency.
12. 3) δ 4.68 (m, 4H), 1.45 (m, 6H).
13. 7 were prepared by literature's procedure; bis(p-toluenesulfonyl)disulfide (6) was provided by Aronex Pharmaceuticals (The Woodlands, TX).