Patofysiologien bag det aldersrelaterede knogletab: Ny indsigt i cellulære og molekylærbiologiske mekanismer

Ugeskrift for Laeger

Volumn 161, Issue 41, 1999, Pages 5663-5666

  Kassem, Moustapha S ^a   Mosekilde, Leif ^b   Eriksen, Erik F ^b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; ESTROGEN;

AGED; AGING; ARTICLE; BONE DENSITY; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; OSTEOBLAST; OSTEOPOROSIS; PATHOPHYSIOLOGY; POSTMENOPAUSE OSTEOPOROSIS;

AGED; AGING; BONE DENSITY; CALCIUM; ESTROGENS; FEMALE; HUMANS; MALE; MIDDLE AGED; OSTEOBLASTS; OSTEOPOROSIS; OSTEOPOROSIS, POSTMENOPAUSAL;

EID: 0033547097     PISSN: 00415782     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. WHO Study Group. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Geneva: World Health Organisation, 1994.
2. Manolagas SC, Jilka RL. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 1995; 832: 305-11.
3. Jilka RL, Hangoc G, Griasole G et al. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 1992; 257: 88-91.
4. Kassem M, Khosla S, Spelsberg TC, Riggs BL. Cytokine production in the bone marrow microenvironment: failure to demonstrate estrogen regulation in early postmenopausal women. J Clin Endocrinol Metab 1996; 81: 513-8.
5. Simonet WS, Lucy DL, Kelley M et al. Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. CELL 1997; 89: 309-19.
6. Kassem M, Ankersen L, Eriksen EF, Clark BFC, Rattan SIS. Demonstration of cellular aging and senescence in serially passaged long-term cultures of human trabecular osteoblasts. Osteoporos Int 1997; 7: 514-24.
7. Otto F, Thornell AP, Crompton T et al. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 1997; 89: 765-71.
8. Eiken P, Kolthoff N, Pors Nielsen S. Effect of 10 years' hormone replacement therapy on bone mineral content in postmenopausal women. Bone 1996; 19 suppl: 191S-93S.
9. McKane WR, Khosla S, Burritt MF et al. Mechanism of renal calcium conservation with estrogen replacement therapy in women in early postmenopause. J Clin Endocrinol Metab 1995; 80: 3458-64.
10. Riggs BL, Khosla S, Melton LJ. A unitary model for involutional osteoporosis: Estrogen deficiency causes both type I and type II osteopoprosis in postmenopausal women and contributes to bone loss in aging men. j Bone Miner Res 1998; 13: 763-73.