In vitro characterisation of Ro 46-8443, the first non-pep tide antagonist selective for the endothelin ETB receptor

FEBS Letters

Volumn 383, Issue 1-2, 1996, Pages 37-41

  Breu, Volker ^a   Clozel, Martine ^a   Burri, Kaspar ^a   Hirth, Georges ^a   Neidhart, Werner ^a   Ramuz, Henri ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Endothelin; Endothelin antagonist; Endothelin ETA; Endothelin ETB; Receptor

Indexed keywords

4 TERT BUTYL N [6 (2,3 DIHYDROXYPROPOXY) 5 (2 METHOXYPHENOXY) 2 (4 METHOXYPHENOXY)PYRIMIDIN 4 YL]BENZENESULFONAMIDE; ARACHIDONIC ACID; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; RES 701 1; RES 701 3; RO 46 8443; SARAFOTOXIN S6C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BACULOVIRUS; CELL MEMBRANE; CHO CELL; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INSECT; MESANGIUM CELL; NONHUMAN; NORMAL HUMAN; PLACENTA; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; SWINE; TRACHEA; VASCULAR RING; VASCULAR SMOOTH MUSCLE;

ANIMALS; ARACHIDONIC ACID; BINDING, COMPETITIVE; CELL MEMBRANE; CHO CELLS; CRICETINAE; HUMANS; MICROSOMES; MOLECULAR STRUCTURE; MUSCLE CONTRACTION; PROTEIN BINDING; PYRIMIDINES; RATS; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN; RECEPTORS, PEPTIDE; RECOMBINANT PROTEINS; SULFONAMIDES; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VIPER VENOMS;

ANIMALIA; INSECTA; SUS SCROFA; UNIDENTIFIED BACULOVIRUS;

EID: 0029862675     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-5793(96)00213-X     Document Type: Article

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