A post-transcriptional compensatory pathway in heterozygous ventricular myosin light chain 2-deficient mice results in lack of gene dosage effect during normal cardiac growth or hypertrophy

Journal of Biological Chemistry

Volumn 274, Issue 15, 1999, Pages 10066-10070

  Minamisawa, Susumu ^a   Gu, Yusu ^a   John Jr , Ross ^a   Chien, Kenneth R ^a   Chen, Ju ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; MUSCLE PROTEIN; MYOSIN HEAVY CHAIN; MYOSIN LIGHT CHAIN;

AORTA CONSTRICTION; ARTICLE; GENE DOSAGE; GENE TARGETING; GENETIC TRANSCRIPTION; HEART DEVELOPMENT; HEART FUNCTION; HEART HYPERTROPHY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE; HETEROZYGOTE; KNOCKOUT GENE; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CARDIAC MYOSINS; CARDIOMEGALY; ECHOCARDIOGRAPHY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE DOSAGE; HEART; MICE; MICE, KNOCKOUT; MYOCARDIAL CONTRACTION; MYOSIN LIGHT CHAINS; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EUKARYOTA; MURINAE;

EID: 0033537842     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.15.10066     Document Type: Article

References (27)

1. Beall, C. J., Sepanski, M. A., and Fyrberg, E. A. (1989) Genes Dev. 3, 131-140
2. Jones, W. K., Grupp, I. L., Doetschman, T., Grupp, G., Osinska, H., Hewett, T. E., Boivin, G., Gulick, J., Ng, W. A., and Robbins, J. (1996) J. Clin. Invest. 98, 1906-1917
3. Blanchard, E. M., Iizuka, K., Christe, M., Conner, D. A., Geisterfer, L. A., Schoen, F. J., Maughan, D. W., Seidman, C. E., and Seidman, J. G. (1997) Circ. Res. 81, 1005-1010
4. Rethinasamy, P., Muthuchamy, M., Hewett, T., Boivin, G., Wolska, B. M., Evans, C., Solaro, R. J., and Wieczorek, D. F. (1998) Circ. Res. 82, 116-123
5. Allen, B. G., and Walsh, M. P. (1994) Trends Biochem. Sci. 19, 362-368
6. Moussavi, R. S., Kelley, C. A., and Adelstein, R. S. (1993) Mol. Cell. Biochem. 128, 219-227
7. Somlyo, A. P., and Somlyo, A. V. (1994) Nature 372, 231-236
8. Sweeney, H. L., Bowman, B. F., and Stull, J. T. (1993) Am. J. Physiol. 264, C1085-C1095
9. Lowey, S., Waller, G. S., and Trybus, K. M. (1993) Nature 365, 454-456
10. Diffee, G. M., Greaser, M. L., Reinach, F. C., and Moss, R. L. (1995) Biophys. J. 68, 1443-1452
11. Szczesna, D., Zhao, J., and Potter, J. D. (1996) J. Biol. Chem. 271, 5246-5250
12. Chen, J., Kubalak, S. W., Minamisawa, S., Price, R. L., Becker, K. D., Hickey, R., Ross, J., Jr., and Chien, K. R. (1998) J. Biol. Chem. 273, 1252-1256
13. Poetter, K., Jiang, H., Hassanzadeh, S., Master, S. R., Chang, A., Dalakas, M. C., Rayment, I., Sellers, J. R., Fananapazir, L., and Epstein, N. D. (1996) Nat. Genet. 13, 63-69
14. Warmke, J., Yamakawa, M., Molloy, J., Falkenthal, S., and Maughan, D. (1992) J. Cell Biol. 119, 1523-1539
15. Chen, J., Kubalak, S., and Chien, K. (1998) Development (Camb.) 125, 1943-1949
16. Tanaka, N., Dalton, N., Mao, L., Rockman, H. A., Peterson, K. L., Gottshall, K. R., Hunter, J. J., Chien, K. R., and Ross, J., Jr. (1996) Circulation 94, 1109-1117
17. Rockman, H. A., Rosa, R. S., Harris, A. N., Knowlton, K. U., Steinhelper, M. E., Field, L. J., Ross, J., Jr., and Chien, K. R. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 8277-8281
18. Kubalak, S. W., Miller-Hance, W. C., O'Brien, T. X., Dyson, E., and Chien, K. R. (1994) J. Biol. Chem. 269, 16961-16970
19. Solaro, R. J., Pang, D. C., and Briggs, F. N. (1971) Biochim. Biophys. Acta. 245, 259-262
20. Sata, M., Sugiura, S., Yamashita, H., Momomura, S., and Serizawa, T. (1996) Circulation 93, 310-317
21. Ikebe, M., and Hartshorne, D. J. (1985) Biochemistry 24, 2380-2387
22. Palermo, J., Gulick, J., Colbert, M., Fewell, J., and Robbins, J. (1996) Circ. Res. 78, 504-509
23. Thierfelder, L., Watkins, H., MacRae, C., Lamas, R., McKenna, W., Vosberg, H. P., Seidman, J. G., and Seidman, C. E. (1994) Cell 77, 701-712
24. Kumar, A., Crawford, K., Close, L., Madison, M., Lorenz, J., Doetschman, T., Pawlowski, S., Duffy, J., Neumann, J., Robbins, J., Boivin, G. P., O'Toole, B. A., and Lessard, J. L. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 4406-4411
25. Sucov, H. M., Dyson, E., Gumeringer, C. L., Price, J., Chien, K. R., and Evans, R. M. (1994) Genes Dev. 8, 1007-1018
26. Rajewsky, K., Gu, H., Kuhn, R., Betz, U. A., Muller, W., Roes, J., and Schwenk, F. (1996) J. Clin. Invest. 98, 600-603
27. Hirota, H., Chen, J., Betz, V. A., Rajewsky, K., Gu, Y., Ross, J., Jr., Muller, W., and Chien, K. R. (1999) Cell, in press