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85034151314
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note
-
The use of NaOAc was found to be essential for efficient dibromide formation. Unambiguous stereochemical assignment of C6 by NMR spectroscopy was not possible.
-
-
-
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44
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85034153349
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note
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All new compounds were fully characterized spectroscopically. The identity of the dibromide was further proven by elemental analysis.
-
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-
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46
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85034155862
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note
-
(a) Phorbol numbering is used for all derivatives. (b) The ability of the C9 hydroxyl to act as a coordinating/activating group in a related stereoselective ketone reduction has been utilized in the total synthesis of phorbol: see ref 6b.
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47
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85034141055
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See ref 1b
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See ref 1b.
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