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Volumn 1, Issue 7, 1999, Pages 1009-1012

A new class of simplified phorbol ester analogues: Synthesis and binding to PKC and ηPKC-C1B (ηPKC-CRD2)

Author keywords

[No Author keywords available]

Indexed keywords

PHORBOL ESTER; PROTEIN KINASE C;

EID: 0033533637     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol990809k     Document Type: Article
Times cited : (8)

References (50)
  • 5
    • 0023052241 scopus 로고
    • (a) Nishizuka, Y. Science 1986, 233, 305-312.
    • (1986) Science , vol.233 , pp. 305-312
    • Nishizuka, Y.1
  • 9
    • 0023764824 scopus 로고
    • (a) Nishizuka, Y. Nature 1988, 334, 661-665.
    • (1988) Nature , vol.334 , pp. 661-665
    • Nishizuka, Y.1
  • 11
    • 0003799677 scopus 로고
    • Oxford University Press: New York
    • (c) Kuo, J. F., Ed. Protein Kinase C; Oxford University Press: New York, 1994.
    • (1994) Protein Kinase C
    • Kuo, J.F.1
  • 43
    • 85034151314 scopus 로고    scopus 로고
    • note
    • The use of NaOAc was found to be essential for efficient dibromide formation. Unambiguous stereochemical assignment of C6 by NMR spectroscopy was not possible.
  • 44
    • 85034153349 scopus 로고    scopus 로고
    • note
    • All new compounds were fully characterized spectroscopically. The identity of the dibromide was further proven by elemental analysis.
  • 46
    • 85034155862 scopus 로고    scopus 로고
    • note
    • (a) Phorbol numbering is used for all derivatives. (b) The ability of the C9 hydroxyl to act as a coordinating/activating group in a related stereoselective ketone reduction has been utilized in the total synthesis of phorbol: see ref 6b.
  • 47
    • 85034141055 scopus 로고    scopus 로고
    • See ref 1b
    • See ref 1b.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.