Synthesis of C2-symmetric bis(cyclic isothioureas) as potent inhibitors of glycosidases

Tetrahedron Letters

Volumn 40, Issue 19, 1999, Pages 3705-3708

  Gauzy, Laurence ^a   Le Merrer, Yves ^a   Depezay, Jean Claude ^a   Damour Barbalat, Dominique ^b   Mignani, Serge ^b  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b SANOFI   (France)

Author keywords

Glycosidase; Isothiourea; Mercuric chloride; Thiazolidinethione; Thioformamide

Indexed keywords

1,3 THIAZOLIDINE 2 THIONE; 2 N TERT BUTYLAMINO 1,3 THIAZOLINE; BIS(2 AMINO 1,3 THIAZOLINE); GLYCOSIDASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; DRUG CONFORMATION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

EID: 0033531983     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)00593-6     Document Type: Article

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25. 2N), 54.8 (CHS), 73.7 (CHO), 176.0 (C=N).
26. 2S), 67.6 (CHN), 74.6 (CHO), 177.3 (C=N).