The alpha-2 macroglobulin gene is not associated with Alzheimer's disease in a case-control sample

Neuroscience Letters

Volumn 270, Issue 3, 1999, Pages 133-136

  Crawford, Fiona ^a   Town, Terrence ^a   Freeman, Melissa ^a   Schinka, John ^a   Gold, Michael ^b   Duara, Ranjan ^c   Mullan, Mike ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c UNIVERSITY OF MIAMI   (United States)

Author keywords

Amyloid; Alpha 2 macroglobulin; Alzheimer's disease; Genetic association

Indexed keywords

ALPHA 2 MACROGLOBULIN;

AGED; ALZHEIMER DISEASE; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENE DELETION; GENETIC ASSOCIATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

AGED; ALLELES; ALPHA-MACROGLOBULINS; ALZHEIMER DISEASE; CASE-CONTROL STUDIES; FEMALE; GENE DELETION; GENOTYPE; HUMANS; INTRONS; LIKELIHOOD FUNCTIONS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; REFERENCE VALUES; SEX CHARACTERISTICS;

EID: 0033529933     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00470-X     Document Type: Article

References (20)

1. Bauer J., Strauss S., Schreiter-Gasser U., Schlegel P., Witt I., Yolk B., Berger M. Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices. FEBS Lett. 285:1991;111-114.
2. Blacker D., Wilcox M.A., Laird N.M., Rodes L., Horvath S.M., Go R.C.P., Perry R., Watson B., Bassett S.S., McInnis M.G., Albert M.S., Hyman B.T., Tanzi R.E. Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nat. Genet. 19:1998;357-360.
3. Blacker D., Crystal A.S., Wilcox M.A., Laird N.M., Tanzi R.E. Response to Nature Genetics correspondence on α-2 macroglobulia and Alzheimer disease. Nat. Genet. 22:1999;21-22.
4. Dodel R.C., Bales K.R., Farlow M.R., Gasser T., Paul S.M., Du Y. Rapid detection of a pentanucleotide deletion polymorphism in the human α2-macroglobulin gene. Clin. Chem. 45:1999;307-317.
5. Dow D.J., Lindsey N., Cairns N.J., Brayne C., Robinson D., Huppert F.A., Paykel E.S., Xureb J., Wilcock G., Whittaker J.L., Rubiusztein D.C. α-2 macroglobulia polymorphism and Alzheimer disease risk in the UK. Nat. Genet. 22:1999;16-17.
6. Ganter U., Strauss S., Jonas U., Weidemann A., Beyreuther K., Volk B., Berger M., Bauer J. Alpha 2-macroglobulin synthesis in interleukin-6-stimulated human neuronal (SH-SY5Y neuroblastoma) cells. Potential significance for the processing of Alzheimer beta-amyloid precursor protein. FEBS Lett. 282:1991;127-131.
7. Hughes S.R., Khorkova O., Goyal S., Knaeblein J., Heroux J., Riedel N.G., Sahasrabudhe S. α2-macroglobulin associates with beta-amyloid peptide and prevents fibril formation. Proc. Natl. Acad. Sci., USA. 95:1998;3275-3280.
8. Hyman B.T., Strickland D.K., Rebeck G.W. Alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Relationship to apolipoprotein E and role in Alzheimer disease senile plaques. Ann. N.Y. Acad. Sci. 737:1994;88-95.
9. Liao A., Nitsch R.M., Greenberg S.M., Finckh U., Blacker D., Albert M., Rebeck G.W., Gomez-Isla T., Clatworthy A., Binetti G., Hock C., Mueller-Thomsen T., Mann U., Zuchowski K., Beisiegel U., Staehelin H., Growdon J.H., Tanzi R.E., Hyman B.T. Genetic association of an α2 macroglobulin (Val1000Ile) polymorphism and Alzheimer's disease. Hum. Mol. Gen. 7:1998;1953-1956.
10. Matthijs G., Marynen P. A deletion polymorphism in the human alpha-2-macroglobulin (A2M) gene. Nucl. Acids Res. 19:1991;5102.
11. Narita M., Holtzman D.M., Schwartz A.L., Bu G. α2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein. J. Neurochem. 69:1997;1904-1911.
12. Pericak-Vance M.A., Bass M.P., Yamaoka L.H., Gaskell P.C., Scott W.K., Terwedow H.A., Menold M.M., Conneally P.M., Small G.W., Vance J.M., Saunders A.M., Roses A.D., Haines J.L. Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. J. Am. Med. Assoc. 278:1997;1237-1241.
13. Rebeck G.W., Harr S.D., Strickland D.K., Hyman B.T. Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein. Ann. Neurol. 37:1995;211-217.
14. Rogaeva E., Premkumar S., Song Y., Sorbi S., Brindle N., Paterson A., Duara R., Levesque G., Yu G., Nishimura M., Ikeda M., O'Toole C., Kawarai T., Jorge R., Vilarino D., Bruni A.C., Farrer L.A., St. George-Hyslop P.H. Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity. J. Am. Med. Assoc. 280:1998;614-618.
15. Rogaeva E.A., Premkumar S., Grubber J., Serneels L., Scott W.K., Kawarai T., Song Y., Hill D.M., Abou-Donia S.M., Martin E.R., Vance J.J., Yu G., Orlacchio A., Pel Y., Nishimura M., Supala A., Roberge H., Saunders A.M., Roses A.D., Schmechel D., Crane-Gutherum A.C., Sorbi S., Bruol A., Small G.W., Conneally P.M., Haines J.L., Van Leuveu F., St. George-Hyslop F.H., Farrer L.A., Pericak-Vauce M.A. An α-2- mucrogiobulin insertion-deletion polymorphism in Alzheimer disease. Nat. Genet. 22:1999;19-21.
16. Rudrasingham V., Wavrant-DeVrieze F., Lambert J.C., Chakraverty S., Kehoe P., Crook R., Amouyel P., Wu W., Rice F., Perez-Tur J., Frigard B., Morris J.C., Carty S., Petersen R., Cottel D., Tunstall N., Holmans P., Lovestone S., Chartier-Harlin M.C., Goate A., Hardy J., Owen M.J., Williams J. α-2 macroglobulin gene and Alzheimer disease. Nat. Genet. 22:1999;17-19.
17. Tooyama I., Kawamata T., Akiyama H., Moestrup S.K., Gliemann J., McGeer P.L. Immunohistochemical study of alpha 2 macroglobulin receptor in Alzheimer and control postmortem human brain. Mol. Chem. Neuropathol. 18:1993;153-160.
18. Wavrant-DeVrieze F., Rudrasingham V., Lambert J.C., Chakraverty S., Kehoe P., Crook R., Amouyel P., Wu W., Holmans P., Rice F., Perez-Tur J., Frigard B., Morris J.C., Carty S., Cottel D., Tunstall N., Lovestone S., Petersen R.C., Chartier-Harlin M.C., Goate A., Owen M.J., Williams J., Hardy J. No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease. Neurosci. Lett. 262:1999;137-139.
19. Wenham P., Price W., Blundell G. Apolipoprotein E genotyping by one-stage PCR. Lancet. 337:1991;1158-1159.
20. Wood J.A., Wood P.L., Ryan R. Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1 beta or IL-1RA but increases in the associated acute phase proteins IL-6, alpha 2-macroglobulin and C-reactive protein. Brain Res. 629:1993;245-252.