No interaction of GABA(A) alpha-1 subunit and dopamine receptor D4 exon 3 genes in symptomatology of major psychoses

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 88, Issue 1, 1999, Pages 44-49

  Serretti, Alessandro ^a   Macciardi, Fabio ^a   Cusin, Cristina ^a   Lattuada, Enrico ^a   Lilli, Roberta ^a   Di Bella, Daniela ^a   Catalano, Marco ^a   Smeraldi, Enrico ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Delusional disorder; Dopamine receptors; GABA; Gene interaction; Mood disorder; Schizophrenia

Indexed keywords

DOPAMINE 4 RECEPTOR; RECEPTOR SUBUNIT;

4 AMINOBUTYRIC ACID RELEASE; ADULT; ALPHA CHAIN; ARTICLE; DELUSION; EXON; FEMALE; GABAERGIC TRANSMISSION; GENETIC ASSOCIATION; HUMAN; INTERNEURON; MAJOR CLINICAL STUDY; MALE; NEUROTRANSMITTER RELEASE; PRIORITY JOURNAL; PSYCHOSIS; RECEPTOR GENE; SYMPTOMATOLOGY;

ADULT; ANALYSIS OF VARIANCE; COHORT STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PSYCHOTIC DISORDERS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; RECEPTORS, GABA-A; SEQUENCE ANALYSIS, DNA;

EID: 0033525034     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19990205)88:1<44::AID-AJMG8>3.0.CO;2-Y     Document Type: Article

References (36)

1. American Psychiatric Association. 1987. Diagnostic and statistical manual of mental disorders, Third Edition-Revised. Washington, DC: American Psychiatric Association. p 273-391.
2. Busatto GF, Pilowsky LS, Costa DC, Ell PJ, David AS, Lucey JV, Kerwin RW. 1997. Correlation between reduced in vivo benzodiazepine receptor binding and severity of psychotic symptoms in schizophrenia. Am J Psychiatry 154:56-63.
3. A receptor subunit genes. Psychiatr Genet 5:23-29.
4. Catalano M, Nobile M, Novelli E, Nöthen MM, Smeraldi E. 1993. Distribution of novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients. Biol Psychiatry 34:459-464.
5. Cheverud JM, Routman EJ. 1995. Epistasis and its contribution to genetic variance components. Genetics 139:1453-1461.
6. Cloninger CR. 1994. Turning point in the design of linkage studies of schizophrenia. Am J Med Genet (Neuropsychiatr Genet) 54:83-92.
7. Comings DE. 1997. Polygenic inheritance in psychiatric disorders. In: Blum K. Noble EP, editors. Handbook of psychiatric genetics. Boca Raton, FL: CRC Press.
8. Comings DE, Wu S, Chiu C, Ring RH, Gade R, Ahn C, MacMurray JP, Dietz G, Muhleman D. 1996. Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder: The additive and subtractive effect of the three dopaminergic genes-DRD2, D beta H, and DAT1. Am J Med Genet 67:264-288.
9. A receptor subunit genes in multiplex pedigrees with manic depression. Psychiatr Genet 4:185-191.
10. De Bruyn A, Souery D, Mendelbaum K, Mendlewicz J, Van Broeckhoven C. 1996. A linkage study between bipolar disorder and genes involved in dopaminergic and GABAergic neurotransmission. Psychiatr Genet 6: 67-73.
11. Dixon WJ. 1990. BMDP statistical software manual. Berkeley: University of California Press. p 1135-1159
12. Ebstein RP, Segman R, Benjamin J, Osher Y, Nemanov L, Belmaker RH. 1997. 5-HT2C serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: Interaction with dopamine D4 receptor and dopamine D3 receptor polymorphisms. Am J Med Genet 74:65-72.
13. Fijneman RJA, de Vries SS, Jansen RC and Demant P. 1996. Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc2 and Sluc4, that influence the susceptibility to lung cancer in the mouse. Nat Genet 14:465-467.
14. Frankel WN, Schork NJ. 1996. Who's afraid of epistasis? Nat Genet 14: 371-373.
15. Ginsburg B, Werick T, Escobar J, Kugelmass S. 1996. Molecular genetics of psychopathologies: A search for simple answers to complex problems. Behav Genet 26:325-333.
16. Grigorenko EL, Wood FB, Meyer MS, Hart LA, Speed WC, Shuster A, Pauls DL. 1997. Susceptibility loci for distincts components of developmental dyslexia on chromosomes 6 and 15. Am J Hum Genet 60:27-39.
17. Johnson KJ, Sander T, Hicks AA, Van Marle A, Janz D, Mullan MJ, Riley BP, Darlison MG. 1992. Confirmation of the localization of the human GABA-A 1 subunit gene (GABRA 1) to distal 5q by linkage analysis. Genomics 14:745-748.
18. Korpi ER, Kleingoor C, Kettenmann H, Seeburg PH. 1993. Benzodiazepine-induced motor impairment linked to point mutation in cerebellar GABA-A receptor. Nature 361:356-359.
19. Lahiri DK, Nurnberger JI Jr. 1991. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res 19:5444.
20. Macciardi F, Cavallini MC. 1993. A 2-locus model for Alzheimer's disease? Genet Epidemiol 10:437-442.
21. Macciardi F, Petronis A, Van Tol M, Marino C, Cavallini M, Smeraldi E, Kennedy J. 1999. Analysis of the D4 dopamine receptor gene variant in an Italian schizophrenia kindred. Arch Gen Psychiatry 51:288-293.
22. McGuffin P, Farmer A, Harvey I. 1991. A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Arch Gen Psychiatry 48:764-770.
23. Morabito A, Macciardi F. 1988. Possible use of logistic models in studying schizophrenic genetic disorders. In: Smeraldi E. Bellodi L, editors. A Genetic Perspective for Schizophrenia and Related Disorders. Milan: Edi Ermes. pp 23-41.
24. Mrzljak L, Bergson C, Pappy M, Huff R, Levenson R, Goldman-Rakic PS. 1996. Localization of dopamine D4 receptors in GABAergic neurons of the primate brain. Nature 381:245-248.
25. Neuman RJ, Rice JP. 1992. Two-locus models of disease. Genet Epidemiol 9:347-365.
26. Petty F. 1995. GABA and mood disorders: A brief review and hypothesis. J Affective Disord 34:275-281.
27. Pritchett DB, Seeburg PH. 1991. γ-aminobutiric acid type A receptor point mutation increases the affinity of compounds for the benzodiazepines site. Proc Natl Acad Sci USA 88:1421-1425.
28. Risch N. 1990. Linkage strategies for genetically complex traits: I. Multilocus models. Am J Med Genet 46:222-228.
29. Sabatino M, Cannizzaro C, Flugy A, Gagliand M, Mineo A, Cannizzaro G. 1994. NMDA-GABA interactions in an animal model of behaviour: A gating mechanism from motivation toward psychotic-like symptoms. Eur Neuropsychopharmacol 4:103-109.
30. Serretti A, Macciardi F, Smeraldi E. 1996. Identification of symptomatologic patterns common to major psychoses: Proposal for a phenotype definition. Am J Med Genet 67:393-400.
31. Serretti A, Macciardi F, Catalano M, Bellodi L, Smeraldi E. 1999. Genetic variants of dopamine receptor D4 and psychopathology. Schizophr Bull, in press.
32. Tsuang MT, Faraone SV. 1990. The Genetics of Mood Disorders. Baltimore: The Johns Hopkins University Press. pp 1-30.
33. Van Tol HHM, Bunzow JR, Guan HC, Sunahara RK, Seeman P, Niznik HB, Civelli O. 1991. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 350: 610-614.
34. Van Wezel T, Stassen APM, Moen CJA, Hart AAM, Van der Valk MA, Demant P. 1996. Gene interaction and single gene effects in colon tumour susceptibility in mice. Nat Genet 14:468-470.
35. Wafford KA, Burnett DM, Leidenheimer NJ, Burt DR, Wang JB, Kofuji P, Dunwiddie TV, Harris RA, Sikela JM. 1991. Ethanol sensitivity of the GABA-A receptor expressed in Xenopus oocytes requires 8 amino acids contained in the γ2L subunit. Neuron 7:27-33.
36. Walsh C, Hicks AA, Sham P, Castle D, Hunt N, Clements A, Sander T, Murray R, Darlison MG, Gill M. 1992. GABA-A receptor subunits genes as candidate genes for bipolar affective disorder: An association analysis. Psychiatr Genet 2:239-247.