Design, combinatorial chemical synthesis and in vitro characterization of novel urea based gelatinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 19, 1999, Pages 2823-2826

  Zhang, Yingsheng ^a   Li, Dongmei ^b   Houtman, Jon C ^b   Witiak, Donald T ^a   Seltzer, Jo ^c   Bertics, Paul J ^b   Lauhon, Charles T ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE; GELATINASE INHIBITOR; HYDROXAMIC ACID; MATRIX METALLOPROTEINASE INHIBITOR; UREA DERIVATIVE;

ARTICLE; BASEMENT MEMBRANE; DRUG ACTIVITY; DRUG ANALYSIS; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG SOLUBILITY; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

DRUG DESIGN; ENZYME INHIBITORS; HYDROXAMIC ACIDS; MATRIX METALLOPROTEINASE 2; MOLECULAR STRUCTURE; UREA;

EID: 0033523624     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00498-9     Document Type: Article

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