Intranasal immunization with recombinant gD2 reduces disease severity and mortality following genital challenge with herpes simplex virus type 2 in guinea pigs

Vaccine

Volumn 17, Issue 18, 1999, Pages 2229-2236

  O'Hagan, Derek ^a   Goldbeck, Cheryl ^a   Ugozzoli, Mildred ^a   Ott, Gary ^a   Burke, Rae Lyn ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Guinea pigs; Herpes simplex virus type 2; Intravaginal challenge; LTK63 adjuvant

Indexed keywords

ESCHERICHIA COLI ENTEROTOXIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOLOGICAL ADJUVANT; N ACETYLMURAMYLALANYL DEXTRO ISOGLUTAMINYLALANYL DIPALMITOYLPHOSPHATIDYLETHANOLAMINE; RECOMBINANT VACCINE; VIRUS GLYCOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENITAL HERPES; GUINEA PIG; HERPES SIMPLEX VIRUS 2; IMMUNIZATION; INTRAMUSCULAR DRUG ADMINISTRATION; INTRANASAL DRUG ADMINISTRATION; MORTALITY; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; VAGINA;

ADMINISTRATION, INTRANASAL; ANIMALS; FEMALE; GUINEA PIGS; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; RECOMBINANT PROTEINS; VIRAL ENVELOPE PROTEINS; VIRAL VACCINES;

EID: 0033522403     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(99)00009-2     Document Type: Article

References (30)

1. Nahmias A.J., Lee F.K., Beckman-Nahmias S. Sero-epidemiological and sociological patterns of herpes simplex virus infection in the world. Scand. J. Infect. Dis. Suppl. 69:1990;19-36.
2. Corey L., Kolmes K.K. Genital herpes simplex infections: current concepts in diagnosis, therapy and prevention. Ann. Int. Med. 98:1983;973-983.
3. Johnson R.E., Nahmias A.J., Magder L.S., Lee F.K., Brooks C.A., Snowden C.B. A seroepidemiologic survey of the presence of herpes simplex virus type 2 infection in the United States. N. Engl. J. Med. 321:1989;7-12.
4. Johnson R.M., Spear P.G. Herpes simplex virus glycoprotein D mediated interference with herpes simplex virus infections. J. Virol. 63:1989;819-827.
5. Sanchez-Pescador L., Burke R.L., Ott G., Van Nest G. The effect of adjuvants on the efficacy of a recombinant herpes simplex virus glycoprotein vaccine. J. Immunol. 141:1988;1720-1727.
6. Gallichan W.S., Rosenthal K.L. Long-term immunity and protection against herpes simplex virus type 2 in the murine female genital tract after mucosal but not systemic immunization. J. Infect. Dis. 177:1998;1155-1161.
7. Straus S., Corey L., Burke R.L., Savarese B., Barnum G., Krause P.R., Kost R.G., Meier J.L., Sekulovich R., Adair S.F., Dekker C.L. Placebo-controlled trial of vaccination with recombinant glycoprotein D of herpes simplex virus type 2 for immunotherapy of genital herpes. Lancet. 343:1994;1460-1463.
8. Stuve L.L., Brown-Shimer S., Pachl C., Najarian R., Dina D., Burke R.L. The structure and expression of herpes simplex virus type 2 glycoprotein gB2 gene. J. Virol. 61:1987;326-335.
9. Douce G., Turcotte C., Cropley I., Roberts M., Pizza M., Domenghini M., Rappuoli R., Dougan G. Mutants of Escherichia coli heat labile enterotoxin lacking ADP-ribosyl transferase activity act as non-toxic mucosal adjuvants. Proc. Natl. Acad. Sci. USA. 92:1995;1644-1648.
10. Di Tommaso A., Saletti G., Pizza M., Rappuoli R., Dougan G., Abrignani S., Douce G., De Magistris M.T. Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heal labile enterotoxin as a mucosal adjuvant. Infect. Immun. 64:1996;974-979.
11. Ugozzoli M., O'Hagan D.T., Ott G.S. Intranasal immunization of mice with herpes simplex virus type 2 recombinant gD2: the effect of adjuvants on mucosal and serum antibody responses. Immunol. 93:1998;563-571.
12. Renegar K.B., Small P.A. Passive transfer of local immunity to influenza virus infection by IgA antibody. J. Immunol. 146:1991;1972-1978.
13. Winner L.S. III, Mack J., Weltzin R., Mekalanos J.J., Kraehenbuhl J.P., Neutra M.R. New model for analysis of mucosal immunity: intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection. Infect. Immun. 59:1991;977-982.
14. Whaley K.J., Zeitlin L., Barrat R.A., Hoen T.E., Cone R.A. Passive immunization of the vagina protects mice against vaginal transmission of genital herpes infections. J. Infect. Dis. 169:1994;647-649.
15. Russell M.W., Moldoveanu Z., White P.L., Sibert G.J., Mestecky J., Michalek S.M. Salivary, nasal, genital and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the cholera toxin B subunit. Infect. Immun. 64:1996;1272-1283.
16. Bergquist C., Johansson E.L., Lagergard T., Holmgren J., Rudin A. Intranasal vaccination of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and the vagina. Infect. Immun. 65:1997;2676-2684.
17. Schmid D.S., Rouse B.T. The role of T cell immunity in control of herpes simplex virus. Curr. Top. Microbiol. Immunol. 179:1992;57-74.
18. Kuklin N.A., Dahesia M., Chun S., Rouse B.T. Role of mucosal imunity in herpes simplex virus infection. J. Immunol. 160:1998;5998-6003.
19. Posavad C.M., Koelle D.M., Shaughnessy M.F., Corey L. Severe genital herpes infections in HIV-infected individuals with impaired HSV-specific CD8+ cytotoxic T-lymphocyte activity. Proc. Natl. Acad. Sci. USA. 94:1997;10289-10294.
20. Koelle D.M., Posavad C.M., Barnum G.R., Johnson M.L., Frank J.M., Corey L. Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T-lymphocytes. J. Clin. Invest. 101:1998;1500-1508.
21. Partidos C.D., Pizza M., Rappuoli R., Steward M.W. The adjuvant effect of a non-toxic mutant of heat-labile enterotoxin of Escherichia coli for the induction of measles virus-specific CTL responses after intranasal co-immunization with a synthetic peptide. Immunol. 89:1996;483-487.
22. Neidelman J, Ott GS, O'Hagan DT. Mutants of heat labile enterotoxin from Escherichia coli as adjuvants for the induction of cytotoxic T lymphocytes. In: O'Hagan D, editor. Vaccine adjuvants: preparation methods and study protocols. Humana Press, 1999.
23. Stanberry L.R., Kern E.R., Richards J.T., Abbott T.M., Overall J.C. Jr. Genital herpes in guinea pigs: pathogenesis of the primary infection and description of recurrent disease. J. Infect. Dis. 146:1982;397-404.
24. Ashley R.L., Crisostomo F.M., Doss M., Sekulovich R.E., Burke R.L., Shaughnessy M., Corey L., Polissar N.L., Langenberg A.G. Cervical antibody responses to a herpes simplex virus type 2 glycoprotein subunit vaccine. J. Infect. Dis. 178:1998;1-7.
25. Kuper C.F., Koornstra P.J., Hameleers D.M., Biewenga J., Spit B.J., Duijvestijn A.M., van Breda Vriesman P.J., Sminia T. The role of nasopharyngeal lymphoid tissue. Immunol. Today. 13:1992;219-224.
26. Wira CR, Richardson J, Prabhala R. Endocrine regulation of mucosal immunity: effect of sex hormones and cytokines on the afferent and efferent arms of the immune system in the female reproductive tract. In: Ogra PL, Lamm ME, McGhee JR, Mestecky J, Strober W, Bienenstock J, editors. Handbook of mucosal immunology. San Diego: Academic Press, 1994. p. 705-18.
27. Thaparr M.A., Parr E.L., Bozzola J.J., Parr M.B. Secretory immune response in the mouse vagina after parenteral or intravaginal immunization with an immunostimulating complex (Iscom). Vaccine. 9:1991;129-133.
28. O'Hagan D.T., Rafferty D., McKeating J.A., Illum L. Vaginal immunization of rats with a synthetic peptide from human immunodeficiency virus envelope glycoprotein. J. Gen. Virol. 73:1992;2141-2145.
29. Haneberg B., Kendall D., Amerongen H.M., Apter F.M., Kraehenbuhl J.-P., Neutra M.R. Induction of specific immunoglobulin A in the small intestine, colon-rectum and vagina measured by a new method for collection of secretions from local mucosal surfaces. Infect. Immun. 62:1994;15-23.
30. Lehner T., Wang Y., Cranage M., Bergmeier L.A., Mitchell E., Tao L., Hall G., Dennis M., Cook N., Brookes R., Klavinskis L., Jones I., Doyle C., Ward R. Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques. Nature Med. 2:1996;767-775.