Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine under anaerobic conditions by reductively activated nitro 5-deazaflavin derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 15, 1999, Pages 2141-2144

  Mikata, Yuji ^a   Kishigami, Maki ^a   Nishida, Mamiko ^a   Yano, Shigenobu ^a   Kawamoto, Tetsuji ^b   Ikeuchi, Yoshihiro ^b   Yoneda, Fumio ^b,c  

^a NARA WOMEN'S UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c Fujimoto Pharmaceutical Corporation   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 DEAZAFLAVINE DERIVATIVE; DEOXYGUANOSINE DERIVATIVE;

ANAEROBIC METABOLISM; ARTICLE; CYCLIC POTENTIOMETRY; MOLECULAR INTERACTION; NUCLEOTIDE METABOLISM; OXIDATION REDUCTION REACTION;

EID: 0033517079     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00349-2     Document Type: Article

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22. -5 (M)) in 25% DMF containing 1.5 mM sodium citrate buffer solution for 4 hours resulted in about 30% degradation of 8-oxodGuo. The results suggest that competitive oxidation of 8-oxodGuo is accompanied with its generation from dGuo by reductively activated 3 and 4 and the yield of 8-oxodGuo from dGuo would be higher than is estimated from the results shown in Figure 2 and 3.
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