Novel quinolizidine salicylamide influenza fusion inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 15, 1999, Pages 2177-2180

  Yu, Kuo Long ^a   Ruediger, Edward ^b   Luo, Guangxiang ^a   Cianci, Christopher ^a   Danetz, Stephanie ^a   Tiley, Laurence ^a   Trehan, Ashok K ^a   Monkovic, Ivo ^a   Pearce, Bradley ^a   Martel, Alain ^b   Krystal, Mark ^a   Meanwell, Nicholas A ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^b Department of Chemistry   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; QUINOLIZIDINE DERIVATIVE; SALICYLAMIDE DERIVATIVE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; DRUG SYNTHESIS; INFLUENZA; INFLUENZA VIRUS A; NONHUMAN; VIRUS CELL INTERACTION;

ANIMALS; ANTIVIRAL AGENTS; CATTLE; CELLS, CULTURED; INFLUENZA A VIRUS; QUINOLIZINES; SALICYLAMIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; INFLUENZA A VIRUS; INFLUENZA VIRUS;

EID: 0033516898     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00361-3     Document Type: Article

References (10)

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2. Meanwell, N. A.; Krystal, M. Drug Discovery Today, 1996, 1, 316; ibid, 1996, 1, 388.
3. Meanwell, N. A.; Krystal, M. Drug Discovery Today, 1996, 1, 316; ibid, 1996, 1, 388.
4. Hay, A. J. Semin. Virology 1992, 3, 21.
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6. All the compounds in the Table 1 were screened for both H1 and H3 influenza viruses using the procedure described by Luo, G.; Colonno, R.; Krystal, M. Virology 1996, 226, 66.
7. Luo, G; Torri, A.; Harte, W. E.; Danetz, S.; Cianci, C.; Tiley, L.; Day, S.; Mullaney, D.; Yu, K.-L.; Quellet, C.; Dextraze, P.; Meanwell, N. A.; Colonno, R.; Krystal, M. J. Virol. 1997, 71, 4062.
8. Hadley, M. S.; King, F. D.; McRitchie, B; Turner, D. H.; Watts, E. A. J. Med. Chem. 1985, 28, 1843.
9. This starting material was purchased from Ryan Scientific but has been recently discontinued.
10. Cianci, C; Yu, K.-L.; Dischino, D. D.; Harte, W.; Deshpande, M.; Luo, G.; Colonno, R. J.; Meanwell, N. A.; Krystal, M. J. Virol. 1999, 73, 1785.