B-cell-specific coactivator OCA-B: Biochemical aspects, role in B-cell development and beyond

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 64, Issue , 1999, Pages 119-131

  Luo, Y ^a   Roeder, R G ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE; CELL MATURATION; CONFERENCE PAPER; GENETIC ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA INTERACTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; ARTICLE; B LYMPHOCYTE ACTIVATION; BIOCHEMICAL ANALYSIS; CELL CYCLE REGULATION; DNA MICROARRAY; DOWNSTREAM PROCESSING; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INACTIVATION; HUMAN; LYMPHANGIOGENESIS; LYMPHOCYTE PROLIFERATION; MOLECULAR RECOGNITION; MUTAGENESIS; NONHUMAN; PRE B LYMPHOCYTE; PROTEIN DOMAIN; PROTEIN INTERACTION; TRANSLATION INITIATION;

HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; INITIATION FACTOR; LYMPHOCYTE ANTIGEN RECEPTOR; OCTAMER TRANSCRIPTION FACTOR 2; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR PAX5;

EID: 0033510981     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.1999.64.119     Document Type: Conference Paper

References (68)

1. Babb R., Cleary M.A., and Herr W. 1997. OCA-B is a functional analog of VP16 but targets a separate surface of the OCT-1 POU domain. Mol. Cell. Biol. 17: 7295.
2. Barton M.C., Madani N., and Emerson B.M. 1993. The erythroid protein cGATA-1 functions with a stage-specific factor to activate transcription of chromatin-assembled β-globin genes. Genes Dev. 7: 1796.
3. Buss J.E., Solski P.A., Schaeffer J.P., MacDonald M.J., and Der C.J. 1989. Activation of the cellular proto-oncogene product p21Ras by addition of a myristylation signal. Science 243: 1600.
4. Cepek K.L., Chasman D.I., and Sharp P.A. 1996. Sequence-specific DNA binding of the B-cell-specific coactivator OCA-B. Genes Dev. 10: 2079.
5. Chasman D., Cepek K., Sharp P.A., and Pabo C.O. 1999. Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: Specific recognition of a protein-DNA interface. Genes Dev. 13: 2650.
6. Constantinescu A. and Schlissel M.S. 1997. Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development. J. Exp. Med. 185: 609.
7. Corcoran L. and Karvelas M. 1994. OCT-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation. Immunity 1: 635.
8. Corcoran L., Karvelas M., Nossal G., Ye Z., Jacks T., and Baltimore D. 1993. OCT-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Genes Dev. 7: 570.
9. Crane-Robinson C., Myers F.A., Hebbes T.R., Clayton A.L., and Thorne A.W. 1999. Chromatin immunoprecipitation assays in acetylation mapping of higher eukaryotes. Methods Enzymol. 304: 533.
10. Dariavach P., Williams G.T., Campbell K., Pettersson S., and Neuberger M.S. 1991. The mouse IgH 3′-enhancer. Eur. J. Immunol. 21: 1499.
11. Ernst P. and Smale S.T. 1995. Combinatorial regulation of transcription II: The immunoglobulin mu heavy chain gene. Immunity 1: 427.
12. Feldhaus A., Klug C., Arvin K., and Singh H. 1993. Targeted disruption of the OCT-2 locus in a B cell provides genetic ev-idence for two distinct cell type-specific pathways of octamer element-mediated gene activation. EMBO J. 12: 2763.
13. Fondell J.D., Guermah M., Malik S., and Roeder R.G. 1999. Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID. Proc. Natl. Acad. Sci. 96: 1959.
14. Ge H. and Roeder R.G. 1994. Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. Cell 78: 513.
15. Gold M.R. and DeFranco A.L. 1994. Biochemistry of B lymphocyte activation. Adv. Immunol. 55: 221.
16. Grant P.A., Thompson C.B., and Pettersson S. 1995. IgM receptor-mediated transactivation of the IgH 3′ enhancer couples a novel Elf-l-AP-1 protein complex to the developmental control of enhancer function. EMBO J. 14: 4501.
17. Gstaiger M., Georgiev O., van Leeuwen H., van der Vliet P., and Schaffner W. 1996. The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with OCT-l/OCT-2 factors, leading to differential promoter activation. EMBO J. 15: 2781.
18. Gstaiger M., Knoepfel L., Georgiev O., Schaffner W., and Hovens C.M. 1995. A B-cell coactivator of octamer-binding transcription factors. Nature 373: 360.
19. Herr W. and Cleary M.A. 1995. The POU domain: Versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain. Genes Dev. 9: 1679.
20. Iyer V.R., Eisen M.B., Ross D.T., Schuler G., Moore T., Lee J.C.F., Trent J.M., Staudt L.M., Hudson J., Jr., Boguski M.S., Lashkari D., Shalon D., Botstein D., and Brown P.O. 1999. The transcriptional program in the response of human fibroblasts to serum. Science 283: 83.
21. Ito M., Yuan C.X., Malik S., Gu W., Fondell J.D., Yamamura S., Fu Z.Y., Zhang X., Qin J., and Roeder R.G. 1999. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Mol. Cell 3: 361.
22. Jenuwein T. and Grosschedl R. 1991. Complex pattern of immunoglobulin mu gene expression in normal and transgenic mice: Nonoverlapping regulatory sequences govern distinct tissue specificities. Genes Dev. 5: 932.
23. Kaiser K. and Meisterernst M. 1996. The human general co-factors. Trends Biochem. Sci. 21: 343.
24. Kamps M.P., Corcoran L., LeBowitz J.H., and Baltimore D. 1989. The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of OCT-2. Mol. Cell. Biol. 10: 5464.
25. Kelsoe G. 1995. In situ studies of the germinal center reaction. Adv. Immunol. 60: 267.
26. Kim U., Qin X.-F., Gong S., Stevens S., Luo Y., Nussenzweig M.C., and Roeder R.G. 1996. The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for the normal production of immunoglobulin isotypes. Nature 383: 543.
27. Klemm J.D., Rould M.A., Aurora R., Herr W., and Pabo C.O. 1994. Crystal structure of the OCT-1 POU domain bound to an octamer site: DNA recognition with tethered DNA binding modules. Cell 77: 21.
28. Koh S.S., Ansari A.Z., Ptashne M., and Young R.A. 1998. An activator target in the RNA polymerase II holoenzyme. Mol. Cell 1: 895.
29. LaBella F., Sive H.L., Roeder R.G., and Heintz N. 1988. Cellcycle regulation of a human histone H2B gene is mediated by the H2B subtype-specific consensus element. Genes Dev. 2: 32.
30. Lieberson R., Ong J., Shi X., and Eckhardt L.A. 1995. Immunoglobulin gene transcription ceases upon deletion of a distant enhancer. EMBO J. 14: 6229.
31. Liu Y.J. and Banchereau J. 1996. The paths and molecular controls of peripheral B cell development. Immunologist 4: 55.
32. Luo Y. and Roeder R.G. 1995. Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. Mol. Cell. Biol. 15: 4115.
33. Luo Y., Fujii H., Gerster T., and Roeder R.G. 1992. A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors. Cell 71: 231.
34. Luo Y., Ge H., Stevens S., Xiao H., and Roeder R.G. 1998. Coactivation by OCA-B: Definition of critical regions and synergism with general cofactors. Mol. Cell. Biol. 18: 3803.
35. MacLennan I.C. 1994. Germinal centers. Annu. Rev. Immunol. 12: 117.
36. Madisen L. and Groudine M. 1994. Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells. Genes Dev. 8: 2212.
37. Malik S., Guermah M., and Roeder R.G. 1998. A dynamic model for PC4 coactivator function in RNA polymerase II transcription. Proc. Natl. Acad. Sci. 95: 2192.
38. Mayall T.P., Sheridan P.L., Montminy M.R., and Jones K.A. 1997. Distinct roles for P-CREB and LEF-1 in TCR alpha enhancer assembly and activation on chromatin templates in vitro. Genes Dev. 11: 887.
39. Melchers F., Haasner D., Grawunder U., Kalberer C., Karasuyama H., Winkler T.H., and Rolink A.G. 1994. Roles of IgH and L chains and of surrogate H and L chains in the development of cells of the B lymphocyte lineage. Annu. Rev. Immunol. 12: 209.
40. Melchers F., Rolink A.G., Grawunder U., Winkler T.H., Karasuyama H., Ghia P., and Andersson J. 1995. Positive and negative selection events during B lymphopoiesis. Curr. Opin. Immunol. 7: 214.
41. Mitchell P.J. and Tjian R. 1989. Transcriptional regulation in mammalian cells by sequence-specific DNA-binding proteins. Science 245: 371.
42. Mizushima-Sugano J. and Roeder R.G. 1986. Cell-type-specific transcription of an immunoglobulin kappa light chain gene in vitro. Proc. Natl. Acad. Sci. 83: 8511.
43. Myer V.E. and Young R.A. 1998. RNA polymerase II holoenzymes and subcomplexes. J. Biol. Chem. 273: 27757.
44. Nakshatri H., Nakshatri P., and Currie R.A. 1995. Interaction of OCT-1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter. J. Biol. Chem. 270: 19613.
45. Nielsen P.J., Georgiev O., Lorenz B., and Schaffner W. 1996. B lymphocytes are impaired in mice lacking the transcriptional coactivator Bob1/OCA-B/OBF1. Eur. J. Immunol. 26: 3214.
46. Oelgeschlager T., Tao Y., Kang Y.K., and Roeder R.G. 1998. Transcription activation via enhanced preinitiation complex assembly in a human cell-free system lacking TAFIIs. Mol. Cell 1: 925.
47. Ong J., Stevens S., Roeder R.G., and Eckhardt L.A. 1998. 3′ IgH enhancer elements shift synergistic interactions during B cell development. J. Immunol. 160: 4896.
48. Pettersson S., Cook G.P., Bruggemann M., Williams G.T., and Neuberger M.S. 1990. A second B cell-specific enhancer 3′ of the immunoglobulin heavy-chain locus. Nature 344: 165.
49. Pfisterer P., Zwilling S., Hess J., and Wirth T. 1995. Functional characterization of the murine homolog of the B cell-specific coactivator BOB.1/OBF.1. J. Biol. Chem. 270: 29870.
50. Pierani A., Heguy A., Fujii H., and Roeder R.G. 1990. Activation of octamer-containing promoters by either octamer binding transcription factor 1 (OTF-1) or OTF-2 and requirement of an additional B-cell specific component for optimal tran-scription of immunoglobulin promoters. Mol. Cell. Biol. 10: 6204.
51. Ptashne M. and Gann A.A. 1990. Activators and targets. Nature 346: 329.
52. Qin X.-F. 1998. "Regulation of B cell development and antibody immune responses by the B-cell-specific transcription coactivator OCA-B." Ph.D. thesis, Rockefeller University, New York, New York.
53. Qin X.-F., Reichlin A., Luo Y., Roeder R.G., and Nussenzweig M.C. 1998. OCA-B integrates B cell antigen receptor-, CD40L- and IL 4-mediated signals for the germinal center pathway of B cell development. EMBO J. 17: 5066.
54. Roeder R. G. 1991. The complexities of eukaryotic transcription initiation: Regulation of preinitiation complex assembly. Trends Biochem. Sci. 16: 402.
55. _. 1996. The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem. Sci. 21: 327.
56. _. 1998. Role of general and gene-specific cofactors in the regulation of eukaryotic transcription. Cold Spring Harb. Symp. Quant. Biol. 63: 201.
57. Ryan, A.K. and Rosenfeld M.G. 1997. POU domain family values: Flexibility, partnership, and developmental codes. Genes Dev. 11: 1207.
58. Sauter P. and Matthias P. 1998. Coactivator OBF-1 makes selective contacts with both the POU-specific domain and the POU homeodomain and acts as a molecular clamp on DNA. Mol. Cell. Biol. 18: 7397.
59. Schubart D.B., Rolink A., Kosco-Vilbois M.H., Botteri F., and Matthias P. 1996a. B-cell-specific coactivator OBF-1/OCAB/Bob-1 required for immune response and germinal center formation. Nature 383: 538.
60. Schubart D.B., Sauter P., Massa S., Friedl E.M., Schwarzenbach H., and Matthias P. 1996b. Gene structure and characterization of the murine homologue of the B cell-specific transcriptional coactivator DBF-1. Nucleic Acids Res. 24: 1913.
61. Segil N., Roberts S.B., and Heintz N. 1991. Mitotic phosphorylation of the OCT-1 homeodomain and regulation of OCT-1 DNA binding activity. Sciences 154: 1814.
62. Staudt L.M. and Lenardo M.J. 1991. Immunoglobulin gene transcription. Annu. Rev. Immunol. 9: 373.
63. Steger D.J. and Workman J.L. 1996. Remodeling chromatin structures for transcription: What happens to the histones? BioEssays 18: 875.
64. Strubin M., Newell J.W., and Matthias P. 1995. OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. Cell 80: 497.
65. Verrijzer C.P. and Tjian R. 1996. TAFs mediate transcriptional activation and promoter selectivity. Trends Biochem. Sci., 21: 338.
66. Verrijzer C.P., Alkema M.J., van Weperen W.W., van Leeuwen H.C., Strating M.J., and van der Vliet P.C. 1992. The DNA binding specificity of the bipartite POU domain and its subdomains. EMBO J. 11: 4993.
67. Wirth T., Pfisterer P., Annweiler A., Zwilling S., and Konig H. 1995. Molecular principles of Oct2-mediated gene activation in B cells. Immunobiology 193: 161.
68. Workman J.L. and Kingston R.E. 1998. Alteration of nucleosome structure as a mechanism of transcriptional regulation. Annu. Rev. Biochem. 67: 545.