Serum vascular endothelial growth factor is a predictor of invasion and metastasis in hepatocellular carcinoma

Journal of Experimental and Clinical Cancer Research

Volumn 18, Issue 4, 1999, Pages 511-517

  Li, X M ^a   Tang, Z T ^a   Qin, L X ^a   Zhou, J ^a   Sun, H C ^a  

^a ZHONGSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

Angiogenic factor; Microvascular density; Neoplasm; Prognostic marker

Indexed keywords

MESSENGER RNA; VASCULOTROPIN;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER SURGERY; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; MALE; METASTASIS; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR VASCULARIZATION;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; ENDOTHELIAL GROWTH FACTORS; FEMALE; GROWTH SUBSTANCES; HUMANS; LIVER DISEASES; LIVER NEOPLASMS; LYMPHOKINES; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0033509708     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Li L.D., Zhang S.W., Lu F.Z., Mu R., Sun X.D., Huang X.M., et al.: Research on characteristics of mortality spectrum and type composition of malignant tumors in China. Chin. J. Oncol., 19: 323-328, 1997.
2. Wingo P.A., Tong T., and Bolden S.: Cancer Statistics. C. A., 45: 8-30, 1995.
3. Tang Z.Y: Recent advances in clinical research of hepatocellular carcinoma in China. Chin. Med. J., 108: 568-570, 1995.
4. Tang Z.Y.: Studies on small hepatocellular carcinoma clinical aspect and molecular biology. Hepatol. Rapid Let. Rev., 1:XI-XVI, 1996.
5. Kohn E.C. and Liotta L.A.: Molecular insights into cancer invasion: strategies for prevention and intervention. Cancer Res., 55: 1856-1870, 1995.
6. Folkman J.: Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med., 1: 27-31, 1995.
7. Fidler I., Ellis L.: The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell, 79: 185-187, 1994.
8. Houck K.A., Ferrara N.W., Cachianes G., Li B., Leung D.W.: The vascular endothelial cell growth factor gene family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol. Endocrinol., 5: 1806-1814, 1991.
9. Senger D.R., van de Water L., Brown L.F., Nagy L.F., Yeo K.T., Berse B.: Vascular permeability factor (VPF. VEGF) in tumor biology. Cancer Metastasis Rev., 12: 303-324, 1993.
10. Ferrara N.: The role of vascular endothelial growth factor in pathological angiogenesis. Breast Cancer Res. Treat., 36: 127-137, 1995.
11. Li X.M., Tang Z.Y., Zhou G., Yie S.L., Liu Y.K.: Significance of vascular endothlial growth factor mRNA expression in invasion and matastasis of hepatocellular carcinoma. J. Exp. Clin. Cancer Res., 17: 13-17, 1998.
12. Warran R.S., Yuan H., Matli M.R., Gillett N.A., Ferrara N.: Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. Clin. Invest., 95: 1789-1797, 1995.
13. Shirai Y., Kawata S., Ito N., Tsushima H., Takaishi K., Kiso S. Matsuzawa Y.: Plasma transforming growth factor β1 in patients with hepatocellular carcinoma. Cancer, 73: 2275-2279, 1994.
14. Yamamoto Y., Toi M., Kondo S., Matsumoto T., Suzuki H., Kitamura M., Tsuruta K., Taniguchi T., Okamoto A., Mori T., Yoshita M., Ikeda T., Tominaga T.: Concentration of vascular endothelial growth factor in the sera of normal controls and cancer patients. Clin. Cancer Res., 2: 821-826, 1996.
15. Fujimoto K., Ichimori Y., Yamaguchi H., Arai K., Futami T., Ozono S.: Basic fibroblast growth factor as a candidate tumor marker for renal cell carcinoma. Jpn. J. Cancer Res., 86: 182-186, 1995.
16. Chomczysky P., Sacchi N.: Single-step method of RNA isolation by guanidinum thiocyanaye-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
17. White B.A.: PCR Protocols. In: T. Horikoshi, K. Deneberg, M. Volkenandt, T. Stadibauer, and P. Deneberg, Quantitative Measurement of Relative Gene Expression in Human Tumors, pp. 177-188. Totowa, New Jersey: Humana Press Inc., 1993.
18. Noonan K.E., Beck C., Holzmayer T.A., Chin J.E., Wunder J.S., Andrulis I.L., Gazdar A. F., William C. I., Griffith B., Von Hoff D.D., Roninson I.B.: Quantitation analysis of MDR1 gene expression in human tumor by polymerase chain reaction. Proc. Natl. Acad. Sci. USA, 87: 7160-7164, 1990.
19. Holthofer H., Virtanen I., Kariniemi A.L., Hormia M., Linder E., Miettinen M.: Ulex europeaus 1 lectin as a marker for vascular endothelium in human tissue. Lab. Invest., 47: 60-66, 1982.
20. Rofstad E.K.: Orthotopic human melanoma xenograft model systems for studies of tumor angiogenesis, pathophysiology, treatment sensitivity and metastatic pattern. Br. J. Cancer, 70: 804-812, 1994.
21. Mise M., Arh S., Higshituji H., Furutani M., Niwano M., Harada T., Ishigami S., Toda Y., Nakayama H., Fukumoto M., Fujita J., Imamura M.: Clinical significantce of vascular endothelial growth factor and basic fibroblast growth factor gene expression in liver tumor. Hepatology, 23: 455-464, 1996.
22. Takano S., Yoshii Y., Kondo S., Susuki H., Maruno T., Shirai S., Nose T.: Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients. Cancer Res., 56: 2185-2190, 1996.
23. Salven P., Maenpaa H., Orpanp A., Alitalo K., Joensuu H.: Serum vascular endothelial growth factor is often elevated in disseminated cancer. Clin. Cancer Res., 3: 647-651, 1997.
24. Jinno K., Tanimisu M., Hyodo I., Nishikawa Y., Endo H., Doi T., Mandai K., Ishitsuka H.: Circulatin platelet-derived endothelial cell growth factor increases in hepatocellular carcinoma patients. Cancer, 82: 1260-1266, 1997.
25. Senger D.R., Galli S.J., Dvorak A.M., Perruzzi C.A., Harvey V.S., Dvorak H.F.: Tumor cell secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science, 219: 983-985, 1983.
26. Ferrara N., Houck K., Jakeman L., Leung W:. Molecular and biological properties of the vascular endothelial growth factor family and proteins. Endocr. Rev., 13:18-32, 1992.
27. Folkman J.: Clinical applications of research on angiogenesis. N. Engl. J. Med., 333: 1757-1763, 1995.
28. Kim K.J., Li B., Winer J., Armanini M., Gillett N., Phillips H.S., Ferrara N.: Inhibition of vascular endothelial growth factor induced angiogenesis suppression tumor growth in vivo. Nature, 362: 841-844, 1993.
29. Potenns A.J., Westphol H.R., de Waal R.M., Ruiter D.J.: The role of vascular permeability factor and basic fibroblast factor in tumor angiogenesis. Biol. Chem. Hoppe-Seyler., 376: 57-70, 1995.
30. Suzuki K., Hayashi N., Miyamoto Y., Yamamoto M., Ohkawa K., Ito Y., Sasaki Y., Yamaguchi Y., Nakase H., Noda K., Enomoto N., Arai K., Yamada Y., Yochihara H., Tujimura T., Kawano K., Yachikawa K., Kamada T.: Expression of vascular permeability factor/vascular endothelial growth factor in human hepatocelluar carcinoma. Cancer Res., 56:3004-3009, 1996.
31. Rak J.W., Croix B.D.S., Kerbel R.S.: Consequences of angio-genesis for tumor progression, metastasis and cancer therapy. Anti-cancer Drugs, 6: 3-18, 1995.
32. Shweiki D., Itin A., Soffer D., Keshet E., Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-intiated angiogenesis. Nature, 359: 834-845,1992.
33. Gasparini G., Harris A.L.: Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool. J. Clin. Oncol., 13: 765-782, 1995.