Modeling cerebral blood flow and flow heterogeneity from magnetic resonance residue data

Journal of Cerebral Blood Flow and Metabolism

Volumn 19, Issue 6, 1999, Pages 690-699

  Østergaard, Leif ^a   Chesler, David A ^b   Weisskoff, Robert M ^b   Sorensen, A Gregory ^b   Rosen, Bruce R ^b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cerebral blood flow; Flow heterogeneity; Humans; Magnetic resonance imaging; Residue detection; Vascular models

Indexed keywords

ADULT; ARTICLE; BASAL GANGLION; BRAIN BLOOD FLOW; CONTROLLED STUDY; FLOW KINETICS; HUMAN; HUMAN EXPERIMENT; MATHEMATICAL MODEL; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCIPITAL CORTEX; PRIORITY JOURNAL; WHITE MATTER;

EID: 0033509609     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199906000-00013     Document Type: Article

References (25)

1. Abounader R, Vogel J, Kuschinsky W (1995) Patterns of capillary plasma perfusion in brains in conscious rats during normocapnia and hypercapnia. Circ Res 76:120-126
2. Boxerman JL, Hamberg LM, Rosen BR, Weisskoff RM (1995) MR contrast due to intravascular magnetic susceptibility perturbations. Magn Reson Med 34:555-566
3. Chan IS, Goldstein AA, Bassingthwaighte JB (1993) SENSOP: a de rivative-free solver for nonlinear least squares with sensitivity scaling. Ann Biomed Eng 21:621-631
4. Fisel CR, Ackerman JL, Buxton RB, Garrido L, Belliveau JW, Rosen BR, Brady TJ (1991) MR contrast due to microscopically heterogeneous magnetic susceptibility: numerical simulations and applications to cerebral physiology. Magn Reson Med 17:336-347
5. Hudetz AG, Biswal BB, Feher G, Kampine JP (1997) Effects of hypoxia and hypercapnia on capillary flow velocity in the rat cerebral cortex. Microvasc Res 54:35-42
6. King RB, Deussen A, Raymond GM, Bassingthwaighte JB (1993) A vascular transport operator. Am J Physiol 265:H2196-H2208
7. King RB, Raymond GM, Bassingthwaighte JB (1996) Modeling blood flow heterogeneity. Ann Biomed Eng 24:352-372
8. Kroll K, Wilke N, Jerosch HM, Wang Y, Zhang Y, Bache RJ, Bassingthwaighte JB (1996) Modeling regional myocardial flows from residue functions of an intravascular indicator. Am J Physiol 271:H1643-H1655
9. Kwong KK, Belliveau JW, Chesler DA, Goldberg IE, Weisskoff RM, Poncelet BP, Kennedy DN, Hoppel BE, Cohen MS, Turner R, et al (1992) Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci USA 89:5675-5679
10. Kuschinsky W, Paulson, OB (1992) Capillary circulation in the brain. Cerebrovasc Brain Metab Rev 4:261-286
11. Leenders KL, Perani D, Lammertsma AA, Heather JD, Buckingham P, Healy MJ, Gibbs JM, Wise RJ, Hatazawa J, Herold S, et al. (1990) Cerebral blood flow, blood volume and oxygen utilization. Normal values and effect of age. Brain 113:27-47
12. Li Z, Yipintsoi T, Bassingthwaighte JB (1997) Nonlinear model for capillary-tissue oxygen transport and metabolism. Ann Biomed Eng 25:604-619
13. 2O PET in humans. J Cereb Blood Flow Metab 18:935-940
14. Østergaard L, Smith DF, Vestergaard-Poulsen P, Hansen SB, Gee A, Gjedde A, Gyldensted C (1998a) Absolute cerebral blood flow and blood volume measured by MRI bolus tracking: comparison with PET values. J Cereb Blood Flow Metab 18:425-432
15. Østergaard L, Sorensen AG, Kwong KK, Weisskoff RM, Gyldensted C, Rosen BR (1996fc) High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: Experimental comparison and preliminary results. Magn Reson Med 36:726-736
16. Østergaard L, Weisskoff RM, Chesler DA, Gyldensted C, Rosen BR (19966) High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I: Mathematical approach and statistical analysis. Magn Reson Med 36:715-725
17. Porkka L, Neuder M, Hunter G, Weisskoff RM, Belliveau JW, Rosen BR (1991) Arterial Input Function Measurement with MRI. In: Proc Society Magnetic Resonance in Medicine, 10th Annual Meeting, San Francisco, 1991. p 120
18. Rosen BR, Belliveau JW, Aronen HJ, Kennedy D, Buchbinder BR, Fischman A, Gruber M, Glas J, Weisskoff RM, Cohen MS, and others (1991a) Susceptibility contrast imaging of cerebral blood volume: human experience. Magn Reson Med 22:293-299
19. Rosen BR, Belliveau JW, Buchbinder BR, McKinstry RC, Porkka LM, Kennedy DN, Neuder MS, Fisel CR, Aronen HJ, Kwong KK, and others (19916) Contrast agents and cerebral hemodynamics. Magn Reson Med 19:285-292
20. Rosen BR, Belliveau JW, Vevea JM, Brady TJ (1990) Perfusion imaging with NMR contrast agents. Magn Reson Med 14:249-265
21. Stewart GN (1894) Researches on the circulation time in organs and on the influences which affect it. Parts I-III. J Physiol (London) 15:1-45
22. Villringer A, Rosen BR, Belliveau JW, Ackerman JL, Lauffer RB, Buxton RB, Chao YS, Wedeen VJ, Brady TJ (1988) Dynamic imaging with lanthanide chelates in normal brain: contrast due to magnetic susceptibility effects. Magn Reson Med 6:164-174
23. Weisskoff RM, Zuo CS, Boxerman JL, Rosen BR (1994) Microscopic susceptibility variation and transverse relaxation: theory and experiment. Magn Reson Med 31:601-610
24. Wilke N, Kroll K, Merkle H, Wang Y, Ishibashi Y, Xu Y, Zhang J, Jerosch HM, Muhler A, Stillman AE, and others (1995) Regional myocardial blood volume and flow: first-pass MR imaging with polylysine-Gd-DTPA. J Magn Reson Imaging 5:227-237
25. Wong EC, Buxton RB, Frank LR (1997) Implementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin labeling. NMR Biomed 10:237-249