Pathogenesis of Cryptococcus neoformans is associated with quantitative differences in multiple virulence factors

Mycopathologia

Volumn 147, Issue 1, 1999, Pages 1-11

  Blackstock, Rebecca ^b   Buchanan, Kent L ^a   Cherniak, Robert ^c   Mitchell, Thomas G ^c   Wong, Brian ^c   Bartiss, Ann ^c   Jackson, Lydgia ^c   Murphy, Juneann W ^c  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c NONE

Author keywords

Capsule; Cryptococcus; Mannitol; Melanin

Indexed keywords

CULTURE MEDIUM; FUNGAL GENE; FUNGAL GROWTH; FUNGAL INFECTION; GENE EXPRESSION REGULATION; GENETIC DIFFERENCE; GENETIC TRAIT; GROWTH RATE; MANNITOL; MELANIN; MOUSE; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; VIRULENCE;

CHROMATOGRAPHY, GAS; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; DNA FINGERPRINTING; DNA PRIMERS; DNA, FUNGAL; ELECTROPHORESIS, AGAR GEL; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MANNITOL; MELANINS; MONOPHENOL MONOOXYGENASE; POLYMERASE CHAIN REACTION; POLYSACCHARIDES; VIRULENCE;

FILOBASIDIELLA NEOFORMANS;

EID: 0033506968     PISSN: 0301486X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007041401743     Document Type: Article

References (38)

1. Kwon-Chung KJ, Bennett JE. Epidemiologic differences between the two varieties of Cryptococcus neoformans. American Journal of Epidemiology 1984; 120: 123-130.
2. Kwon-Chung KJ, Bennett JE. Cryptococcosis. Medical Mycology. Philadelphia, PA: Lea & Febiger, 1992: 398-399.
3. Blackstock R, Murphy JW. Secretion of the C3 component of complement by peritoneal cells cultured with encapsulated Cryptococcus neoformans. Infection and Immunity 1997; 65: 4114-4121.
4. Curtis JL, Huffnagle GB, Chen GH et al. Differences in pulmonary inflammation and lymphocyte recruitment induced by two encapsulated strains of Cryptococcus neoformans. Laboratory Investigation 1994; 71: 113-126.
5. Blackstock R, Buchanan KL, Adesina AM, Murphy JW. Differential regulation of immune responses by highly and weakly virulent Cryptococcus neoformans isolates. Infection and Immunity 1999; 67: 3601-3609.
6. Turner SH, Cherniak R, Reiss E, Kwon Chung KJ. Structural variability in the glucuronoxylomannan of Cryptococcus neoformans serotype-A isolates determined by C-13 NMR spectroscopy. Carbohydrate Research 1992; 233: 205-218.
7. Buchanan KL, Murphy JW What makes Cryptococcus neoformans a pathogen? Emerging Infectious Diseases 1998; 4: 71-83.
8. Dong ZM, Murphy JW. Intravascular cryptococcal culture filtrate (CneF) and its major component, glucuronoxylomannan, are potent inhibitors of leukocyte accumulation. Infection and Immunity 1995; 63: 770-778.
9. Dong ZM, Murphy JW Cryptococcal polysaccharides induce L-selectin shedding and tumor necrosis factor receptor loss from the surface of human neutrophils. Journal of Clinical Investigation 1996; 97: 689-698.
10. Dong ZM, Jackson L, Murphy JW. Mechanisms for induction of L-selectin loss from T lymphocytes by a cryptococcal polysaccharide, glucuronoxylomannan. Infection and Immunity 1999; 67: 220-229.
11. Murphy JW. Cell-Mediated Immunity. The Mycota Volume VII, Animal and Human Relationships. 1996: 67-97.
12. Rhodes JC, Polacheck I, Kwon-Chung KJ. Phenoloxidase activity and virulence in isogenic strains of Cryptococcus neoformans. Infection and Immunity 1982; 36: 1175-1184.
13. Wang Y, Aisen P, Casadevall A. Cryptococcus neoformans melanin and virulence: mechanism of action. Infection and Immunity 1995; 63: 3131-3136.
14. Huffnagle GB, Stricter RM, NcNeil LS, McDonald RA, Burdick MD, Toews GB. The role of TNF and melanin in modulating the development of protective T cell mediated immunity in the lungs to C. neoformans. Proceedings of the 3rd International Conference on Cryptococcus and Cryptococcosis 1996; 164.
15. Chaturvedi V, Wong B, Newman SL. Oxidative killing of Cryptococcus neoformans by human neutrophils. Evidence that fungal mannitol protects by scavenging reactive oxygen intermediates. The Journal of Immunology 1996; 156: 3836-3840.
16. Wong B, Perfect JR, Beggs S, Wright KA. Production of the hexitol D-mannitol by Cryptococcus neoformans in vitro and in rabbits with experimental meningitis. Infection and Immunity 1990; 58: 1664-1670.
17. Growth of Bacteria. Sokatch JR, Ferretti JJ. Basic Bacteriology and Genetics. Chicago: Year Book Medical Publishers, 1976: 36-54.
18. Moore TD, Edman JC. The alpha-mating type locus of Cryptococcus neoformans contains a peptide phermone gene. Molecular and Cellular Biology 1993; 13: 1962-1970.
19. Meyer W, Mitchell TG. Polymerase chain reaction fingerprinting in fungi using single primers specific to minisatellites and simple repetitive DNA sequences: strain variation in Cryptococcus neoformans. Electrophoresis 1995; 16(9): 1648-1656.
20. 13C nuclear magnetic resonance spectroscopy. Infection and Immunity 1998; 66: 2996-2998.
21. Cherniak R, Valafar H, Morris LC, Valafar F. Cryptococcus neoformans chemotyping by quantitative analysis of 1H nuclear magnetic resonance spectra of glucuronoxylomannans with a computer-simulated artificial neural network. Clinical and Diagnostic Laboratory Immunology 1998; 5: 146-159.
22. Cherniak R, Morris LC, Meyer SA. Glucuronoxylomannan of Cryptococcus neoformans serotype-C - Structural analysis by gas liquid chromatography mass spectrometry and C-13-nuclear magnetic resonance spectroscopy. Carbohydrate Research 1992; 225: 331-337.
23. Rhodes JC. A simplified assay for cryptococcal phenoloxidase. Mycologia 1986; 78: 867-868.
24. Wong B, Brauer L, Tsai RR, Jayasimhulu K. Increased amounts of the Aspergillus metabolite D-mannitol in tissues and serum of animals with experimental aspergillosis. Journal of Infectious Diseases 1989; 160: 95-103.
25. Kwon-Chung KJ, Edman JC, Wickes BL. Genetic association of mating types and virulence in Cryptococcus neoformans. Infection and Immunity 1992; 60: 602-605.
26. Fries BC, Casadevall A. Serial isolates of Cryptococcus neoformans from patients with AIDS differ in virulence for mice. Journal of Infectious Diseases 1998; 178: 1761-1766.
27. Huffnagle GB, Chen G-H, Curtis JL, McDonald RA, Strieter RM, Toews GB. Down-regulation of the afferent phase of T cell-mediated pulmonary inflammation and immunity by a high melanin-producing strain of Cryptococcus neoformans. Journal of Immunology 1995; 155: 3507-3516.
28. Liu L, Tewari RP, Williamson PR. Laccase protects Cryptococcus neoformans from antifungal activity of alveolar macrophages. Infection and Immunity 1999; 67: 6034-6039.
29. Vartivarian SE, Anaissie EJ, Cowart RE, Sprigg HA, Tingler MJ, Jacobson ES. Regulation of cryptococcal capsular polysaccharide by iron. Journal of Infectious Diseases 1993; 167: 186-190.
30. Granger DL, Perfect JR, Durack DT. Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide. Journal of Clinical Investigation 1985; 76: 508-516.
31. Nurudeen TA, Ahearn DG. Regulation of melanin production by Cryptococcus neoformans. Journal of Clinical Microbiology 1979; 10: 724-729.
32. Polacheck I, Hearing VJ, Kwon-Chung KJ. Biochemical studies of phenoloxidase and utilization of catecholamines in Cryptococcus neoformans. Journal of Bacteriology 1982; 150: 1212-1220.
33. Williamson PR. Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: identification as a laccase. Journal of Bacteriology 1994; 176: 656-664.
34. Kwon-Chung KJ. Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans. Mycologia 1976; 68: 942-946.
35. Wickes BL, Mayorga ME, Edman U, Edman JC. Dimorphism and hapliod fruiting in Cryptococcus neoformans: Association with the α-mating type. Proceedings of the National Academy of Sciences USA 1996; 93: 7327-7331.
36. Alspaugh JA, Perfect JR, Heitman J. Cryptococcus neoformans mating and virulence are regulated by the G-protein a subunit GPA1 and cAMP. Genes and Development 1997; 11: 3206-3217.
37. Lorenz MD, Heitman J. Yeast pseudohyphal growth is regulated by GPA2, a G protein a homolog. EMBO Journal 1997; 16: 7008-7018.
38. Chaturvedi V, Flynn T, Niehaus T, Wong B. Stress tolerance and pathogenic potential of a mannitol mutant of Cryptococcus neoformans. Microbiology 1996; 142: 937-943.