The benefits of topical vitamin C (L-ascorbic acid) for skin care and UV protection

Journal of Applied Cosmetology

Volumn 17, Issue 4, 2000, Pages 126-134

  Pinnell, Sheldon R ^a   Madey, Doren L ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antioxidants; Ascorbyl palmitate; L ascorbic acid; Magnesium ascorbyl phosphate; Photoprotection; Ultraviolet radiation; UV immunosuppression; Vitamin C

Indexed keywords

ASCORBIC ACID; ASCORBYL PALMITATE;

ANTIOXIDANT ACTIVITY; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG STABILITY; DRUG STRUCTURE; ERYTHEMA; LIGHT DAMAGE; SKIN ABSORPTION; SKIN CANCER; SKIN CARE; SUNLIGHT PROTECTION; ULTRAVIOLET A RADIATION; WOUND HEALING;

EID: 0033496012     PISSN: 03928543     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Darr, D. and Pinnell, S. R. Stable Ascorbic Acid Compositions. Duke University Medical Center, Durham NC. 339,488(5,140,043), 1-8. 1992. USA. 1989. (GENERIC) Ref Type: Patent
2. Levine M, Conry-Cantilena C, Wang Y, Welch RW, et al Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowance. Proc.Natl.Acad.Sci.USA 1996; 93: 3704-3709.
3. Colven RM, Pinnell SR Topical vitamin C in aging. [Review] [58 refs]. Clin.Dermatol 1996; 14: 227-234.
4. Halpner AD, Handelman GJ, Harris JM, Belmont CA, et al Protection by vitamin C of loss of vitamin E in cultured rat hepatocytes. Arch.Biochem.Biophys. 1998; 359: 305-309.
5. Darr D, Combs S, Dunston S, Manning T, et al Topical vitamin C protects porcine skin from ultraviolet radiation-induced damage. Br.J Dermatol 1992; 127: 247-253.
6. Kadunce DP, Burr R, Gress.R., Kanner R, et al Cigarette smoking: risk factor for premature facial wrinkling. Ann Internal Med 1991; 114: 840-844.
7. Kameyama K, Sakai C, Kondoh S, Yonemoto K, et al Inhibitory effect of magnesium L-ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo. J.Am.Acad.Dermatol. 1996; 34: 29-33.
8. Hata R-I, Senoo H L-Ascorbic Acid 2-Phosphate Stimulates Collagen Accumulation, Cell Proliferation, and Formation of a Three-Dimensional Tissuelike Substance by Skin Fibroblasts. J of Cellular Phys 1989; 138: 8-16.
9. Perricone NV Topical Vitamin C Ester (Ascorbyl Palmitate. J of Geriatric Derm 1997; 5: 162-170.
10. Bissett DL, Chatterjee R, Hannon DP Photoproective effect of superoxide-scavenging antioxidants against ultraviolet radiation-induced chronic skin damage in the hairless mous. Photodermatol.Photoimmunol.Photomed. 1990; 7: 56-62.
11. Tyrrell RM Oxidant, antioxidant status and photocarcinogenesis: the role of gene activation. [Review] [31 refs]. Photochem.Photobiol. 1996; 63: 380-386.
12. Black HS, deGruijl FR, Forbes PD, Cleaver JE Photocarcinogenesis: an overview. Photochem.Photobiol. 1997; 40: 29-47.
13. Drobetsky EA, Turcotte J, Chateauneuf A A role for ultraviolet A in solar mutagenesis. Proc.Natl.Acad.Sci.U.S.A. 1995; 92: 2350-2354.
14. Kielbassa C, Roza L, Epe B Wavelength dependence of oxidative DNA damage induced by UV and visible light. Carcinogenesis 1997; 18: 811-816.
15. Stary A, Robert C, Sarasin A Deleterious effects of ultraviolet A radiation in human cells. [Review] [50 refs]. Mutat.Res. 1997; 383: 1-8.
16. de Laat JM, de Gruijl FR The Role of UVA in the Aetiology of Non-melanoma Skin Cancer. Cancer Surveys 1996; 26: 173-191.
17. Lavker RM, Kaidbey KH A Rationale for the Development and Use of Sunscreens That Protect from Ultraviolet B and Total Ultraviolet A Radiation. JGD: Clinical Topics on the Skin of the Aging and Aged 1997; 5: 204-208.
18. Lavker RM, Gerberick GF, Veres D, Irwin CJ, et al Cumulative effects from repeated exposures to suberythemal doses of UVB and UVA in human skin. J.Am.Acad.Dermatol. 1995; 53-62.
19. Lowe NJ, Meyers DP, Wieder JM, Luftman D, et al Low Doses of Repetitive Ultraviolet A Induce Morphologic Changes in Human Skin. J.Invest.Dermatol. 1995; 739-743.
20. Lavker RM, Veres DA, Irwin CJ, Kaidbey KH Quantitative Assessment of Cumulative Damage From Repetitive Exposures to Suberythemogenic Doses of UVA In Human Skin. Photochem.Photobiol. 1995; 62: 348-352.
21. Hanson K, Simon J Epidermal trans-urocanic acid and the UV-A-induced photoaging of the skin. Proc.Natl.Acad.Sci.USA. 1998; 95: 10576-10578.
22. Bissett DL, Hannon DP, Orr TV Wavelength Dependence of Histological, Physical, and Visible Changes in Chronically UV-Irradiated Hairless Mouse Skin. Photochem.Photobiol. 1989; 50: 763-769.
23. Scharffetter K, Wlaschek M, Hogg A, Bolsen K, et al UVA irraiation induces collagenase in human dermal fibroblasts in vitro and in vivo. Arch.Dermatol.Res. 1991; 506-511.
24. Wlaschek M, Wenk J, Brenneisen P, Briviba K, et al Singlet oxygen is an early intermediate in cytokine-dependent ultraviolet-A induction of interstitial collagenase in human dermal fibroblasts in vitro. FEBS 1997; 239-242.
25. Fisher GJ, Wang ZQ, Datta SC, Varani J, et al Pathophysiology of premature skin aging induced by ultraviolet light. N.Engl.J.Med. 1997; 337: 1419-1429.
26. Autier P, Dore JF, Schifflers E, Cesarini JP, et al Melanoma and use of sunscreens: an Eortc case-control study in Germany, Belgium and France. The EORTC Melanoma Cooperative Group. Int.J.Cancer 1995; 61: 749-755.
27. Stern RS, Nichols KT, Vakeva LH Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). The PUVA Follow-Up Study [see comments]. N.Engl.J Med. 1997; 1041-1045.
28. Setlow RB, Woodhead AD Temporal changes in the incidence of malignant melanoma: explanation from action spectra. Mutat.Res. 1994; 307: 365-374.
29. Husain Z, Pathak MA, Flotte T, Wick MM Role of Ultraviolet Radiation in the Induction of Melanocytic Tumors in Hairless Mice following 7.12-Dimethylbenz(a)anthracene Application and Ultraviolet Irradiation. Can.Res. 1991; 4964-4970.
30. LeVee GJ, Oberhelman L, Anderson T, Koren H, et al UVA II exposure of human skin results in decreased immunization capacity, increased induction of tolerance and a unique pattern of epidermal antigen-presenting cell alteration. Photochem.Photobiol. 1997; 65: 622-629.
31. Clement-Lacroix P, Michel L, Moysan A, Morliere P, et al UVA-induced immune suppression in human skin: protective effect of vitamin E in human epidermal cells in vitro. Br.J Dermatol 1996; 134: 77-84.
32. Streilein JW, Taylor JR, Vincek V, Kurimoto I, et al Immune surveillance and sunlight-induced skin cancer. [Review] [53 refs]. Immunol.Today 1994; 15: 174-179.
33. Nakamura T, Pinnell SR, Darr D, Kurimoto I, et al Vitamin C. Abrogates, the Deleterious Effects of UVB Radiation on Cutaneous Immunity by a Mechanism That does Not Depend on TNF-a. J.Invest.Dermatol. 1997; 20-24.
34. Helbock HJ, Beckman KB, Shigenaga MK, Walter PB, et al DAN oxidation matters: The HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine. Proc.Natl.Acad.Sci.U.S.A. 1998; 228-293.
35. Stewart MS, Cameron GS, Pence BC Antioxidant nutrients protect against UVB-induced oxidative damage to DNA of mouse keratinocytes in culture. J Invest.Dermatol 1996; 106: 1086-1089.
36. Pinnell, S. R. and Bergfeld, W. Topical Vitamin C. Pinnell, S. R. and Bergfeld, W. 4-1996. Dialogues in Dermatology 38(1). (GENERIC) Ref Type: Sound Recording
37. Alster T, West TB Effect of Topical Vitamin C on Postoperative Carbon Dioxide Laser Resurfacing Erythema. Dermatol Surg 1998; 331-334.
38. Ash K, Lord J, Zukowski M, McDaniel DH Comparison of Topical Therapy for Striae Alba (20% Glycolic Acid/0.5% Tretinoin Versus 20% Glycolic Acid/10% L-Ascorbic Acid). Dermatol Surg 1998; 24: 849-856.
39. Murad S, Grove D, Lindberg KA, Reynolds G, et al Regulation of collagen synthesis by ascorbic acid. Proc.Natl.Acad.Sci.U.S.A. 1981; 78: 2879-2882.
40. Kivirikko KI, Myllyla R Post-translational processing of procollagens. Ann.N.Y.Acad.Sci. 1985; 460: 187-201.
41. Tajima S, Pinnell SR Ascorbic acid preferentially enhances type I and III collagen gene transcription in human skin fibroblasts. J Dermatol Sci. 1996; 11: 250-253.