Altered molecular architecture of peripheral nerves in mice lacking the peripheral myelin protein 22 or connexin32

Journal of Neuroscience Research

Volumn 58, Issue 5, 1999, Pages 612-623

  Neuberg, Dirk H H ^a   Sancho, Sara ^a   Suter, Ueli ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Axon glia interactions; Demyelination; Peripheral neuropathies; Potassium channel; Transgenic mice

Indexed keywords

CONNEXIN 32; MYELIN ASSOCIATED GLYCOPROTEIN; MYELIN BASIC PROTEIN; MYELIN PROTEIN; POTASSIUM CHANNEL; UVOMORULIN;

ANIMAL TISSUE; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; DEMYELINATION; FEMALE; GLIA; MALE; MOUSE; MOUSE MUTANT; NERVE FIBER; NERVE FIBER DEGENERATION; NONHUMAN; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TRANSGENIC MOUSE;

ANIMALS; CADHERINS; CONNEXINS; FEMALE; GENOTYPE; HEREDITARY MOTOR AND SENSORY NEUROPATHIES; IMMUNOHISTOCHEMISTRY; KV1.1 POTASSIUM CHANNEL; MALE; MICE; MICE, KNOCKOUT; MUTATION; MYELIN BASIC PROTEINS; MYELIN PROTEINS; MYELIN SHEATH; MYELIN-ASSOCIATED GLYCOPROTEIN; PERIPHERAL NERVES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; TIME FACTORS;

EID: 0033485879     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19991201)58:5<612::AID-JNR2>3.0.CO;2-X     Document Type: Article

References (65)

1. Adlkofer K, Martini R, Aguzzi A, Zielasek J Toyka KV, Suter U. 1995. Hypermyelination and demyelinating peripheral neuropathy in PMP22-deficient mice. Nat Genet 11:274-280.
2. Adlkofer K, Frei R, Neuberg DH-H, Zielasek J, Toyka KV, Suter U. 1997. Heterozygous peripheral myelin protein 22-deficient mice are affected by a progressive demyelinating tomaculous neuropathy. J Neurosci 17:4662-4671.
3. Anzini P, Neuberg DH-H, Schachner M, Nelles E, Willecke K, Zielasek J, Toyka KV, Suter U, Martini R. 1997. Structural abnormalities and deficient maintenance of peripheral nerve myelin in mice lacking the gap junction protein Connexin32. J Neurosci 17:4545-4551.
4. Balice-Gordon RJ, Bone LJ, Scherer SS. 1998. Functional gap junctions in the Schwann cell myelin sheath. J Cell Biol 142:1095-1104.
5. Brancolini C, Marzinotto S, Edomi P. Agostini E, Fiorentini C, Mueller HW, Scheider C. 1999. Rho-dependent regulation of cell spreading by the tetraspan membrane protein Gas3/PMP22. Mol Biol Cell 10:2441-2451.
6. Chiu SY, Ritchie JM. 1980. Potassium channels in nodal and internodal axonal membrane of mammalian myelinated fibres. Nature 284:170-171.
7. Chiu SY, Ritchie JM, Rogart RB, Stagg D. 1979. A quantitative description of membrane currents in rabbit myelinated nerve. J Physiol 292:149-166.
8. Ciutat D, Caldero J, Oppenheim RW, Esquerda JE. 1996. Schwann cell apoptosis during normal development and after axonal degeneration induced by neurotoxins in the chick embryo. J Neurosci 16:3979-3990.
9. Deerinck TJ, Levinson SR, Bennett GV, Ellisman MH. 1997. Clustering of voltage-sensitive sodium channels on axons is independent of direct Schwann cell contact in the dystrophic mouse. J Neurosci 17:5080-5088.
10. Dong Z, Brennan A, Liu N, Yarden Y, Lefkowitz G, Mirsky R, Jessen KR. 1995. Neu differentiation factor is a neuron-glia signal and regulates survival proliferation and maturation of rat Schwann cell precursors. Neuron 15:585-596.
11. Dugandzija-Novakovic S, Koszowski AG, Levinson SR, Shrager P. 1995. Clustering of Na+ channels and node of Ranvier formation in remyelinating axons. J Neurosci 15:492-503.
12. Ellisman MH. 1979. Molecular specializations of the axon membrane at nodes of Ranvier are not dependent upon myelination. J Neurocytol 8:719-735.
13. Fabbretti E, Edomi P, Brancolini C, Schneider C. 1995. Apoptotic phenotype induced by overexpression of wild-type gas3/ PMP22: its relation to the demyelinating peripheral neuropathy CMT 1A. Genes Dev 9:1846-1856.
14. Fannon AM, Sherman DL, Ilyina-Gragerova, G, Brophy PJ, Friedrich VL Jr, Colman DR. 1995. Novel E-cadherin-mediated adhesion in peripheral nerve: Schwann cell architecture is stabilized by autotypic adherens junctions. J Cell Biol 129:189-202.
15. Friede RL, Samorajski T. 1967. Relation between the number of myelin lamellae and axon circumference. J Comp Neurol 130:223-231.
16. Fruttiger M, Montag D, Schachner M, Martini R. 1995. Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity. Eur J Neurosci 7:511-515.
17. Grinspan JB, Marchionni MA, Reeves M, Coulaloglou M, Scherer SS. 1996. Axonal interactions regulate Schwann cell apoptosis in developing periheral nerve: neuregulin receptors and the role of neuregulins. J Neurosci 16:6107-6118.
18. Hallows JL, Tempel BL. 1998. Expression of Kv11 a Shaker-like potassium channel is temporally regulated in embryonic neurons and glia. J Neurosci 18:5682-5691.
19. Hildebrand C, Remahl S, Persson H, Bjartmar C. 1993. Myelinated nerve fibres in the CNS. Prog Neurobiol 40:319-384.
20. Johnston WL, Dyer JR, Castellucci VF, Dunn RJ. 1996. Clustered voltage-gated Na+ channels in Aplysia axons. J Neurosci 16:1730-1739.
21. Kaplan MR, Meyer-Franke A, Lambert S, Bennett V, Duncan ID, Levinson SR, Barres BA. 1997. Induction of sodium clustering by oligodendrocytes. Nature 386:724-728.
22. Li C, Tropak MB, Gerlai R, Clapoff S, Abramow-Newerly W, Trapp B, Peterson A, Roder J. 1994. Myelination in the absence of myelin-associated glycoprotein. Nature 369:747-750.
23. Martini R, Mohajeri MH, Kasper S, Giese KP, Schachner M. 1995. Mice doubly deficient in the genes for PO and myelin basic protein show that both proteins contribute to the formation of the major dense line in peripheral nerve myelin. J Neurosci 15:4488-4495.
24. Martini R, Schachner M. 1986. Immunoelectron microscopic localization of neural cell adhesion molecules (L1 N-CAM and MAG) and their shared carbohydrate epitope and myelin basic protein in developing sciatic nerve. J Cell Biol 103:2439-2448.
25. Martini R, Schachner M. 1997. Molecular bases of myelin formation as revealed by investigations on mice deficient in glial cell surface molecules. Glia 19:298-310.
26. Mi H, Deerinck TJ, Ellisman MH, Schwarz TL. 1995. Differential distribution of closely related potassium channels in rat. J Neurosci 15:3761-3774.
27. Montag D, Giese KP, Bartsch U. Martini R, Lang Y, Bluthmann H, Karthigasan J, Kirschner DA, Wintergerst ES, Nave KA, Schachner M. 1994. Mice deficient for the myelin-associated glycoprotein show subtle abnormalies in myelin. Neuron 13:229-246.
28. Naef R, Suter U. 1998. Many facets of the peripheral myelin protein PMP22 in myelination and disease. Microsc Res Tech 41:359-371.
29. Naef R, Adlkofer K, Lescher B. Suter U. 1997. Aberrant protein trafficking in Trembler suggests a disease mechanism for hereditary human peripheral neuropathies. Mol Cell Neurosci 9:13-25.
30. Nelles E, Bützler C, Jung D, Temme A, Gabriel H-D, Dahl U, Traub O, Stümpel F, Jungermann K, Zielasek J, Toyka KV, Dermietzel R, Willecke K. 1996. Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32 deficient mice. Proc Natl Acad Sci 93:9565-9570.
31. Neuberg DH, Carenini S, Schachner M, Martini R, Suter U. 1998. Accelerated demyelination of peripheral nerves in mice deficient in connexin 32 and protein zero. J Neurosci Res 53:542-550.
32. Novakovic SD, Deerinck TJ, Levinson SR, Shrager P, Ellisman MH. 1996. Clusters of axonal Na+ channels adjacent to remyelinating Schwann cells. J Neurocytol 25:403-412.
33. Paul DL. 1995. New functions for gap junctions. Curr Opin Cell Biol 7:665-672.
34. Rasband MN, Trimmer JS, Schwarz TL. Levinson SR, Ellisman MH, Schachner M, Shrager P. 1998. Potassium channel distribution clustering and function in remyelinating rat axons. J Neurosci 18:36-47.
35. Rosenbluth J. 1976. Intramembranous particle distribution at the node of Ranvier and adjacent axolemma in myelinated axons of the frog brain. J Neurocytol 5:731-745.
36. Rosenbluth J. 1979. Aberrant axon-Schwann cell junctions in dystrophic mouse nerves. J Neurocytol 8:655-672.
37. Sancho S, Magyar JP, Aguzzi A, Suter U. 1999. Distal axonopathy in peripheral nerves of PMP22 mutant mice. Brain 122:1563-1577.
38. Scherer SS. 1996. Molecular specializations at nodes and paranodes in peripheral nerve. Microsc Res Tech 34:452-461.
39. Scherer SS, Xu YT, Nelles E, Fischbeck K, Willecke K, Bone LJ. 1998. Connexin32-null mice develop demyelinating peripheral neuropathy. Glia 24:8-20.
40. Shapiro P, Doyle JP, Hensley P, Colman DR, Hendrickson WA. 1996. Crystal structure of the extracellular domain PO, the major structural protein of peripheral nerve myelin. Neuron 17:435-449.
41. Smart SL, Lopantsev V, Zhang CL, Robbins CA, Wang H, Chiu SY, Schwartzkroin PA, Messing A, Tempel BL. 1998. Deletion of the K(V)11 potassium channel causes epilepsy in mice. Neuron 20:809-819.
42. Snipes GJ, Suter U. 1995. Molecular basis of common hereditary motor and sensory neuropathies in human and in mouse models. Brain Pathol 5:233-247.
43. Sommer L, Suter U. 1998. The glycoprotein PO in peripheral gliogenesis. Cell Tissue Res 292:11-16.
44. Suter U. 1999. Charcot-Marie-Tooth Disease: pathology, genetics, and animal models. In: Popko B, editor. Mouse models in the study of genetic neurological disorders. Advances in neurochemistry, vol. 9. New York: Kluwer Academic/Plenum Press, p 43-61.
45. Suter U, Snipes GJ. 1995. Biology and genetics of hereditary motor and sensory neuropathies. Annu Rev Neurosci 18:45-75.
46. Suter U, Welcher AA, Ozcelik T, Snipes GJ, Kosaras B, Francke U, Billings-Gagliardi S, Sidman RL. Shooter EM. 1992. Trembler mouse carries a point mutation in a myelin gene. Nature 356:241-244.
47. Syroid DE, Maycox PR, Burrola PG, Liu N, Wen D, Lee KF, Lemke G, Kilpatrick TJ. 1996. Cell death in the Schwann cell lineage and its regulation by neuregulin. Proc Natl Acad Sci USA 93:9229-9234.
48. Syroid DE, Zorick TS, Arbet-Engels C, Kilpatrick TJ, Eckhart W, Lemke G. 1999. A role for insulin-like growth factor-I in the regulation of Schwann cell survival. J Neurosci 19:2059-2068.
49. Toyka KV, Zielasek J, Ricker K, Adlkofer K, SuterU. 1997. Hereditary neuromyotonia: a mouse model associated with deficiency or increased gene dosage of the PMP22 gene. J Neurol Neurosurg Psychiatry 63:812-813.
50. Trachtenberg JT, Thompson WJ. 1996. Schwann cell apoptosis at developing neuromuscular junctions is regulated by glial growth factor. Nature 379:174-177.
51. Trapp BD, Quarles RH, Griffin JW. 1984. Myelin-associated glycoprotein and myelinating Schwann cell-axon interaction in chronic BB'-iminodipropionitrile neuropathy. J Cell Biol 98:1272-1278.
52. Trapp BD, Andrews SB, Wong A, O'Connell M, Griffin JW. 1989. Co-localization of the myelin-associated glycoprotein and the microfilament components F-actin and spectrin in Schwann cells of myelinated nerve fibres. J Neurocytol 18:47-60.
53. Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mork S, Bo L. 1998. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 338:278-285.
54. Umemori H, Sato S, Yagi T, Aizawa S, Yamamoto T. 1994. Initial events of myelination involve Fyn tyrosine kinase signalling. Nature 367:572-576.
55. Vabnick I, Novakovic SD, Levinson SR, Schachner M, Shrager P. 1996. The clustering of axonal sodium channels during development of the peripheral nervous system. J Neurosci 16:4914-4922.
56. Vabnick I, Messing A, Chiu SY, Levinson SR, Schachner M, Roder J, Li C, Novakovic S, Shrager P. 1997. Sodium channel distribution in axons of hypomyelinated and MAG null mutant mice. J Neurosci Res 50:321-336.
57. Vabnick I, Trimmer JS, Schwarz TL, Levinson SR, Risal D, Shrager P. 1999. Dynamic potassium channel distributions during axonal development prevent aberrant firing patterns. J Neurosci 19:747-758.
58. Vestweber D, Kemler R. 1985. Identification of a putative cell adhesion domain of uvomorulin. EMBO J 4:3393-3398.
59. Wang H, Allen ML, Grigg JJ, Noebels JL, Tempel BL. 1995. Hypomyelination alters K+ channel expression in mouse mutants shiverer and Trembler. Neuron 15:1337-1347.
60. Wiley-Livingston C, Ellisman MH. 1980. Development of axonal membrane specializations defines nodes of Ranvier. Dev Biol 79:334-355.
61. Williams PL, Wendell-Smith CP. 1971. Some additional parametric variations between peripheral nerve fibres. J nat 109:505-526.
62. Yin X, Crawford TO, Griffin JW, Tu P, Lee VM, Li C, Roder J, Trapp BD. 1998. Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons. J Neurosci 18:1953-1962.
63. Zerr P, Adelman JP, Maylie J. 1998. Episodic ataxia mutations in Kv11 alter potassium channel function by dominant negative effects or haploinsufficiency. J Neurosci 18:2842-2848.
64. Zhou L, Zhang CL, Messing A, Chiu SY. 1998. Temperature-sensitive neuromuscular transmission in Kv1.1 null mice: Role of potassium channels under the myelin sheath in young nerves. J Neurosci 18:7200-7215.
65. Zoidl G, Blass-Kampmann S, D'Urso D, Schmalenbach C, Muller HW. 1995. Retroviral-mediated gene transfer of the peripheral myelin protein PMP22 in Schwann cells: modulation of cell growth. EMBO J 14:1122-1128.