A role for a melanosome transport signal in accessing the MHC class II presentation pathway and in eliciting CD4+ T cell responses

Journal of Immunology

Volumn 163, Issue 11, 1999, Pages 5820-5826

  Wang, Siqun ^a   Bartido, Shirley ^a   Yang, George ^a   Qin, Jie ^a   Moroi, Yoichi ^a   Panageas, Katherine S ^a   Lewis, Jonathan J ^a   Houghton, Alan N ^a,b  

^a Weill Cornell Medical Center   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; COMPLEMENTARY DNA; HYBRID PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MEMBRANE PROTEIN; OVALBUMIN;

ANIMAL CELL; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; ENDOCYTOSIS; HELPER CELL; IMMUNIZATION; INTERNALIZATION; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MELANOMA; MELANOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGEN PRESENTATION; BIOLOGICAL TRANSPORT; CANCER VACCINES; CD4-POSITIVE T-LYMPHOCYTES; ENDOCYTOSIS; FEMALE; GLYCOPROTEINS; HISTOCOMPATIBILITY ANTIGENS CLASS II; MELANOMA, EXPERIMENTAL; MELANOSOMES; MICE; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; VACCINATION; VACCINES, DNA;

EID: 0033485659     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Houghton, A. N. 1994. Cancer antigens: immune recognition of self and altered self. J. Exp. Med. 180:1.
2. Houghton, A. N., M. Eisinger, A. P. Albino, J. G. Cairncross, and L. J. Old. 1982. Surface antigens of melanocytes and melanomas: markers of melanocyte differentiation and melanoma subsets. J. Exp. Med. 156:1755.
3. Diment, S., M. Eidelman, G. M. Rodriguez, and S. J. Orlow. 1995. Lysosomal hydrolases are present in melanosomes and are elevated in melanizing cells. J. Biol. Chem. 270:4213.
4. Vijayasaradni, S., Y. Xu, B. Bouchard, and A. N. Houghton. 1995. Intracellular sorting and targeting of melanosomal membrane proteins: identification of signals for sorting of the human brown locus protein, gp75. J. Cell Biol 130:807.
5. Hearing, V. J., and K. Tsukamoto. 1997. Enzymatic control of pigmentation in mammals. FASEB J. 5:2902.
6. Vijayasaradhi, S., B. Bouchard, and A. N. Houghton. 1990. The melanoma antigen gp75 is the human homologue of the mouse b (brown) locus gene product. J. Exp. Med. 171:1375.
7. Brichard, V., A. Van Pel, T. Wolfel, E. Wolfel, E. De Plaen, B. Lethe, P. Coulie, and T. Boon. 1993. The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J. Exp. Med. 178: 489.
8. Song, Y.-H., E. Connor, Y. Li, B. Zorovich, P. Balducci, and N. Maclaren. 1994. The role of tyrosinase in autoimmune vitiligo. Lancet 344:1049.
9. + T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes. J. Exp. Med. 183: 1965.
10. + T cell clones from the peripheral blood of melanoma patients following in vitro stimulation with recombinant vaccinia virus. J. Immunol. 157:4079.
11. + T cells from peripheral blood of a melanoma patient recognize peptides derived from nonmutated tyrosinase. Cancer Res. 58:296.
12. Houghton, A. N., T. M. Thomson, D. Gross, H. F. Oettgen, and L. J. Old. 1984. Surface antigens of melanoma and melanocytes: specificity of induction of la antigens by human γ-interferon. J. Exp. Med. 160:255.
13. Albino, A. P., Sozzi, G., Nanus, D. M., Jhanwar, S. C., Houghton, A. N. 1992. Malignant transformation of human melanocytes: induction of a complete melanoma phenotype and genotype. Oncogene 7:2315.
14. Xu, Y., S. Vijayasaradhi, and A. N. Houghton. 1998. The cytoplasmic tail of the mouse brown locus product determines intracellular stability and export from the endoplasmic reticulum. J. Invest. Dermatol. 110:324.
15. Fidler, I. J. 1973. Selection of successive tumour lines for metastasis. Nat. New Biol. 242:148.
16. Hara, I., Y. Takechi, and A. N. Houghton. 1995. Implicating a role for immune recognition of self in tumor rejection: passive immunization against the brown locus protein. J. Exp. Med. 182:1609.
17. Falo, L. D., Jr., M. Kovacsovics-Bankowski, K. Thompson, and K. L. Rock. 1995. Targeting antigen into the phagocytic pathway in vivo induces protective tumour immunity. Nat. Med. 1:649.
18. Ross, H. M., L. W. Weber, S. Wang, G. Piskun, R. Dyall, P. Song, Y. Takechi, J. Nikolic-Zugic, A. N. Houghton, and J .J. Lewis. 1997. Priming for T-cell mediated rejection of established tumors by cutaneous DNA immunization. Clin. Cancer Res. 3:2191.
19. Falkner, F. G., S. Chakrabarti, and B. Moss. 1987. pUV I: a new vaccinia virus insertion and expression vector. Nucleic Acids Res. 15:7191.
20. Elroy-Stein, O., and B. Moss. 1994. Expression of proteins in mammalian cells using vaccinia viral vectors. In Current Protocols in Molecular Biology. F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Strahl, eds. Jon Wiley & Sons, New York, p. 16.15.1.
21. Calvo, P. A., D. W. Frank, B. M. Bieler, J. F. Berson, and M. S. Marks. 1999. A cytoplasmic sequence in human tyrosinase defines a second class of di-leucine-based sorting signals for late endosomal and lysosomal delivery. J. Biol. Chem. 274:12780.
22. Sanderson, S., K. Frauwith, and N. Shastri. 1995. Expression of endogenous peptide-major histocompatibility complex class II complexes derived from invariant chain-antigen fusion proteins. Proc. Natl. Acad. Sci. USA 92:7217.
23. Wu, T. C., F. G. Guarnieri, K. F. Staveley-O'Carroll, R. P. Viscidi, H. I. Levitsky, L. Hedrick, K. R. Cho, J. T. August, and D. M. Pardoll. 1995. Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens. Proc. Natl. Acad. Sci. USA 92:11671.