Cholinergic contraction is altered in nNOS knockouts: Cooperative modulation of neural bronchoconstriction by nNOS and COX

American Journal of Respiratory and Critical Care Medicine

Volumn 160, Issue 6, 1999, Pages 2072-2078

  Kakuyama, Masahiro ^a,b   Ahluwalia, Amrita ^a,b   Rodrigo, Jose ^a,b   Vallance, Patrick ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b INSTITUTO CAJAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CARBACHOL; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ARTICLE; BRONCHODILATATION; BRONCHOSPASM; BRONCHUS TONE; CHOLINERGIC STIMULATION; CONTROLLED STUDY; ELECTROSTIMULATION; KNOCKOUT MOUSE; LOWER RESPIRATORY TRACT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION;

EID: 0033454116     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.160.6.9808105     Document Type: Article

References (34)

1. Barnes, P. J. 1995. Nitric oxide and airway disease. Ann. Med. 27:389-393.
2. Figni, M., L. M. Ricciardolo, P. Javdan, F. P. Nijkamp, C. Emanueli, P. Pradelles, G. Folkerts, and P. Geppetti. 1996. Evidence that epithelium-derived relaxing factor released by bradykinin in the guinea-pig trachea is nitric oxide. Am. J. Respir. Crit. Care Med. 153:918-923.
3. Asano, K., C. B. E. Chee, B. Gaston, C. M. Lilly, C. Gerard, J. M. Drazen, and J. S. Stamler. 1994. Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 91:10089-10093.
4. Loêsch, A., and G. Burnstock. 1996. Ultrastructural study of perivascular nerve fibres and endothelial cells of the rat basilar artery immunolabelled with monoclonal antibodies to neuronal and endothelial nitric oxide synthase. J. Neurocytol. 25:525-534.
5. Belvisi, M. G., D. Stretton, and P. J. Barnes. 1992. Nitric oxide as an endogenous modulator of cholinergic neurotransmission in guinea-pig airways. Eur. J. Pharmacol. 198:219-221.
6. G-nitro-arginine on field stimulation induced contractions and acetylcholine release in guinea-pig isolated tracheal smooth muscle. Biochem. Biophys. Res. Commun. 179:1017-1022.
7. G-nitro-L-arginine of nonadrenergic noncholinergic relaxations of human isolated central and peripheral airways. Am. Rev. Respir. Dis. 146:1543-1547.
8. Belvisi, M. G., C. D. Stretton, M. H. Yacoub, and P. J. Barnes. 1992. Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans. Eur. J. Pharmacol. 210:221-222.
9. Loenders, B., P. G. Jorens, and A. G. Herman. 1996. Epithelial modulation of cholinergic responses in rabbit trachea is partly due to neutral endopeptidase activity. Eur. J. Pharmacol. 296:89-96.
10. 2-adrenoceptor activation augments acetylcholine release from tracheal parasympathetic nerves. Am. J. Physiol. 268:L950-L956.
11. Griffith, O., and S. S. Gross. 1996. Inhibitors of nitric oxide synthases. In M. Feelisch and J. S. Stamler, editors. Methods in Nitric Oxide Research. John Wiley & Sons Ltd. New York. 187-208.
12. Tschirhart, E., N. Frossard, C. Bertrand, and Y. Landry. 1987. Arachidonic acid metabolites and airway epithelium-dependent relaxant factor. J. Pharmacol. Exp. Ther. 243:310-316.
13. 2. Adv. Prostaglandin Thromboxane Res. 1:461-475.
14. Pasargiklian, M., S. Bianco, L. Allegra, N. E. Moavero, G. Petrigni, M. Robuschi, and A. Grugni. 1977. Aspects of bronchial reactivity to prostaglandins and aspirin in asthmatic changes. Respiration 34:79-91.
15. Knight, D. A., G. A. Stewart, and P. J. Thompson. 1995. Epithelium derived inhibitory prostanoids modulate human bronchial smooth muscle responses to histamine. Eur. J. Pharmacol. 272:1-11.
16. Huang, P. L., Z. Huang, H. Mashimo, K. D. Bloch, M. A. Moskowitz, J. A. Bevan, and M. C. Fishman. 1995. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 377:239-242.
17. Huang, Z., P. L. Huang, N. Panahian, T. Dalkara, M. C. Fishman, and M. A. Moskowitz. 1995. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265:1883-1885.
18. Riveros-Moreno, V., B. Heffernan, B. Torres, A. Chubb, I. Charles, and S. Moncada. 1995. Purification to homogeneity and characterisation of rat brain recombinant nitric oxide synthase. Eur. J Biochem. 230:52-57.
19. Rodrigo, J., D. R. Springall, D. Uttenthal, M. L. Bentina, F. Abadia-Molina, V. Riveros-Moreno, R. Martinez-Marillo, J. M. Polak, and S. Moncada. 1994. Localization of nitric oxide synthase in the adult rat brain. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 345:175-221.
20. Shu, S., G. Ju, and L. Fan. 1988. The glucose-oxidase DAB-nickel method in peroxidase histochemistry of the nervous system. Neurosci. Lett. 85:169-171.
21. Tyler, W. S. 1983. Small airways and terminal units. Am. Rev. Respir. Dis. 128:S32-S36.
22. Salvemini, D., K. Seibert, J. L. Masferrer, T. P. Misko, M. G. Currie, and P. Needleman. 1994. Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation. J. Clin. Invest. 93:1940-1947.
23. Salvemini, D., S. L. Settle, J. L. Masferrer, K. Seibert, M. G. Currie, and P. Needleman. 1995. Regulation of prostaglandin production by nitric oxide; an in vivo analysis. Br. J. Pharmacol 114:1171-1178.
24. Davidge, S. T., P. N. Baker, M. K. McLaughlin, and J. M. Roberts. 1995. Nitric oxide produced by endothelial cells increases production of the eicosanoids through activation of prostaglandin H synthase. Circ. Res. 77:274-283.
25. Marotta, P., L. Sautebin, and M. Di Rosa. 1992. Modulation of the induction of nitric oxide synthase by eicosanoids in the murine macrophage cell line J774. Br. J. Pharmacol. 107:640-641.
26. Illiano, S., R. Marsault, J.-J. Descombes, T. Verbeuren, and P. M. Vanhoutte. 1996. Regulation of nitric oxide-like activity by the prostanoids in smooth muscle of the canine saphenous vein. Br. J. Pharmacol. 117:360-364.
27. McGrogan, I., and E. E. Daniel. 1996. Release and actions of inhibitory prostaglandins from canine tracheal epithelium. Can. J. Physiol. Pharmacol. 74:1055-1060.
28. Churchill, L., F. H. Chilton, J. H. Resau, W. C. Bascom, W. C. Hubbard, and D. Proud. 1989. Cyclooxygenase metabolism of endogenous arachidonic acid by cultured human tracheal epithelial cells. Am. J. Physiol. 140:449-459.
29. 2 by cultured airway smooth muscle cells and its inhibition by prostaglandin synthase inhibitors. Br. J. Pharmacol. 111:983-988.
30. + channels. Am. J. Physiol. 40:H1498-H1506.
31. Kobzik, L., D. S. Bredt, C. J. Lowenstein, J. Drazen, B. Gaston, D. Sugarbaker, and J. S. Stamler. 1993. Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am. J. Respir. Cell Mol. Biol. 9:371-377.
32. Watkins, D. N., D. J. Peroni, K. A. Basclain, M. J. Garlepp. and P. J. Thompson. 1997. Expression and activity of nitric oxide synthases in human airway epithelium. Am. J. Respir. Cell Mol. Biol. 16:629-639.
33. Ito, Y., and K. Tajima. 1981. Actions of indomethacin and prostaglandins on neuroeffector transmission in the dog trachea. J. Physiol. (Lond.) 319:379-392.
34. 2 on excitatory neuro-effector transmission in the human bronchus. Prostaglandins 39:639-655.