Insulin resistance and hyperinsulinemia: Why are they important?

Current Opinion in Endocrinology and Diabetes

Volumn 6, Issue SUPPL. 1, 1999, Pages

  Ferrannini, Ele ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ATHEROSCLEROSIS; CONFERENCE PAPER; DISEASE ASSOCIATION; HUMAN; HYPERINSULINEMIA; HYPERLIPIDEMIA; HYPERTENSION; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; UREMIA;

EID: 0033452736     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (25)

1. Ferrannini E: Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. Endocr Rev 1998, 19:477-490.
2. nd edition. Oxford: Blackwell Science Ltd; 1997, pp. 17.1-17.3.
3. DeFronzo RA, Tobin JD, Andres R: Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979, 237:E214-E223.
4. Ferrannini E, Natali A, Bell P, et al.: Insulin resistance and hypersecretion in obesity. J Clin Invest 1997, 100:1166-1173.
5. Spinas GA, Laffranchi R, Francoys I, et al.: The early phase of glucose-stimulated insulin secretion requires nitric oxide. Diabetologia 1998, 41:292-299.
6. Groop LC, Widén E, Ferrannini E: Insulin resistance and insulin deficiency in the pathogenesis of type 2 diabetes: errors of metabolism or methods? Diabetologia 1993, 36:1326-1331.
7. Ferrannini E, Camastra S, Coppack SW, et al.: Insulin action and non-esterified fatty acids. Proc Nutr Soc 1997, 56:753-761.
8. Golay A, Swislocki AL, Chen YD, et al.: Relationships between plasma free fatty acid concentration, endogenous glucose production, and fasting hyperglycemia in normal and non-insulin-dependent diabetic individuals. Metabolism 1987, 36:692-696.
9. Frayn KN, Williams CM, Arner P: Are increased plasma non-esterified fatty acid concentrations a risk marker for coronary heart disease and other chronic diseases? Clin Sci 1996, 90:243-253.
10. Sako Y, Grill VE: A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation. Endrocrinology 1990, 127:1580-1589.
11. Zhou YP, Grill VE: Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 1994, 93:870-876.
12. Leahy JL, Cooper HE, Deal DA, et al.: Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. J Clin Invest 1986, 77:908-915.
13. Steinberg D: Antioxidants in the prevention of human atherosclerosis. Circulation 1992, 85:2338-2344.
14. Dieber-Rotheneder M, Puhl H, Waeg G, et al.: Effect of oral supplementation with D-alfa-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation. J Lipid Res 1991, 32:1325-1332.
15. Rimm EB, Stampfer MJ, Ascherio A, et al.: Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993, 328:1450-1456.
16. Stampfer MJ, Hennekens CH, Manson JE, et al.: Vitamin E consumption and the risk of coronary heart disease in women. N Engl J Med 1993, 328:1444-1449.
17. Quiñones-Galvan A, Muscelli E, Catalano C, et al.: Insulin decreases circulating vitamin E levels in humans. Metabolism 1996, 45:998-1003.
18. Ferrannini E, Natali A, Capaldo B, et al.: Insulin resistance, hyperinsulinemia, and blood pressure. Role of age and obesity. Hypertension 1997, 30:1144-1149.
19. Muscelli E, Natali A, Bianchi S, et al.: Effect of insulin on renal sodium and uric acid handling in essential hypertension. Am J Hypertens 1996, 9:746-752.
20. Weidmann P, Ferrari P: Central role of sodium in hypertension in diabetic subjects. Diabetes Care 1991, 14:220-232.
21. Muscelli E, Emdin M, Natali A, et al.: Cardiac effects of insulin in humans: influence of obesity. J Clin Endocrinol Metab 1998, 83:2084-2090.
22. Muscelli E, Camastra S, Catalano C, et al.: Metabolic and cardiovascular assessment in moderate obesity: effect of weight loss. J Clin Endocrinol Metab 1997, 82:2937-2943.
23. Baldi S, Natali A, Buzzigoli G, et al.: In vivo effect of insulin on intracellular calcium concentrations: relation to insulin resistance. Metabolism 1996, 45:1402-1407.
24. Bianchi S, Bigazzi R, Valtriani C, et al.: Elevated serum insulin levels in patients with essential hypertension and microalbuminuria. Hypertension 1994, 23:681-687.
25. Catalano C, Muscelli E, Quiñones-Galvan A, et al.: Effect of insulin on systemic and renal handling of albumin in nondiabetic and NIDDM subjects. Diabetes 1997, 46:868-875.