메뉴 건너뛰기




Volumn 15, Issue 1, 1999, Pages 63-77

Synthesis and mechanism of action of novel thiocarbamate inhibitors of human leukocyte elastase

Author keywords

Human leukocyte elastase (HLE); Peptidyl thiocarbamate inhibitors; Polymers

Indexed keywords

ELASTASE INHIBITOR; LEUKOCYTE ELASTASE; THIOCARBAMIC ACID;

EID: 0033452265     PISSN: 87555093     EISSN: None     Source Type: Journal    
DOI: 10.1080/14756369909030341     Document Type: Article
Times cited : (6)

References (14)
  • 3
    • 0021919760 scopus 로고
    • Elastase and emphysema. Current assessment of the protease-antiprotease hypothesis
    • Janoff, A. and Carp, H. (1985) Elastase and emphysema. Current assessment of the protease-antiprotease hypothesis. Am. Rev. Respir. Dis., 132, 417-433.
    • (1985) Am. Rev. Respir. Dis. , vol.132 , pp. 417-433
    • Janoff, A.1    Carp, H.2
  • 4
    • 0022494480 scopus 로고
    • Peptidyl carbamates incorporating amino acid isosteres as novel elastase inhibitors
    • Digenis, G A , Agha, B J , Tsuji, K., Kato, M. and Shinogi, M (1986) Peptidyl carbamates incorporating amino acid isosteres as novel elastase inhibitors J. Med. Chem., 29, 1468-1476
    • (1986) J. Med. Chem. , vol.29 , pp. 1468-1476
    • Digenis, G.A.1    Agha, B.J.2    Tsuji, K.3    Kato, M.4    Shinogi, M.5
  • 5
    • 0027369525 scopus 로고
    • Peptidyl carbamates as novel elastase inhibitors: Structure-activity relationship studies
    • Kato, M., Agha, B.J., Raheem, A., Tsuji, K., Banks, W.R. and Digenis, G.A. (1993) Peptidyl carbamates as novel elastase inhibitors: structure-activity relationship studies. J. Enz. Inhib., 7, 105-130.
    • (1993) J. Enz. Inhib. , vol.7 , pp. 105-130
    • Kato, M.1    Agha, B.J.2    Raheem, A.3    Tsuji, K.4    Banks, W.R.5    Digenis, G.A.6
  • 6
    • 0027723274 scopus 로고
    • Peptidyl carbamates as human leukocyte elastase inhibitors: Design and synthesis of desmosine-like tetrapeptidyl carbamate inhibitors
    • Digenis, G.A., Banks, W.R., Kato, M., Rencher, W.F. and Agha, B J. (1993) Peptidyl carbamates as human leukocyte elastase inhibitors: design and synthesis of desmosine-like tetrapeptidyl carbamate inhibitors. J. Enz. Inhib., 7, 275-301.
    • (1993) J. Enz. Inhib. , vol.7 , pp. 275-301
    • Digenis, G.A.1    Banks, W.R.2    Kato, M.3    Rencher, W.F.4    Agha, B.J.5
  • 7
    • 0027740035 scopus 로고
    • Mechanistic study of HLE inhibition using dual labeled macromolecular inhibitor
    • Noskova, D., Mohammadi, F., Savidge, S.J. and Digenis, G A. (1993) Mechanistic study of HLE inhibition using dual labeled macromolecular inhibitor. J. Enz. Inhib., 7, 303-309.
    • (1993) J. Enz. Inhib. , vol.7 , pp. 303-309
    • Noskova, D.1    Mohammadi, F.2    Savidge, S.J.3    Digenis, G.A.4
  • 9
    • 0031036436 scopus 로고    scopus 로고
    • Synthetic macromolecular inhibitors of human leukocyte elastase. 2. Effect of loading of a peptidyl carbamate inhibitor and molecular size of polymer backbone on its inhibitory capacity
    • Mohammadi, F., Nosek, D. and Digenis, G.A. (1997) Synthetic macromolecular inhibitors of human leukocyte elastase. 2. Effect of loading of a peptidyl carbamate inhibitor and molecular size of polymer backbone on its inhibitory capacity. J Enz. Inhib., 11, 183-198.
    • (1997) J Enz. Inhib. , vol.11 , pp. 183-198
    • Mohammadi, F.1    Nosek, D.2    Digenis, G.A.3
  • 10
    • 0023103128 scopus 로고
    • Responses of the L5178Y tK-/tK- Mouse lymphoma cell forward mutation assay to coded chemicals. I: Results for nine compounds
    • McGregor, D.B., Martin, R., Cattanach, P., Edwards, I., McBride, D. and Caspary, W.J. (1987) Responses of the L5178Y tK-/tK- mouse lymphoma cell forward mutation assay to coded chemicals. I: Results for nine compounds. Environ. Mutagen., 9, 143-160.
    • (1987) Environ. Mutagen. , vol.9 , pp. 143-160
    • McGregor, D.B.1    Martin, R.2    Cattanach, P.3    Edwards, I.4    McBride, D.5    Caspary, W.J.6
  • 11
    • 0015392635 scopus 로고
    • Hydrolysis of unstable carbamates followed with a stopped-flow technique
    • Branstad, J.O. and Ekberg, G (1972) Hydrolysis of unstable carbamates followed with a stopped-flow technique Acta. Pharm. Suecica, 283-288.
    • (1972) Acta. Pharm. Suecica , pp. 283-288
    • Branstad, J.O.1    Ekberg, G.2
  • 12
    • 0019282838 scopus 로고
    • Pathophysiological interpretation of kinetic constants of protease inhibitors
    • Bieth, J.G. (1980) Pathophysiological interpretation of kinetic constants of protease inhibitors. Bull. Europ. Phyiopath Resp., 16(Suppl.), 183-195.
    • (1980) Bull. Europ. Physiopath Resp. , vol.16 , Issue.SUPPL. , pp. 183-195
    • Bieth, J.G.1
  • 13
    • 0001130324 scopus 로고
    • A new tert-butylcarbonylating reagent, 2-(tert-butoxy-carbonyl-oxyimino)-2-phenylacetonitrile
    • Itoh, M., Hagiwara, D. and Kamiya, T. (1975) A new tert-butylcarbonylating reagent, 2-(tert-butoxy-carbonyl-oxyimino)-2-phenylacetonitrile. Tetrahedron Lett., 4393.
    • (1975) Tetrahedron Lett. , pp. 4393
    • Itoh, M.1    Hagiwara, D.2    Kamiya, T.3
  • 14
    • 0018747530 scopus 로고
    • Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase
    • Nakajima, K., Powers, J C., Ashe, B.M. and Zimmerman, M. (1979) Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. J. Biol. Chem., 254, 4027-4032.
    • (1979) J. Biol. Chem. , vol.254 , pp. 4027-4032
    • Nakajima, K.1    Powers, J.C.2    Ashe, B.M.3    Zimmerman, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.