Synthetic macromolecular inhibitors of human leukocyte elastase. 2. Effect of loading of a peptidyl carbamate inhibitor and molecular size of polymer backbone on its inhibitory capacity

Journal of Enzyme Inhibition

Volumn 11, Issue 3, 1997, Pages 183-198

  Mohammadi, Fatemeh ^a   Nosek, Dagmar ^a   Digenis, George A ^a  

^a University of Kentucky   (United States)

Author keywords

Effect of loading; Enzyme inhibitor complex; Human leukocyte elastase (HLE); Inhibitory capacity; Mechanism of inhibition; Molecular size; p nitrophenyl N succinyl L alanyl L alanyl L prolylmethyl N isopropylcarbamate; Peptidyl carbamate; PHEA; poly , N (2 hydroxyethl) D,L aspartamide ; Polymeric inhibitor; Polysuccinimide

Indexed keywords

CARBAMIC ACID; ELASTASE INHIBITOR; LEUKOCYTE ELASTASE; POLYMER;

ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROLYSIS; MOLECULAR SIZE; PRIORITY JOURNAL;

EID: 0031036436     PISSN: 87555093     EISSN: None     Source Type: Journal    
DOI: 10.3109/14756369709027649     Document Type: Article

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