Cell irradiation caused by diagnostic nuclear medicine procedures: Dose heterogeneity and biological consequences

European Journal of Nuclear Medicine

Volumn 26, Issue 12, 1999, Pages 1617-1626

  Gardin, Isabelle ^a,b   Faraggi, Marc ^a   Le Guludec, Dominique ^a   Bok, Bernard ^a  

^a BICHAT HOSPITAL   (France)

^b BEAUJON HOSPITAL   (France)

Author keywords

Cellular dosimetry; Radiobiology Radio pharmaceutical

Indexed keywords

INDIUM 111; IODINE 123; RADIOISOTOPE; TECHNETIUM 99M; THALLIUM 201;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; DIAGNOSTIC IMAGING; DNA DAMAGE; DOSIMETRY; MOUSE; NONHUMAN; PHOTON EMISSION TOMOGRAPHY; RADIATION DOSE; RADIOBIOLOGY;

HUMANS; LEUKOCYTES, MONONUCLEAR; LIVER; LUNG; RADIATION DOSAGE; RADIONUCLIDE IMAGING; RADIOPHARMACEUTICALS; SUBCELLULAR FRACTIONS;

EID: 0033451895     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002590050504     Document Type: Article

References (80)

1. 1. Loevinger RL, Budinger TF, Watson EE. MIRD primer for absorbed dose calculations. New York: The Society of Nuclear Medicine, 1988.
2. 2. ICRP 53. Radiation dose to patients from radiopharmaceuti-cals. ICRP Publication 38. Oxford: Pergamon, 1992.
3. 3. Ernst M, Freed ME, Zametkin AJ. Health hazards of radiation exposure in the context of brain imaging research: special consideration for children. J Nucl Med 1998; 39: 689-698.
4. 4. Hindie E, Colas-Linhart N, Petiet A, Bok B. Microauto-radiographic study of Tc-99 m colloid uptake by the rat liver. J Nucl Med 1988; 29: 1118-1121.
5. 5. Puncher MRB, Blower PJ. Radionuclide targeting and dosimetry at the microscopic level: the role of microautoradiography. Eur J Nucl Med 1994; 21: 1347-1365.
6. 6. Makrigiorgos GM, Adelstein SJ, Kassis AI. Limitation of conventional internal dosimetry at the cellular level. J Nucl Med 1989; 30: 1856-1864.
7. 7. Kassis AI, Adelstein SJ, Haydock C, Sastry KSR. Thallium-201: an experimental and a theoretical radiobiological approach to dosimetry. J Nucl Med 1983; 24: 1164-1175.
8. 8. Rao DV, Sastry KSR, Grimmond HE, Howell RW, Govelitz GF, Lanka VK, Mylavarapu VB. Cytotoxicity of some indium radiopharmaceuticals in mouse testes. J Nucl Med 1988; 29: 375-384.
9. 9. Narra VR, Howell RW, Harapanhalli RS, Sastry KSR, Rao DV Radiotoxicity of some iodine-123, iodine-125 and iodine-131-labeled compounds in mouse testes: implications for radiopharmaceutical design. J Nucl Med 1992; 33: 2196-2201.
10. 10. Faraggi M, Gardin I, de Labriolle-Vayley C, Moretti JL, Bok B. The influence of tracer localization on the electron dose rate delivered to the cell nucleus by some radionuclides used in diagnostic nuclear medicine procedures. J Nucl Med 1994; 35: 113-119.
11. 11. Goddu SM, Howell RW, Bouchet LG, Bolch WE, Rao DV MIRD cellular S values. Reston: The Society of Nuclear Medicine, 1997.
12. 201T1. Eur J Nucl Med 1998; 25: 205-214.
13. 13. Rao DV, Govelitz GF, Sastry KSR. Radiotoxicity of thallium-201 in mouse testes: inadequacy of conventional dosimetry. J Nucl Med 1983; 24: 145-153.
14. 14. Humm JL, Howell RW, Rao DV Dosimetry of Auger-electron-emitting radionuclides: report No. 3 of AAPM nuclear medicine task group No. 6. Med Phys 1994; 21: 1901-1915.
15. 15. Howell RW Radiation spectra for Auger-electron emitting radionuclides: report No. 2 of AAPM nuclear medicine task group No. 6. Med Phys 1992; 19: 1372-1383.
16. 16. Gardin I, Faraggi M, Huc E, Bok B. Modelling of the relationship between cell dimensions and mean dose delivered to the cell nucleus: application to five radionuclides used in nuclear medicine. Phys Med Biol 1995; 40: 1001-1014.
17. 17. Howell RW The MIRD schema: from organ to cellular dimensions. J Nucl Med 1994; 35: 531-533.
18. 18. Howell RW, Wessels BW, Loevinger R. The MIRD perspective 1999. J Nucl Med 1999; 40: 3S-10S.
19. 19. Bardiès M, Myers MJ. Computational methods in radionuclide dosimetry. Phys Med Biol 1996; 41: 1941-1955.
20. 20. Nikiforidis G, Vassilakos P, Karatrandou A, Barbalias G. In vivo estimation of radiation dose in renal pelvis and parenchyma during renography. Nucl Med Commun 1995; 16: 47-55.
21. 99mTc. J Nucl Med 1999; 40: 868-875.
22. 22. Gardin I, Colas-Linhart N, Petiet A, Bok B. Dosimetry at the cellular level of Kupffer cells after technetium-99m-sulphur colloid injection. J Nucl Med 1992; 33: 380-384.
23. 23. de Labriolle-Vaylet C, Colas-Linhart N, Sala-Trepat M, Petiet A, Voisin P, Bok B. Biological consequences of the heterogeneous irradiation of lymphocytes during technetium-99 m hexamethylpropylene amine oxime white blood cells labelling. Eur J Nucl Med 1998; 25: 1423-1428.
24. 24. Makrigiorgos GM, Adelstein SJ, Kassis AI. Cellular radiation dosimetry and its implications for estimation of radiation risks: illustrative results with technetium 99m-labeled microspheres and macroaggregates. JAMA 1990; 264: 592-596.
25. 25. Robinson MS, Colas-Linhart NC, Guiraud-Vitaux FM, Petiet A, Bok B. Heterogeneous distribution of technetium-99m-labeled microspheres in rat lungs: microautoradiographic evidence and dosimetric consequences. J Nucl Med 1997; 38: 650-654.
26. 26. Goddu SM, Howell RW, Rao DV Cellular dosimetry: absorbed fractions for monoenergetic electron and alpha particle sources and S-values for radionuclides uniformly distributed in different cell compartments. J Nucl Med 1994; 35: 303-316.
27. 27. Goddu SM, Rao DV, Howell RW. Multicellular dosimetry for micrometastases: dependence of self-dose versus cross-dose to cell nuclei on type and energy of radiation and subcellular distribution of radionuclides. J Nucl Med 1994; 35: 521-530.
28. 28. Nettleton JS, Lawson RS. Cellular dosimetry of diagnostic radionuclides for spherical and ellipsoidal geometry. Phys Med Biol 1996; 41: 1845-1854.
29. 29. Snider WS, Ford MR, Warner GG. MIRD Pamphlet Number 5, Revised. Estimates of specific absorbed fractions for photon sources uniformily distributed in various organs of a heterogeneous phantom. New York: The Society of Nuclear Medicine, 1978.
30. 30. Barth RF, Clancy J, Pugh JM. Autoradiographic studies on the cellular uptake of technetium-99 m and chromium-51. J Microscopy 1977; 2: 211-222.
31. 31. Puncher MRB, Blower PJ. Autoradiography and density gradient separation of technetium-99m-exametazime (HMPAO) labelled leucocytes reveals selectivity for eosinophils. Eur J Nucl Med 1994; 21: 1175-1182.
32. 2: an investigation of the labelling process by autoradiography. Eur J Nucl Med 1995; 22: 101-107.
33. 33. Lam ASK, Puncher MRB, Blower PJ. In vitro and in-vivo studies with pentavalent technetium-99 m dimercaptosuccinic acid. J Nucl Med 1996; 37: 1575-1582.
34. 34. Morrell EM, Tompkins RG, Fishman AJ, Wilkinson RA, Burke JF, Rubin RH, Strauss HW, Yarmush ML. Autoradiographic method for quantitation of radiolabeled proteins in tissues using indium-111. J Nucl Med 1989; 30: 1538-1545.
35. 35. Puncher MRB, Blower PJ. Frozen section microautoradiography in the study of radionuclide targeting: application to indium-111-oxime-labeled leucocytes. J Nucl Med 1995; 36: 499-505.
36. 36. Barbu M, Colas-Linhart N, Bok B. Technetium 99 m autoradiography of labelled white cells. Acta Haematol 1984; 71: 13-17.
37. 37. Fourré C, Petiet A, Colas-Linhart N. Mutual contribution by "track" microautoradiography method (TMAR) and secondary ion mass spectrometry (SIMS) microscopy: prospects in technetium dosimetry at the cellular level. Cell Mol Biol 1996; 42: 385-393.
38. 38. Lanièce P, Charon Y, Dumas S, Mastrippolito R, Pinot L, Tricoire H, Valentin L. HRRI: a high resolution radioimager for fast direct quantification in situ hybridization experiments. Biotechniques 1994; 17: 338-345.
39. 39. Charpak G, Dominik W, Zaganidis N. Optical imaging of the spatial distribution of β-particles emerging from surfaces. Proc Natl Acad Sci USA 1989; 86: 1741-1745.
40. 125I-ligand receptor binding and pharmacological studies. Histochem J 1996; 28: 801-809.
41. 41. Fourré C, Halpern S, Jeusset J, Clerc J, Fragu P. Significance of secondary ion mass spectrometry microscopy for technetium-99 m mapping in leukocytes. J Nucl Med 1992; 33: 2162-2166.
42. 42. Clerc J, Mardon K, Galons H, Loc'h C, Lumbroso J, Merlet P, Zhu J, Jeusset J, Syrota A, Fragu P. Assessing intratumor distribution and uptake with MBBG versus MIBG imaging and targeting xenografted PC12-pheochromocytoma cell line. J Nucl Med 1995; 36: 859-866.
43. 43. Berry JP, Escaig F, Poupon MF, Galle P. Localization of gallium in tumor cells. Electron microscopy, electron probe microanalysis and analytical ion microscopy. Int J Nucl Med Biol 1983; 10: 199-204.
44. 44. Telenczak P, Ricard M, Halpern S, Fragu P. A method to evaluate the tissue absorbed dose in metabolic radiotherapy: preliminary results with MIBG. In: Bennighoven A, Evans C, McKeegan K, Storms H, eds. Secondary ion mass spectrometry, SIMS VII. Chichester: Wiley; 1990: 315-318.
45. 45. Trebbia P, Bonnet N. EELS elemental mapping with unconventional methods. I. Theoretical basis-image analysis with multivariate statistics and entropy concepts. Ultramicroscopy 1990; 34: 165-178.
46. 46. Piwnica-Worms D, Kronauge J, Davison A, Jones AG, Ingram P LeFurgey M, Lieberman M. Mitochondrial localisation of Tc-MIBI in cultured chick heart cells by electron probe X-ray microanalysis [abstract]. J Nucl Med 1990; 31: 748.
47. 47. Makrigiorgos GM, Ito S, Baranowska-Kortylewicz J, Vinter DW, Iqbal A, Van den Abbeele AD, Adelstein SJ, Kassis AI. Inhomogeneous deposition of radiopharmaceuticals at the cellular level: experimental evidence and dosimetric implications. J Nucl Med 1990; 31: 1358-1363.
48. 48. Bassano DA, McAfee JG. Cellular radiation doses of labeled neutrophils and platelets. J Nucl Med 1979; 20: 255-259.
49. 99mTc. Radiat Res 1983; 94: 263-279.
50. 50. Ten Berge RJ. Labeling with indium-111 has detrimental effects on human lymphocytes: concise communication. J Nucl Med 1983; 24: 615-620.
51. 111Indium-labeled human alveolar macrophages and monocytes: function and ultrastructure. J Immunol Methods 1980; 36: 99-107.
52. 52. Silvester DJ, Waters SL. Dosimetry of radiolabelled blood cells. Int J Nucl Med Biol 1983; 10: 141-144.
53. 53. Makrigiorgos G, Adelstein SJ, Kassis AI. Auger electron emitters: Insights gained from in vitro experiments. Radiat Environ Biophys 1990; 29: 75-91.
54. 54. Sastry KSR. Biological effects of the Auger emitter iodine-125: a review. Report No. 1 of AAPM Nuclear Medicine Task Group No. 6. Med Phys 1992; 19: 1361-1370.
55. 55. Hofer KG. Biophysical aspects of Auger processes: a review. Acta Oncol 1996; 35: 789-796.
56. 131iodo-2-deoxiuridine. Radiat Res 1989; 118: 532-544.
57. 57. Makrigiorgos GM, Berman RM, Baranowska-Kortylewicz J, Bump E, Humm JL, Adelstein SJ, Kassis AI. DNA damage produced in V79 cells by DNA-incorporated iodine-123: a comparison with iodine-125. Radiat Res 1992; 129: 309-314.
58. 3H: nuclear versus cytoplasmic radiation effects in murine L1210 leukemia. Int J Radiat Biol 1975; 28: 225-241.
59. 59. Bloomer WD, McLaughlin WH, Weichselbaum RR, Hanson RN, Adelstein SJ, Seitz DE. The role of subcellular localization in assessing the cytotoxicity of iodine-125 labelled iodo-deoxyuridine, iodotamoxifen and iodoantipyrine. J Radioanal Chem 1981; 65: 209-221.
60. 125I in mammalian cells. Radiat Res 1989; 111: 305-318.
61. 3HTdR. Radiat Res 1976; 67: 332-343.
62. 125I compared with that of densely ionising alpha-particles. Lancet 1989; II: 650-653.
63. 63. Howell RW, Rao DV, Hou DY, Narra VR, Sastry KSR. The question of RBE and quality factor for Auger emitters incorporated into proliferating mammalian cells. Radiat Res 1991; 128: 282-293.
64. 125I: cysteamine as a radioprotector against Auger cascades in vivo. Radiat Res 1990; 124: 188-193.
65. 65. Rao DV, Narra VR, Howell RW, Lanka VK, Sastry KSR. Induction of sperm head abnormalities by incorporated radionuclides: dependence on subcellular distribution, type of radiation, dose rate, and presence of radioprotectors. Radiat Res 1991; 125: 89-97.
66. 66. Narra VR, Harapanhalli RS, Goddu SM, Howell RW, Rao DV. Radioprotection against biological effects of internal radionuclides in vivo by S-(2-aminoethyl)isothiouronium bromide hydrobromide (AET). J Nucl Med 1995; 36: 259-266.
67. 67. Goddu SM, Narra VR, Harapanhalli RS, Howell RW, Rao DV Radioprotection by DMSO against the biological effects of incorporated radionuclides in vivo. Acta Oncol 1996; 35: 901-907.
68. 68. Howell RW, Narra VR, Sastry KSR, Rao DV On the equivalent dose for Auger electrons emitters. Radiat Res 1993; 134: 71-78.
69. 69. Goddu SM, Howell RW, Rao DV. Calculation of equivalent dose for Auger electron emitting radionuclides distributed in human organs. Acta Oncol 1996; 35: 909-916.
70. 70. De Sombre ER, Shafii B, Hanson RN, Kuivanen PC, Hughes A. Estrogen receptor-directed radiotoxicity with Auger electrons - specificity and mean lethal dose. Cancer Res 1992; 52: 5752-5758.
71. 71. Mariani G, Cei A, Collechi P, Baranowska-Kortylewicz J, Van Den Abbeele AD, Di Luca L, Di Stefano R, Viacava P, Ferdeghini EM, Di Sacco SD, Salvadori PA, Bevilacqua G, Adelstein SJ, Mosca F, Kassis AI. Tumor targeting in vivo and metabolic fate of 5-[iodine-125]iodo-2'-deoxyuridine following intratumoral injection in patients with colorectal cancer. J Nucl Med 1993; 34: 1175-1183.
72. 125I]iodo-2'-deoxyuridine in patients with liver metastases from colorectal cancer. Acta Oncol 1996; 35: 941-945.
73. 73. Adelstein SJ, Kassis AI, Baranowska-Kortylewicz J, Van Den Abbeele AD, Mariani G, Ito S. Potential for tumor therapy with iodine-125 labeled immunoglobulins. Nucl Med Biol 1991; 18: 43-44.
74. 74. O'Donoghue JA, Wheldon TE. Targeted radiotheraphy using Auger electron emitters. Phys Med Biol 1996; 41: 1973-1992.
75. 99mTc radiopharmaceuticals. Med Phys 1994; 21: 1921-1926.
76. 99mTc-HMPAO white blood cells labeling. Sixth International Radiopharmaceutical Dosimetry Symposium, 7-10 May 1996, Gatlinberg, Tenn., USA. ORISE 99-0164 (DE-AC05-76OR00033).
77. 77. Kassis AI, Adelstien SJ. Does nonuniformity of dose have implications for radiation protection? J Nucl Med 1992; 33: 384-387.
78. 78. Sigg M, Crompton NEA, Burkart W. Enhanced neoplastic transformation in an inhomogeneous radiation field: an effect of the presence of heavily damaged cells. Radiat Res 1997; 148: 543-547.
79. 79. Mill AJ, Charles MW, Darley PJ. Enhanced neoplastic transformation in an inhomogeneous radiation field: an effect of the presence of heavily damaged cells: a critical appraisal [letter to the editor]. Radiat Res 1998; 149: 649-651.
80. 80. Seymour C, Motherstill C. Cell communication and the "bystander effect". [Letter to the editor]. Radiat Res 1998; 149: 505-506.