Effects of lithium and amphetamine on inositol metabolism in the human brain as measured by 1H and 31P MRS

Biological Psychiatry

Volumn 46, Issue 12, 1999, Pages 1634-1641

  Silverstone, Peter H ^a   Rotzinger, Susan ^a   Pukhovsky, Andrew ^a   Hanstock, Christopher C ^b  

^a Psychology   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE; INOSITOL; INOSITOL PHOSPHATE; LITHIUM; PLACEBO;

ADULT; ARTICLE; BRAIN METABOLISM; BRAIN REGION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MANIC DEPRESSIVE PSYCHOSIS; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; ORAL DRUG ADMINISTRATION; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VOLUNTEER;

ADOLESCENT; ADULT; BRAIN; CENTRAL NERVOUS SYSTEM STIMULANTS; DEXTROAMPHETAMINE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INOSITOL; LITHIUM; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PHOSPHORUS ISOTOPES; REFERENCE VALUES; TRITIUM;

EID: 0033433979     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(99)00076-1     Document Type: Article

References (53)

1. Allison J.H., Blisner M.E., Holland W.H., Hipps P.P., Sherman W.R. Increased brain myo-inositol l-phosphate in lithium treated rats. Biochem Biophys Res Comm. 71:1976;664-670.
2. Barkai I.A., Dunner D.L., Gross H.A., Mayo P., Fieve R.R. Reduced myo-inositol levels in cerebrospinal fluid from patients with affective disorder. Biol Psychiatry. 13:1978;65-72.
3. Barnaby R.J. Mass assay for inositol l-phosphate in rat brain by high-performance liquid chromatography and pulsed amperometric detection. Anal Biochem. 199:1991;75-80.
4. Belmaker R.H., Agam G., van Calker D., Richards M.H., Kofman O. Behavioral reversal of lithium effects by four inositol isomers correlates perfectly with biochemical effects on the PI cycle Depletion by chronic lithium of brain inositol is specific to hypothalamus, and inositol levels may be abnormal in postmortem brain from bipolar patients . Neuropsychopharmacol. 19:1998;220-232.
5. Berridge M.J., Downes C.P., Hanley M.R. Lithium amplifies agonist-dependent phosphatidyl-inositol responses in brain and salivary glands. Biochem J. 206:1982;587-595.
6. Berridge M.J., Downes C.P., Hanley M.R. Neural and developmental actions of lithium a unifying hypothesis . Cell. 59:1989;411-419.
7. Berridge M.J., Irvine R.F. Inositol phosphates and cell signaling. Nature. 341:1989;197-204.
8. Bottomley P.A. Spatial localization in NMR spectroscopy in vivo. Ann NY Acad Sci. 508:1987;333-348.
9. Bruhn H, Stoppe G, Staedt J, Merboldt K D, Hänicke W, Frahm J (1993): Quantitative proton MRS in vivo shows cerebral myo-inositol and cholines to be unchanged in manic-depressive patients treated with lithium. In: Proceedings of the Society for Magnetic Resonance in Medicine. 1543.
10. lH NMR detection of cerebral myo-inositol. FEBS Lett. 187:1985;167-172.
11. Deicken R.F., Fein G., Weiner M.W. Abnormal frontal lobe phosphorus metabolism in bipolar disorder. Am J Psychiatry. 152:1995;915-918.
12. Deicken R.F., Weiner M.W., Fein G. Decreased temporal lobe phosphomonoesters in bipolar disorder. J Affect Dis. 33:1995;198-199.
13. Deutsch S.I., Stanley M., Banay-Schwartz M., et al. The effect of lithium on rat brain and erythrocyte glycine levels. Eur J Pharmacol. 75:1981;75-76.
14. Dunn O.J. Multiple comparisons among means. J Am Stat Assoc. 56:1961;52-64.
15. Elphick M., Taghavi Z., Powell T., Godfrey P.P. Alteration of inositol phospholipid metabolism in rat cortex by lithium but not carbamazepine. Eur J Pharmacol. 156:1988;411-414.
16. Godfrey P.P., McCkye S.J., White A.M., Wood A.J., Grahame-Smith D.G. Subacute and chronic in vivo lithium treatment inhibits agonist- and sodium fluoride-stimulated inositol phosphate production in rat cortex. J Neurochem. 52:1989;498-506.
17. Gordon RE, Ordidge RJ (1984): Volume selection for high resolution NMR studies. In: Proceedings of the Society of Magnetic Resonance in Medicine. Abstract 272.
18. Gyulai L., Bolinger L., Leigh J.S. Jr, Barlow C., Chance B. Phosphorylethanolamine - the major constituent of the phosphomonester peak observed by 31P-NMR on developing dog brain. FEBS Lett. 178:1984;137-142.
19. Hallcher L.M., Sherman W.R. The effect of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain. J Biol Chem. 255:1980;10896-10901.
20. Hirvonen M.R. Cerebral lithium, inositol and inositol monophosphates. Pharmacol Toxicol. 69:1991;22-27.
21. Hoebel B.G., Hernandez L., Schwartz D.H., Mark G.P., Hunter G.A. Microdialysis studies of brain norepinephrine, serotonin, and dopamine release during ingestive behavior Theoretical and clinical implications . Ann N Y Acad Sci. 575:1989;171-191.
22. Honchar M.P., Ackerman K.E., Sherman W.R. Evidence that phosphoinositide metabolism in rat cerebral cortex stimulated by pilocarpine, physostigmine, and pargyline in vivo is not changed by lithium treatment. J Neurochem. 53:1989;590-594.
23. Jenkinson S., Patel N., Nahorski S.R., Challis R.A.J. Comparative effects of lithium on the phosphoinositide cycle in rat cerebral cortex, hippocampus, and striatum. J Neurochem. 61:1993;1082-1090.
24. Karler R., Calder L.D., Thai L.H., Bedingfield B. A dopaminergic-glutamatergic basis for the action of amphetamine and cocaine. Brain Res. 658:1994;8-14.
25. 31P MRS. J Affect Disord. 22:1991;185-190.
26. Kato T., Takahashi S., Shioiri T., Inubushi T. Brain phosphorus metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopy. J Affect Disord. 26:1992;223-230.
27. 7Li magnetic resonance spectroscopy. J Affect Disord. 27:1993;53-59.
28. Kato T., Takahashi S., Shioiri T., Murashita J., Hamakawa H., Inubushi T. Reduction of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 magnetic resonance spectroscopy. J Affect Disord. 31:1994;125-133.
29. Kennedy E.D., Challiss R.A.J., Nahorski S. Lithium reduces the accumulation of inositol polyphosphate second messengers following cholinergic stimulation of cerebral cortex slices. J Neurochem. 53:1989;1652-1655.
30. Kuczenski R., Segal D.S. An escalating dose/multiple high-dose binge pattern of amphetamine administration results in differential changes in the extracellular dopamine response profiles in caudate-putamen and nucleus accumbens. J Neurosci. 17:1997;4441-4447.
31. + increases accumulation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in cholinergically stimulated brain cortex slices in guinea pig, mouse and rat. Biochem J. 282:1992;377-385.
32. Lin Tai-An, Zhang Jian-Ping, Sun G.Y. Metabolism of inositol 1,4,5-triphosphate in mouse brain due to decapitation ischaemic insult Effects of acute lithium administration and temporal relationship to diacylglycerols, free fatty acids and energy metabolites . Brain Res. 606:1993;200-206.
33. Majerus P.W., Connolly T.M., Bansal V.S., Inhorn R.C., Ross T.S., Lips D.L. Inositol phosphates Synthesis and degradation . J Biol Chem. 263:1988;3051-3054.
34. Manji H.K., Potter W.Z., Lenox R.H. Signal transduction pathways Molecular targets for lithium's actions . Arch Gen Psychiatry. 52:1995;531-543.
35. Mauri M.C., Percudani M., Regazzetti M.G., Altamura A.C. Alternative prophylactic treatments to lithium in bipolar disorders. Clin Neuropharmacol. 13:1990;S90-S96.
36. Moats R.A., Lien Y.H., Filippi D., Ross B.D. Decrease in cerebral inositols in rats and humans. Biochem J. 295:1993;15-18.
37. Moore GJ, Bebchuk JM, Manji HK (1997): Quantitative Proton MRS in Bipolar Affective Disorder: Monitoring of lithium induced modulation of brain myo-inositol. In: Proceedings of the International Society for Magnetic Resonance in Medicine. Abstract 1214.
38. Moore G.J., Bebchuk J.M., Parrish J.K., et al. Monitoring of lithium induced neurochemical changes in manic depressive illness In vivo investigation of the inositol depletion hypothesis [abstract] . Biol Psychiatry. 43:1998;23S.
39. Nahorski S.R., Ragan C.I., Challiss R.A.J. Lithium and the phosphoinositide cycle An example of uncompetitive inhibition and its pharmacological consequences . Trends Pharmacol Sci. 12:1991;297-303.
40. Newman M.E., Drummer D., Lerer B. Single and combined effects of desimipramine and lithium on serotonergic receptor number and second messenger function in rat brain. J Pharmacol and Exp Ther. 252:1990;826-831.
41. Ordidge R.J., Connelly A., Bohman J.A.B. Image-selected in vivo spectroscopy (ISIS). A new technique for spatially selective NMR spectroscopy. Mag Res Med. 66:1986;283-294.
42. Preece N.E., Gadian D.G., Houseman J., Williams S.R. Lithium-induced modulation of cerebral inositol phosphate metabolism in the rat a multinuclear magnetic resonance study in vivo . Lithium. 3:1992;287-297.
43. Prien R.F., Kupfer D.J., Mansky P.A., et al. Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders. Arch Gen Psychiatry. 41:1984;1096-1104.
44. Reid M.S., Hsu K., Berger S.P. Cocaine and amphetamine preferentially stimulate glutamate release in the limbic system Studies on the involvement of dopamine . Synapse. 27:1997;95-105.
45. Renshaw P.F., Summers J.J., Renshaw C.E., Hines K.G., Leigh J.S. Changes in the 31P-NMR spectra of cats receiving lithium chloride systematically. Biol Psychiatry. 21:1986;694-698.
46. 31P NMR spectroscopy of agonist-stimulated phosphatidylinositol metabolism in cat brain. Magnet Reson Med. 4:1987;221-226.
47. Seiden L.S., Sabol K.E., Ricaurte G.A. Amphetamine Effects on catecholamine systems and behavior . Ann Rev Pharmacol Toxicol. 32:1993;639-677.
48. Sharma R., Venkatasubramanian P.N., Bárány M., Davis J.M. Proton magnetic resonance spectroscopy of the brain in schizophrenic and affective patients. Schizophr Res. 8:1992;43-49.
49. Sherman W.R., Leavitt A.L., Honchar M.P., Hallcher L.M., Phillips B.E. Evidence that lithium alters phosphoinositide metabolism Chronic administration elevates primarily D-myo-inositol-1-phosphate in cerebral cortex of the rat . J Neurochem. 36:1981;1947-1951.
50. Sherman W.R., Munsell L.Y., Gish B.G., Honchar M.P. Effects of systematically administered lithium on phosphoinositide metabolism in rat brain, kidney, and testis. J Neurochem. 44:1985;798-807.
51. Shimon H., Agam G., Belmaker R.H., Hyde T., Kleinman J.E. Reduced inositol levels in frontal cortex of post-mortem brain from bipolar patients and suicides. Am J Psychiatry. 154:1997;1148-1150.
52. Silverstone P.H., Hanstock C.C., Fabian J., Staab R., Allen P.S. Chronic lithium does not alter myo-inositol or phosphomonoester concentrations in humans measured by MRS. Biol Psychiatry. 40:1996;235-246.
53. Sun G.Y., Navidi M., Yoa F.G., et al. Lithium effects on inositol phospholipids and inositol phosphates evaluation of an in vivo model for assessing polyphosphoinositide turnover in brain . J Neurochem. 58:1992;290-297.