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Volumn 19, Issue 3, 1998, Pages 220-232

Behavioral reversal of lithium effects by four inositol isomers correlates perfectly with biochemical effects on the PI cycle: Depletion by chronic lithium of brain inositol is specific to hypothalamus, and inositol levels may be abnormal in postmortem brain from bipolar patients

Author keywords

Bipolar disorder; Epi inositol; Frontal cortex; Hypothalamus; Inositol; Myo inositol

Indexed keywords

INOSITOL; INOSITOL PHOSPHATE; LITHIUM;

EID: 0032171218     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(98)00017-7     Document Type: Article
Times cited : (35)

References (62)
  • 2
    • 0028040850 scopus 로고
    • Effect of high-dose peripheral inositol: Brain inositol levels and prevention of behavioral changes due to inositol depletion
    • Agam G., Shapiro J., Bersudsky Y., Kofman O., Belmaker R.H. Effect of high-dose peripheral inositol. Brain inositol levels and prevention of behavioral changes due to inositol depletion Pharmacol Biochem Behav. 49:1994;341-343.
    • (1994) Pharmacol Biochem Behav , vol.49 , pp. 341-343
    • Agam, G.1    Shapiro, J.2    Bersudsky, Y.3    Kofman, O.4    Belmaker, R.H.5
  • 3
    • 0015242494 scopus 로고
    • Reduced brain inositol in lithium-treated rats
    • Allison J.H., Stewart M.A. Reduced brain inositol in lithium-treated rats. Nature. 233:1971;267-268.
    • (1971) Nature , vol.233 , pp. 267-268
    • Allison, J.H.1    Stewart, M.A.2
  • 5
    • 0018839864 scopus 로고
    • The effects of lithium on myo-inositol levels in layers of frontal cerebral cortex, in cerebellum, and in corpus callosum in rats
    • Allison J.H., Boshans R.L., Hallcher L.M., Packman P.M., Sherman W.R. The effects of lithium on myo-inositol levels in layers of frontal cerebral cortex, in cerebellum, and in corpus callosum in rats. J Neurochem. 34:1980;456-458.
    • (1980) J Neurochem , vol.34 , pp. 456-458
    • Allison, J.H.1    Boshans, R.L.2    Hallcher, L.M.3    Packman, P.M.4    Sherman, W.R.5
  • 6
    • 0017835310 scopus 로고
    • Reduced myo-inositol levels in cerebrospinal fluid from patients with affective disorder
    • Barkai I.A., Dunner D.L., Gross H.A., Mayo P., Fieve R.R. Reduced myo-inositol levels in cerebrospinal fluid from patients with affective disorder. Biol Pyschiatr. 13:1978;65-72.
    • (1978) Biol Pyschiatr , vol.13 , pp. 65-72
    • Barkai, I.A.1    Dunner, D.L.2    Gross, H.A.3    Mayo, P.4    Fieve, R.R.5
  • 7
    • 0028097856 scopus 로고
    • + as secondary, selective, consequences of inositol depletion in 1321N1 cells
    • + as secondary, selective, consequences of inositol depletion in 1321N1 cells. Biochem J. 297:1994;529-537.
    • (1994) Biochem J , vol.297 , pp. 529-537
    • Batty, I.H.1    Downes, C.P.2
  • 9
    • 0014495274 scopus 로고
    • Distribution and properties of CDP-diglyceride:inositol transferase from brain
    • Benjamins J.A., Agranoff B.W. Distribution and properties of CDP-diglyceride:inositol transferase from brain. J Neurochem. 16:1969;513-527.
    • (1969) J Neurochem , vol.16 , pp. 513-527
    • Benjamins, J.A.1    Agranoff, B.W.2
  • 11
    • 0024580756 scopus 로고
    • Lithium-induced teratogenesis in frog embryos prevented by a polyphosphoinositide cycle intermediate or a diacylglycerol analog
    • Busa W.B., Gimlich R.L. Lithium-induced teratogenesis in frog embryos prevented by a polyphosphoinositide cycle intermediate or a diacylglycerol analog. Dev Biol. 132:1989;315-324.
    • (1989) Dev Biol , vol.132 , pp. 315-324
    • Busa, W.B.1    Gimlich, R.L.2
  • 12
    • 0029036333 scopus 로고
    • Abnormal frontal lobe phosphorus metabolism in bipolar disorder
    • Deicken R.F., Fein G., Weiner M.W. Abnormal frontal lobe phosphorus metabolism in bipolar disorder. Am J Psychiatr. 152:1995;915-918.
    • (1995) Am J Psychiatr , vol.152 , pp. 915-918
    • Deicken, R.F.1    Fein, G.2    Weiner, M.W.3
  • 13
    • 0026498609 scopus 로고
    • 3H]inositol radioactivity and mass of second messenger inositol 1,4,5-triphosphate in monkey cerebral cortex slices
    • 3H]inositol radioactivity and mass of second messenger inositol 1,4,5-triphosphate in monkey cerebral cortex slices. J Neurochem. 59:1992;2332-2335.
    • (1992) J Neurochem , vol.59 , pp. 2332-2335
    • Dixon, J.F.1    Los, G.V.2    Hokin, L.E.3
  • 14
    • 0018791650 scopus 로고
    • 2+ flux in blowfly salivary glands
    • 2+ flux in blowfly salivary glands. Biochem J. 180:1979;661-665.
    • (1979) Biochem J , vol.180 , pp. 661-665
    • Fain, J.N.1    Berridge, M.J.2
  • 15
    • 0021995182 scopus 로고
    • Purification of phosphatidylinositol synthetase from rat brain by CDP-diacylglycerol affinity chromatography and properties of the purified enzyme
    • Ghalayini A., Eichberg J. Purification of phosphatidylinositol synthetase from rat brain by CDP-diacylglycerol affinity chromatography and properties of the purified enzyme. J Neurochem. 44:1985;175-182.
    • (1985) J Neurochem , vol.44 , pp. 175-182
    • Ghalayini, A.1    Eichberg, J.2
  • 16
    • 0024507366 scopus 로고
    • Potentiation by lithium of CMP-phosphatidate formation in carbachol-stimulated rat cerebral-cortical slices and its reversal by myo-inositol
    • Godfrey P.P. Potentiation by lithium of CMP-phosphatidate formation in carbachol-stimulated rat cerebral-cortical slices and its reversal by myo-inositol. Biochem J. 258:1989;621-624.
    • (1989) Biochem J , vol.258 , pp. 621-624
    • Godfrey, P.P.1
  • 18
    • 0019127799 scopus 로고
    • The effect of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain
    • Hallcher L.M., Sherman W.R. The effect of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain. J Biol Chem. 255:1980;10896-10901.
    • (1980) J Biol Chem , vol.255 , pp. 10896-10901
    • Hallcher, L.M.1    Sherman, W.R.2
  • 19
    • 0021921539 scopus 로고
    • Patients dying after long terminal phase have acidotic brains: Implications for biochemical measurements on autopsy tissue
    • Hardy J.A., Wester P., Winblad B., Gezelius C., Bring G., Eriksson A. Patients dying after long terminal phase have acidotic brains. Implications for biochemical measurements on autopsy tissue J Neural Transm. 61:1985;253-264.
    • (1985) J Neural Transm , vol.61 , pp. 253-264
    • Hardy, J.A.1    Wester, P.2    Winblad, B.3    Gezelius, C.4    Bring, G.5    Eriksson, A.6
  • 20
    • 0028037077 scopus 로고
    • Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy
    • Haussinger D., Laubenberger J., Dahl V., Ernst T., Bayer S., Langer M., Gerok W., Hennig J. Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. Gastroenterology. 107:1994;1475-1480.
    • (1994) Gastroenterology , vol.107 , pp. 1475-1480
    • Haussinger, D.1    Laubenberger, J.2    Dahl, V.3    Ernst, T.4    Bayer, S.5    Langer, M.6    Gerok, W.7    Hennig, J.8
  • 21
    • 0025936226 scopus 로고
    • Lithium-induced decrease of brain inositol and increase of brain inositol-1-phosphate is transient
    • Hirvonen M.R., Savolainen K. Lithium-induced decrease of brain inositol and increase of brain inositol-1-phosphate is transient. Neurochem Res. 16:1991;905-911.
    • (1991) Neurochem Res , vol.16 , pp. 905-911
    • Hirvonen, M.R.1    Savolainen, K.2
  • 22
    • 0020596356 scopus 로고
    • Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats
    • Honchar M.P., Olney J.W., Sherman W.R. Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. Science. 220:1983;323-325.
    • (1983) Science , vol.220 , pp. 323-325
    • Honchar, M.P.1    Olney, J.W.2    Sherman, W.R.3
  • 23
    • 0024363071 scopus 로고
    • Chronically administered lithium alters neither myo-inositol monophosphatase activity nor phosphoinositide levels in rat brain
    • Honchar M.P., Ackerman K.E., Sherman W.R. Chronically administered lithium alters neither myo-inositol monophosphatase activity nor phosphoinositide levels in rat brain. J Neurochem. 53:1989;590-594.
    • (1989) J Neurochem , vol.53 , pp. 590-594
    • Honchar, M.P.1    Ackerman, K.E.2    Sherman, W.R.3
  • 25
    • 0028219225 scopus 로고
    • Lithium and brain signal transduction systems
    • Jope R.S., Williams M.B. Lithium and brain signal transduction systems. Biochem Pharmacol. 47:1994;429-441.
    • (1994) Biochem Pharmacol , vol.47 , pp. 429-441
    • Jope, R.S.1    Williams, M.B.2
  • 26
    • 0025696264 scopus 로고
    • Inhibition by antibiotic tetracyclines of rat cortical noradrenergic adenylate cyclase and amphetamine-induced hyperactivity
    • Kofman O., Klein E., Newman M., Hamburger R., Kimche O., Nir T., Shimon H., Belmaker R.H. Inhibition by antibiotic tetracyclines of rat cortical noradrenergic adenylate cyclase and amphetamine-induced hyperactivity. Pharmacol Biochem Behav. 37:1990;417-424.
    • (1990) Pharmacol Biochem Behav , vol.37 , pp. 417-424
    • Kofman, O.1    Klein, E.2    Newman, M.3    Hamburger, R.4    Kimche, O.5    Nir, T.6    Shimon, H.7    Belmaker, R.H.8
  • 27
    • 0027722019 scopus 로고
    • Biochemical, behavioral, and clinical studies of the role of inositol in lithium treatment and depression
    • Kofman O., Belmaker R.H. Biochemical, behavioral, and clinical studies of the role of inositol in lithium treatment and depression. Biol Psychiatr. 34:1993;839-852.
    • (1993) Biol Psychiatr , vol.34 , pp. 839-852
    • Kofman, O.1    Belmaker, R.H.2
  • 28
    • 0027448447 scopus 로고
    • Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures
    • Kofman O., Sherman W.R., Katz V., Belmaker R.H. Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures. Psychopharmacology. 110:1993;229-234.
    • (1993) Psychopharmacology , vol.110 , pp. 229-234
    • Kofman, O.1    Sherman, W.R.2    Katz, V.3    Belmaker, R.H.4
  • 29
    • 0026773392 scopus 로고
    • Cerebral metabolic disturbances in patients with subacute and chronic diabetes mellitus: Detection with proton MR spectroscopy
    • Kreis R., Moss B.D. Cerebral metabolic disturbances in patients with subacute and chronic diabetes mellitus. detection with proton MR spectroscopy Radiology. 184:1992;123-130.
    • (1992) Radiology , vol.184 , pp. 123-130
    • Kreis, R.1    Moss, B.D.2
  • 32
    • 0025880361 scopus 로고
    • Interaction of trans and cis regulatory elements in the IN01 promoter of Saccharomyces cerevisaae
    • Lopes J.M., Henry S.A. Interaction of trans and cis regulatory elements in the IN01 promoter of Saccharomyces cerevisaae. Nuc Acids Res. 14:1991;3987-3994.
    • (1991) Nuc Acids Res , vol.14 , pp. 3987-3994
    • Lopes, J.M.1    Henry, S.A.2
  • 34
    • 0031225466 scopus 로고    scopus 로고
    • Lithium-induced inositol depletion in rat brain after chronic treatment is restricted to the hypothalamus
    • Lubrich B., Patishi Y., Kofman O., Agam G., Berger M., Belmaker R.H., van Calker D. Lithium-induced inositol depletion in rat brain after chronic treatment is restricted to the hypothalamus. Mol Psychiatr. 2:1997;407-412.
    • (1997) Mol Psychiatr , vol.2 , pp. 407-412
    • Lubrich, B.1    Patishi, Y.2    Kofman, O.3    Agam, G.4    Berger, M.5    Belmaker, R.H.6    Van Calker, D.7
  • 35
    • 0026686698 scopus 로고
    • A neurophysiological study of a lithium-sensitive phosphoinositide system in the hamster suprachiasmatic (Scn) biological clock in vitro
    • Mason R., Biello S.M. A neurophysiological study of a lithium-sensitive phosphoinositide system in the hamster suprachiasmatic (Scn) biological clock in vitro. Neurosci Lett. 144:1992;135-138.
    • (1992) Neurosci Lett , vol.144 , pp. 135-138
    • Mason, R.1    Biello, S.M.2
  • 36
    • 0027322890 scopus 로고
    • Alzheimer disease: Depiction of increased cerebral myo-inositol with proton MR spectroscopy
    • Miller B.L., Moats R.A., Shonk T., Ernst T., Woolley S., Ross B.D. Alzheimer disease. Depiction of increased cerebral myo-inositol with proton MR spectroscopy Radiology. 187:1993;433-437.
    • (1993) Radiology , vol.187 , pp. 433-437
    • Miller, B.L.1    Moats, R.A.2    Shonk, T.3    Ernst, T.4    Woolley, S.5    Ross, B.D.6
  • 37
    • 0025321883 scopus 로고
    • Inositol-1-phosphatase in RBC of manic-depressive patients before and during treatment with lithium
    • Moscovich D., Belmaker R.H., Agam G., Livne A. Inositol-1-phosphatase in RBC of manic-depressive patients before and during treatment with lithium. Biol Psychiat. 27:1990;552-555.
    • (1990) Biol Psychiat , vol.27 , pp. 552-555
    • Moscovich, D.1    Belmaker, R.H.2    Agam, G.3    Livne, A.4
  • 38
    • 0017359947 scopus 로고
    • Monoamine oxidase in chronic schizophrenia: Studies of hormonal and other factors affecting enzyme activity
    • Murphy D.L., Belmaker R.H., Carpenter W.T., Wyatt R.J. Monoamine oxidase in chronic schizophrenia. Studies of hormonal and other factors affecting enzyme activity Brit J Psychiat. 130:1977;151-158.
    • (1977) Brit J Psychiat , vol.130 , pp. 151-158
    • Murphy, D.L.1    Belmaker, R.H.2    Carpenter, W.T.3    Wyatt, R.J.4
  • 39
    • 0025912111 scopus 로고
    • Lithium and the phosphoinositide cycle: An example of uncompetitive inhibition and its pharmacological consequences
    • Nahorski S.R., Ragan C.I., Challiss R.A. Lithium and the phosphoinositide cycle. An example of uncompetitive inhibition and its pharmacological consequences Trends Pharmacol Sci. 12:1991;297-303.
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 297-303
    • Nahorski, S.R.1    Ragan, C.I.2    Challiss, R.A.3
  • 40
    • 0026451081 scopus 로고
    • Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
    • Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science. 258:1992;607-614.
    • (1992) Science , vol.258 , pp. 607-614
    • Nishizuka, Y.1
  • 41
    • 0023784340 scopus 로고
    • Are post-mortem biochemical studies of human brain worthwhile?
    • Palmer A.M., Lowe S.L., Francis P.T., Bowen D.M. Are post-mortem biochemical studies of human brain worthwhile? Biochem Soc Trans. 16:1988;472-475.
    • (1988) Biochem Soc Trans , vol.16 , pp. 472-475
    • Palmer, A.M.1    Lowe, S.L.2    Francis, P.T.3    Bowen, D.M.4
  • 42
    • 0023808367 scopus 로고
    • Susceptibility to pilocarpine-induced seizures in rats increases with age
    • Patel S., Meldrum B.S., Fine A. Susceptibility to pilocarpine-induced seizures in rats increases with age. Behav Brain Res. 31:1988;165-167.
    • (1988) Behav Brain Res , vol.31 , pp. 165-167
    • Patel, S.1    Meldrum, B.S.2    Fine, A.3
  • 43
    • 0030273350 scopus 로고    scopus 로고
    • Effect of age, sex, steroids, brain region, and genetic strain on brain inositol monophosphatase activity
    • a
    • Patishi Y., Belmaker R.H., Agam G. Effect of age, sex, steroids, brain region, and genetic strain on brain inositol monophosphatase activity. Biol Psychiat. 40:1996;656-659. a.
    • (1996) Biol Psychiat , vol.40 , pp. 656-659
    • Patishi, Y.1    Belmaker, R.H.2    Agam, G.3
  • 44
    • 0029887001 scopus 로고    scopus 로고
    • A comparison of the ability of myo-inositol and epi-inositol to attenuate lithium-pilocarpine seizures in rats
    • b
    • Patishi Y., Belmaker R.H., Bersudsky Y., Kofman O. A comparison of the ability of myo-inositol and epi-inositol to attenuate lithium-pilocarpine seizures in rats. Biol Psychiat. 39:1996;829-832. b.
    • (1996) Biol Psychiat , vol.39 , pp. 829-832
    • Patishi, Y.1    Belmaker, R.H.2    Bersudsky, Y.3    Kofman, O.4
  • 46
    • 0027721890 scopus 로고
    • 2) receptor induced homologous and heterologous desensitization
    • 2) receptor induced homologous and heterologous desensitization. Brain Res. 631:1993;349-351.
    • (1993) Brain Res , vol.631 , pp. 349-351
    • Rahman, S.1    Neuman, R.S.2
  • 47
    • 0029800675 scopus 로고    scopus 로고
    • Epi-inositol is biochemically active in reversing lithium effects on cytidine monophosphorylphosphatidate (Cmp-pa)
    • Richards M.H., Belmaker R.H. Epi-inositol is biochemically active in reversing lithium effects on cytidine monophosphorylphosphatidate (Cmp-pa). J Neural Transm. 103:1996;1281-1285.
    • (1996) J Neural Transm , vol.103 , pp. 1281-1285
    • Richards, M.H.1    Belmaker, R.H.2
  • 48
    • 0026529044 scopus 로고
    • Coordinate genetic control of yeast fatty acid synthase genes Fas1 and Fas2 by an upstream activation site common to genes involved in membrane lipid biosynthesis
    • Schuller J.H., Hahn A., Troster F., Schutz A., Schweizer E. Coordinate genetic control of yeast fatty acid synthase genes Fas1 and Fas2 by an upstream activation site common to genes involved in membrane lipid biosynthesis. EMBO J. 11:1992;107-114.
    • (1992) EMBO J , vol.11 , pp. 107-114
    • Schuller, J.H.1    Hahn, A.2    Troster, F.3    Schutz, A.4    Schweizer, E.5
  • 49
    • 0019831422 scopus 로고
    • Evidence that lithium alters phosphoinositide metabolism: Chronic administration elevates primarily D-myo-inositol-1-phosphate in cerebral cortex of the rat
    • Sherman W.R., Leavitt A.L., Honchar M.P., Hallcher L.M., Phillips B.E. Evidence that lithium alters phosphoinositide metabolism. Chronic administration elevates primarily D-myo-inositol-1-phosphate in cerebral cortex of the rat J Neurochem. 36:1981;1947-1951.
    • (1981) J Neurochem , vol.36 , pp. 1947-1951
    • Sherman, W.R.1    Leavitt, A.L.2    Honchar, M.P.3    Hallcher, L.M.4    Phillips, B.E.5
  • 50
    • 0001782355 scopus 로고
    • Detection of receptor-linked phophoinositide metabolism in brian of lithium-treated rats
    • J.E. Bleasdale, J. Eichborg, & C. Hauser. Clifton NJ: Humana Press. a
    • Sherman W.R., Honchar M.P., Munsell L.Y. Detection of receptor-linked phophoinositide metabolism in brian of lithium-treated rats. Bleasdale J.E., Eichborg J., Hauser C. Inositol and Phosphoinositides. Metabolism and Regulation:1985;49-65 Humana Press, Clifton NJ. a.
    • (1985) Inositol and Phosphoinositides: Metabolism and Regulation , pp. 49-65
    • Sherman, W.R.1    Honchar, M.P.2    Munsell, L.Y.3
  • 51
    • 0021940076 scopus 로고
    • Effects of systemically administered lithium on phosphoinositide metabolism in rat brain, kidney and testis
    • b
    • Sherman W.R., Munsell L.Y., Gish B.G., Honchar M.P. Effects of systemically administered lithium on phosphoinositide metabolism in rat brain, kidney and testis. J Neurochem. 44:1985;798-807. b.
    • (1985) J Neurochem , vol.44 , pp. 798-807
    • Sherman, W.R.1    Munsell, L.Y.2    Gish, B.G.3    Honchar, M.P.4
  • 52
    • 0023039173 scopus 로고
    • Effects of lithium on phoshoinositide metabolism in vivo
    • Sherman W.R., Gish B.G., Honchar M.P., Munsell L.Y. Effects of lithium on phoshoinositide metabolism in vivo. Fed Proc. 45:1986;2639-2646.
    • (1986) Fed Proc , vol.45 , pp. 2639-2646
    • Sherman, W.R.1    Gish, B.G.2    Honchar, M.P.3    Munsell, L.Y.4
  • 53
    • 0002967375 scopus 로고
    • Lithium and the phosphoinositide signalling system
    • N.J. Birch. London: Academic Press
    • Sherman W.R. Lithium and the phosphoinositide signalling system. Birch N.J. Lithium and the Cell. Pharmacology and Biochemistry:1991;121-157 Academic Press, London.
    • (1991) Lithium and the Cell: Pharmacology and Biochemistry , pp. 121-157
    • Sherman, W.R.1
  • 54
    • 0030877331 scopus 로고    scopus 로고
    • Reduced inositol levels in frontal cortex of post-mortem brain from bipolar patients and suicides
    • Shimon H., Agam G., Belmaker R.H., Hyde T., Kleinman J.E. Reduced inositol levels in frontal cortex of post-mortem brain from bipolar patients and suicides. Am J Psychiatry. 154:1997;1148-1150.
    • (1997) Am J Psychiatry , vol.154 , pp. 1148-1150
    • Shimon, H.1    Agam, G.2    Belmaker, R.H.3    Hyde, T.4    Kleinman, J.E.5
  • 55
    • 0023789039 scopus 로고
    • Myo-inositol transport through the blood-brain barrier
    • Spector R., Lorenzo A.V. Myo-inositol transport through the blood-brain barrier. Neurochem Res. 13:1975;785-787.
    • (1975) Neurochem Res , vol.13 , pp. 785-787
    • Spector, R.1    Lorenzo, A.V.2
  • 56
    • 3342922088 scopus 로고
    • A microcolorimetric method for the determination of inorganic phosphorus
    • Taussky H., Shorr E., Kurzmann G.A. A microcolorimetric method for the determination of inorganic phosphorus. J Biol Chem. 20:1953;675-681.
    • (1953) J Biol Chem , vol.20 , pp. 675-681
    • Taussky, H.1    Shorr, E.2    Kurzmann, G.A.3
  • 57
    • 0024459094 scopus 로고
    • Myo-inositol: A newly identified nonnitrogenous osmoregulatory molecule in mammalian brain
    • Thurston J.H., Sherman W.R., Hauhart R.E., Kloepper R.F. Myo-inositol. A newly identified nonnitrogenous osmoregulatory molecule in mammalian brain Pediatr Res. 26:1989;482-485.
    • (1989) Pediatr Res , vol.26 , pp. 482-485
    • Thurston, J.H.1    Sherman, W.R.2    Hauhart, R.E.3    Kloepper, R.F.4
  • 58
    • 0025916245 scopus 로고
    • Evidence that a proconvulsant action of lithium is mediated by inhibition of myo-inositol phosphatase in mouse brain
    • Tricklebank M.D., Singh L., Oles R.J. Evidence that a proconvulsant action of lithium is mediated by inhibition of myo-inositol phosphatase in mouse brain. Brain Res. 558:1991;145-148.
    • (1991) Brain Res , vol.558 , pp. 145-148
    • Tricklebank, M.D.1    Singh, L.2    Oles, R.J.3
  • 59
    • 0024318504 scopus 로고
    • Effects of lithium on inositol phospholipid hydrolysis and inhibition of dopamine D1 receptor-mediated cyclic AMP formation by carbachol in rat brain slices
    • Whitworth P., Kendall D.A. Effects of lithium on inositol phospholipid hydrolysis and inhibition of dopamine D1 receptor-mediated cyclic AMP formation by carbachol in rat brain slices. J Neurochem. 53:1989;536-541.
    • (1989) J Neurochem , vol.53 , pp. 536-541
    • Whitworth, P.1    Kendall, D.A.2
  • 60
    • 0029057554 scopus 로고
    • Modulation by inositol of cholinergic- And serotonergic-induced seizures in lithium treated rats
    • Williams M.B., Jope R.S. Modulation by inositol of cholinergic- and serotonergic-induced seizures in lithium treated rats. Brain Res. 685:1995;169-178.
    • (1995) Brain Res , vol.685 , pp. 169-178
    • Williams, M.B.1    Jope, R.S.2
  • 61
    • 0023247347 scopus 로고
    • A review of the biochemical and neuropharmacological actions of lithium
    • Wood A.J., Goodwin G.M. A review of the biochemical and neuropharmacological actions of lithium. Psychol Med. 17:1987;579-600.
    • (1987) Psychol Med , vol.17 , pp. 579-600
    • Wood, A.J.1    Goodwin, G.M.2


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