High levels of BCL-2 messenger RNA detected by in situ hybridization in human hepatocellular and cholangiocellular carcinomas

Diagnostic Molecular Pathology

Volumn 8, Issue 4, 1999, Pages 189-194

  Fiorentino, Michelangelo ^a   D'Errico, Antonia ^a   Altimari, Annalisa ^a   Barozzi, Chiara ^a   Grigioni, Walter Franco ^a,b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Bcl 2; Cholangiocarcinoma; Cytokeratins; Hepatocellular carcinoma; In situ hybridization

Indexed keywords

CYTOKERATIN; MESSENGER RNA; PROTEIN BCL 2;

ARTICLE; BILE DUCT CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; LIVER BIOPSY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN DETERMINATION;

BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CARCINOMA, HEPATOCELLULAR; CHOLANGIOCARCINOMA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION; KERATINS; LIVER NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER;

EID: 0033431018     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019606-199912000-00004     Document Type: Article

References (23)

1. Charlotte F, L'Herminè A, Martin N, Geleyn Y, Nollet M, Gaulard P, Zafrani ES. Immunohistochemical detection of Bcl-2 protein in normal and pathological human liver. Am J Pathol 1994;144: 460-5.
2. Craig JR, Peters RL, Edmondson HA. Tumors of the liver and intrahepatic bile ducts. Washington, Armed Force Institute of Pathology (A.F.I.P) atlas, 1988.
3. D'Errico A, Baccarini P, Fiorentino M, Ceccarelli C, Bonazzi C, Ponzetto A, Scoazec JY, Mancini AM, Grigioni WF. Histogenesis of liver primary carcinoma. Pittfalls of cytokeratin profile and albumin mRNA detection. Hum Pathol 1996;27:599-604.
4. Fiorentino M, D'Errico A, Barozzi C, Grigioni WF. Discrepancies between detection of bcl-2 mRNA by in situ hybridization and bcl-2 protein by immunocytochemistry in human prostate cancer tissues. Int J Cancer 1998;79:614-9.
5. Frommel TO, Yong S, Zarling EJ. Immunohistochemical evaluation of bcl-2 gene family expression in liver of hepatitis C and cirrhotic patients: a novel mechanism to explain the high incidence of hepatocarcinoma in cirrhotics. Am J Gastroenterol 1999;94: 178-82.
6. Goodman ZD, Ishak KG, Langloss JM, Sesterhenn IA, Rabin L. Combined hepatocellular-cholangiocarcinomas: a histologic and immunohistochemical study. Cancer 1985;55:124-35.
7. Harada K, Kono N, Tsuneyama K, Nakanuma Y. Cell-kinetic study of proliferating bile-duct cells in various hepatobiliary diseases. Liver 1998;18:277-84.
8. Harigai M, Miyashita T, Hanada T, Reed JC. A cis-acting element in the bcl-2 gene controls expression trough translational mechanisms. Oncogene 1996;12:1369-74.
9. Korsmeyer SJ. Programmed cell death: bcl-2. In: Important advances in oncology. Philadelphia: Lippincott, 1993;19-28.
10. Kurosawa H, Que FG, Roberts LR, Fesmier PJ, Gores GJ. Hepatocytes in the bile duct-ligated rat express Bcl-2. Am J Physiol 1997;272:G1587-93.
11. Lee GH. Correlation between Bcl-2 expression and histopathology in Diethylnitrosamine-induced mouse hepatocellular tumors. Am J Pathol 1997;151:957-61.
12. Lu QL, Abel P, Foster C, Lalani EN. Bcl-2: role in epithelial differentiation and oncogenesis. Hum Pathol 1996;27:102-10.
13. Nakanuma Y, Ohta G. Immunohistochemical study on bile ductular proliferation in various hepatobiliary diseases. Liver 1986;6: 205-11.
14. Nakopoulou L, Stefanaki K, Vourlakou C, Manolaki N, Gakiopoulou H, Michalopoulos G. Bcl-2 protein expression in acute and chronic hepatitis, cirrhosis and hepatocellular carcinoma. Pathol Res Pract 1999;195:19-24.
15. Skopelitou A, Hadjiyannakis M, Alexopoulou V, Krikoni O, Kamina S, Agnantis N. Topographical immunoistochemical expression of bcl-2 protein in human liver lesions. Anticancer Res 1996; 16:975-8.
16. Soini Y, Virkajarvi, Lehto VP, Paakko P. Hepatocellular carcinomas with a high proliferation index and a low degree of apoptosis and necrosis are associated with a shortened survival. Br J Cancer 1996;73:1025-30.
17. Terada T, Nakanuma Y. Detection of apoptosis and expression of apoptosis-related proteins during human intrahepatic bile duct development. Am J Pathol 1995;146:67-74.
18. Tsujimoto Y, Croce CM. Analysis of the structure, transcripts and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Nat Acad Sci 1986;83:5214-8.
19. Van Eyken P, Sciot R, Paterson A, Callea F, Kew MC, Desmet VJ. Cytokeratin expression in hepatocellular carcinoma: an immunoistochemical study. Hum Pathol 1988;19:562-8.
20. Wu PC, Wing-Sang Fang J, Ka-Tai Lau V, Lai CL, Lo CK, Yiu-Nam Lau J. Classification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers. Am J Pathol 1996;149:1167-75.
21. Young RL, Korsmeyer SJ. A negative regulatory element in the bcl-2 5'-untranslated region inhibits expression from an upstream promoter. Mol Cell Biol 1993;13:3686-97.
22. Zeppa P, Benincasa G, Fulciniti F, Cochand Priollet B, Troncone G, Vetrani A, Celentano E, Nardone G, Palombini L. Apoptosis and cytologic differentiation in hepatocellular carcinoma on fine needle aspiration samples. Acta Cytol 1996;40:861-6.
23. Zhao M, Zhang NX, Economou M, Blaha I, Laissue JA, Zimmermann A. Immunoistochemical detection of bcl-2 protein in liver lesions: bcl-2 protein is expressed in hepatocellular carcinomas but not in liver cell dysplasia. Histopathology 1994; 25: 237-45.