Preliminary study of real-time fiber optic based protein C biosensor

Biotechnology and Bioengineering

Volumn 66, Issue 3, 1999, Pages 158-163

  Spiker, James O ^a   Kang, Kyung A ^a  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

Author keywords

Anticoagulant; Biosensor; Fiber optics; Immuno optical detection; Protein C

Indexed keywords

BIOASSAY; ENZYME IMMOBILIZATION; FIBER OPTIC CHEMICAL SENSORS; FLUORESCENCE; MONOCLONAL ANTIBODIES;

ANTICOAGULANTS;

IMMUNOSENSORS;

ANTICOAGULANT AGENT; AVIDIN; BIOTIN; MONOCLONAL ANTIBODY; PROTEIN C;

ANALYZER; ARTICLE; AUTOMATION; BIOSENSOR; FIBER OPTICS; FLUOROMETRY; HUMAN; IMMOBILIZATION; PROTEIN C DEFICIENCY;

ANIMALS; ANTIBODIES, MONOCLONAL; AVIDIN; BIOSENSING TECHNIQUES; BIOTECHNOLOGY; BIOTIN; BUFFERS; EVALUATION STUDIES; FIBER OPTICS; HUMANS; MICE; PROTEIN C; PROTEIN C DEFICIENCY;

EID: 0033430940     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(1999)66:3<158::AID-BIT3>3.0.CO;2-G     Document Type: Article

References (16)

1. Bertina RM. 1988. Assays for protein C. In: Bertina RM, editor. Protein C and Related Proteins. Edinburgh: Churchill Livingstone. p 130-150.
2. Bhatia SK, Shriver-Lake LC, Prior KJ, Georger JH, Calvert JM, Bredehorst R. Ligler FS. 1989. Use of thiol-terminal silanes and heterobifunctional cross-linkers for immobilization of antibodies on silica surfaces. Anal Biochem 178:408-413.
3. Breslin K, Anderson G, Shriver-Lake L, Liger F. 1994. Regeneration of immobilized antibodies on fiber optic probes. Biosens Bioelectron 9:585-592.
4. Esmon C. 1990. Regulation of Coagulation: The Nature of the Problem. In: Bruley DF, Drohan WN. editors. Protein C and Related Anticoagulants. Houston: Gulf Publishing Company. p 3-10.
5. Esmon C, Schwarz HP. 1995. An update on clinical and basic aspects of the protein C anticoagulant pathway. Trends Cardiovasc Med 5: 141-148.
6. Haas F, van Sterkenburg-Kamp B, Scheepers H. 1998. A protein C pathway (PCP) screening test for the detection of APC resistance and protein C or S deficiencies. Semin Thromb Hemostasis 24(4):355-362.
7. Kang KA, Anis N, Eldefrawi M, Drohan WN, Bruley DF. 1997. Reusable, real-time, immuno-optical protein C biosensor. Adv Exp Med Biol 411:437-444.
8. Ligler FS, Golden JP, Shriver-Lake LC, Ogert RA, Wijesuria D, Anderson GP. 1993. Fiber-optic biosensor for the detection of hazardous materials. Immunomethods 3:122-127.
9. Marlar RA, Adcock DM. 1990. Protein C replacement therapy as a treatment modality for homozygous protein C deficiency. In: Bruley DF, Drohan WN, editors. Protein C and related anticoagulants. Houston: Gulf Publishing Company. p 165-178.
10. Narang U, Anderson GP, Ligler FS, Burans J. 1997. Fiber optic-based biosensor for ricin. Biosens Bioelectron 9-10:937-945.
11. Reltsma PH. 1997. Protein C deficiency: From gene defects to disease. Thromb Hemostasis 78:344-350.
12. Research International. 1995. Analyte 2000 User Guide.
13. Rogers KR, Fernando JC, Thompson RG, Valdes JJ, Eldefrawi ME. 1992. Detection of nicotinic receptor ligands with a light addressable potentiometric sensor. Anal Biochem 202(1):111-116.
14. Rowe CA, Bolitho JS, Jane A, Bundesen PG, Rylatt DB, Eisenberg PR, Ligler FS. 1998. Rapid detection of D-dimer using a fiber optic biosensor. Thromb Hemostasis 79:94-98.
15. Spiker JO, Kang KA, Drohan WN, Bruley DF. 1998. Preliminary study of biosensor optimization for the detection of protein C. Adv Exp Med Biol 454:681-688.
16. Velander WH, Morcol T, Clark DB, Gee D, Drohan WN. 1990. Technological Challenges for Large-Scale Purification of Protein C. In: Bruley DF, Drohan WN, editors. Protein C and related anticoagulants. Houston: Gulf Publishing Company. p 11-27.