Abl expression, tumour grade, and apoptosis in chondrosarcoma

Journal of Clinical Pathology - Molecular Pathology

Volumn 52, Issue 6, 1999, Pages 341-344

  O'Donovan, M ^a   Russell, J M ^a   O'Leary, J J ^c   Gillan, J A ^b   Lawler, M P ^d   Gaffney, E F ^a  

^a ST JAMES S HOSPITAL   (Ireland)

^b ROTUNDA HOSPITAL   (Ireland)

^c Pathology Research Laboratory   (Ireland)

^d TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Abl gene expression; Apoptosis; Chondrosarcoma

Indexed keywords

APOPTOSIS; ARTICLE; CANCER GRADING; CHONDROSARCOMA; HUMAN; HUMAN TISSUE; MITOSIS INDEX; ONCOGENE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION;

EID: 0033405159     PISSN: 13668714     EISSN: None     Source Type: Journal    
DOI: 10.1136/mp.52.6.341     Document Type: Article

References (28)

1. Wang JYJ. Abl tyrosine kinase in signal transduction and cell-cycle regulation. Curr Opin Genet Dev 1993;3:35-43.
2. Sawyers CL, McLaughlin J, Goga A, et al. The nuclear tyrosine kinase c-Abl negatively regulates cell growth. Cell 1994;77:121-31.
3. Mc Gahon AJ, Cotter TG, Green DR. The abl oncogene family and apoptosis. Cell Death and Differentiation 1994;1: 77-83.
4. Bedi A, Zehnbauer BA, Barber JP, et al. Inhibition of apoptosis by BCR ABL in chronic myeloid leukaemia. Blood 1994;83:2038-44.
5. Taagepera S, McDonald D, Loeb JE, et al. Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. Proc Natl Acad Sci USA 1998;95:7457-62.
6. Wen S-T, Jackson PK, Van Etten RA. The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products. EMBO J 1996;15:1583-95.
7. Daniel R, Wong PMC, Chung S-W. Isoform-specific functions of c-abl: type I is necessary for differentiation, and type II is inhibitory to apoptosis. Cell Growth Differ 1996;7:1141-8.
8. Chung S-W, Daniel R, Wong BY, et al. The ABL genes in normal and abnormal cell development. Crit Rev Oncog 1996;7:33-48.
9. O'Neill AJ, Cotter TG, Russell JM, et al. Abl expression in human fetal and adult tissues, tumours and tumour microvessels. J Pathol 1997;183:325-9.
10. Bjornsson J, McLeod RA, Unni KK, et al. Primary chondrosarcoma of the long bones and limb girdles. Cancer 1998;83:2105-19.
11. Staunton MJ, Gaffney EF. Tumor type is a determinant of susceptibility to apoptosis. Am J Clin Pathol 1995;103:300-7.
12. Farnum CE, Wilsman NJ. Morphologic stages of the terminal hypertrophic chondrocyte of growth plate cartilage. Anat Rec 1987;219:221-32.
13. Farnum CE, Turgai J, Wilsman NJ. Visualization of living terminal hypertrophic chondrocytes of growth plate cartilage in situ by differential interference contrast microscopy and time-lapse cinematography. J Orthop Res 1990;8:750-63.
14. Gibson G, Lin D-L, Roque M. Apoptosis of terminally differentiated chondrocytes in culture. Exp Cell Res 1997;233: 372-82.
15. Zenmyo M, Komiya S, Kawabata R, et al. Morphological and biochemical evidence for apoptosis in the terminal hypertrophic chondrocytes of the growth plate. J Pathol 1996;180:430-3.
16. Gibson GJ, Kohler WJ, Schaffler MB. Chondrocyte apoptosis in endochondral ossification of chick sterna. Dev Dyn 1995;203:468-70.
17. Enomoto-Iwamoto M, Iwamoto M, Mukudai Y, et al. Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytes. J Cell Biol 1998;140: 409-18.
18. Roach HI, Erenpresia J, Aigner T. Osteogenic differentiation of hypertrophic chondrocytes involves asymmetric cell divisions and apoptosis. J Cell Biol 1995;131:483-94.
19. Kameda T, Watanabe, Iba H. C-Jun and JunD suppress maturation of chondrocytes. Cell Growth Differ 1997;8: 495-503.
20. Yang C, Li S-W, Helminen HJ, et al. Apoptosis of chondrocytes in transgenic mice lacking collagen II. Exp Cell Res 1997;235:370-3.
21. Kennedy MM, Lucas SB, Russell-Jones R, et al. HHV8 and female Kaposi's sarcoma. J Pathol 1997;183:447-52.
22. Staunton MJ, Gaffney EF. Apoptosis: basic concepts and potential significance in human cancer. Arch Pathol Lab Med 1998;122:310-19.
23. Leoncini L, Del Vecchio MT, Megha T, et al. Correlations between apoptotic and proliferative indices in malignant non-Hodgkin's lymphomas. Am J Pathol 1993;142:755-63.
24. Mc Menamin ME, O'Neill AJ, Gaffney EF. The extent of apoptosis in ovarian serous carcinoma in relationship to mitotic and proliferative indices, p53 expression and survival. J Clin Pathol: Mol Pathol 1997;50:242-6.
25. O'Neill AJ, Staunton MJ, Gaffney EF. Apoptosis occurs independently of bcl-2 and p53 over-expression in non-small cell lung carcinoma. Histopathology 1996;29:45-50.
26. Lipponen PK, Aaltomaa S. Apoptosis in bladder cancer as related to standard prognostic factors and prognosis. J Pathol 1994;173:333-9.
27. Evan G, Littlewood T. A matter of life and cell death. Science 1998;281:1317-22.
28. Hasegawa T, Seki K, Yang P, et al. Differentiation and proliferative activity in benign and malignant cartilaginous tumours of bone. Hum Pathol 1995;26:838-45.