Comparison of the intracellular trafficking of two alternatively spliced isoforms of pp120, a substrate of the insulin receptor tyrosine kinase

Journal of Cellular Biochemistry

Volumn 76, Issue 1, 2000, Pages 133-142

  Choice, Curtis V ^a   Poy, Matthew N ^a   Formisano, Pietro ^b   Najjar, Sonia M ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Assembly; Intracellular synthesis; Kinetics; Pulse chase; Receptor mediated endocytosis

Indexed keywords

INSULIN RECEPTOR KINASE; INSULIN RECEPTOR SUBSTRATE 1;

ALTERNATIVE RNA SPLICING; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL MATURATION; CELL STRAIN 3T3; ENDOCYTOSIS; GOLGI COMPLEX; INTRACELLULAR TRANSPORT; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; PROTEIN TRANSPORT;

EID: 0033405011     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(20000101)76:1<133::AID-JCB13>3.0.CO;2-B     Document Type: Article

References (34)

1. Bartles JR, Braiterman LT, Hubbard AL. 1985. Biochemical characterization of domain-specific glycoproteins of the rat hepatocyte plasma membrane. J Biol Chem 260: 12792-12802.
2. Bartles JR, Feracci HM, Stieger B, Hubbard AL. 1987. Biogenesis of the rat hepatocyte plasma membrane in vivo: comparison of the pathways taken by apical and basolateral proteins using subcellular fractionation. J Cell Biol 105:1241-1251.
3. Bosshart H, Humphrey J, Deignan E, Davidson J, Drazba J, Yuan L, Oorschot V, Peters PJ, Bonifacino JS. 1994. The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/ lysosomal system. J Cell Biol 126:1157-1172.
4. Casanova JE, Breitfeld PP, Ross SA, Mostov KE. 1990. Phosphorylation of the polymeric immunoglobulin receptor required for its efficient transcytosis. Science 248:742-745.
5. Cheung PH, Thompson NL, Earley K, Culic O, Hixson D, Lin SH. 1993. Cell-CAM 105 isoforms with different adhesion functions are coexpressed in adult rat tissues and during liver development. J Biol Chem 268:6139-6146.
6. Choice CV, Howard MJ, Poy MN, Hankin MH, Najjar SM. 1998. Insulin stimulates pp120 endocytosis in cells coexpressing insulin receptors. J Biol Chem 273:22194-22200.
7. Duronio V, Jacobs S, Cuatrecasas P. 1986. Complete glycosylation of the insulin and insulin-like growth factor I receptors is not necessary for their biosynthesis and function. Use of swainsonine as an inhibitor in IM-9 cells. J Biol Chem 261:970-975.
8. Edlund M, Öbrink B. 1993. Evidence for calmodulin binding to the cytoplasmic domains of two C-CAM isoforms. FEBS Lett 327:90-94.
9. Formisano P, Najjar SM, Gross CN, Philippe N, Oriente F, Kern-Buell CL, Accili D, Gorden P. 1995. Receptor-mediated internalization of insulin. Potential role of pp120/HA4, a substrate of the insulin receptor kinase. J Biol Chem 270:24073-24077.
10. Jui HY, Suzuki Y, Accili D, Taylor SI. 1994. Expression of a cDNA encoding the human insulin receptor-related receptor. J Biol Chem 269:22446-22452.
11. Hsieh J-T, Luo W, Song W, Wang Y, Kleinerman DI, Van NT, Lin S-H. 1995. Tumor suppressive role of an androgen-regulated epithelial cell adhesion molecule (C-CAM) in prostate carcinoma cell revealed by sense and antisense approaches. Cancer Res 55:190-197.
12. Hunter I, Lindh M, Öbrink B. 1994. Differential regulation of C-CAM isoforms in epithelial cells. J Cell Sci 107:1205-1216.
13. Le Gall AH, Powell SK, Yeaman CA, Rodriguez-Boulan E. 1997. The neural cell adhesion molecule expresses a tyrosine-independent basolateral sorting signal. J Biol Chem 272:4559-4567.
14. Li Calzi S, Choice CV, Najjar SM. 1997. Differential effect of pp120 on insulin internalization via the spliced isoforms of the receptor. Am J Physiol 273:E801-E806.
15. Lin S-H, Guidotti G. 1989. Cloning and expression of a cDNA coding for a rat liver plasma membrane ecto-ATPase. J Biol Chem 264:14408-14414.
16. Lin S-H, Luo W, Barley K, Cheung P, Hixson DC. 1995. Structure and function of C-CAM1: effects of the cytoplasmic domain on cell aggregation. Biochem J 311:239-245.
17. Luo W, Earley K, Tantingco V, Hixson DC, Liang TC, Lin S-H. 1998. Association of an 80 kDa protein with C-CAM1 cytoplasmic domain correlates with C-CAM1-mediated growth inhibition. Oncogene 16:1141-1147.
18. Margolis RN, Taylor SI, Seminara D, Hubbard AL. 1988. Identification of pp120, an endogenous substrate for the hepatocyte insulin receptor tyrosine kinase, as an integral membrane glycoprotein of the bile canalicular domain. Proc Natl Acad Sci USA 85:7256-7259.
19. Margolis RN, Schell MJ, Taylor SI, Hubbard AL. 1990. Hepatocyte plasma membrane ecto-ATPase (pp120/HA4) is a substrate for tyrosine kinase activity of the insulin receptor. Biochem Biophy Res Commun 166:562-566.
20. Matter K, Mellman I. 1994. Mechanisms of cell polarity: sorting and transport in epithelial cells. Curr Opin Cell Biol 6:545-554.
21. Monlauzeur L, Rajasekaran A, Chao M, Rodriguez-Boulan E, Le Bivic A. 1995. A cytoplasmic tyrosine is essential for the basolateral localization of mutants of the human nerve growth factor receptor in Madin-Darby canine kidney cells. J Biol Chem 270:12219-12225.
22. Najjar SM, Lewis RE. 1999. Persistent expression of foreign genes in cultured hepatocytes: expression vectors. Gene 230:41-45.
23. Najjar SM, Accili D, Philippe N, Jernberg J, Margolis R, Taylor SI. 1993. pp120/ecto-ATPase, an endogenous substrate of the insulin receptor tyrosine kinase, is expressed as two variably spliced isoforms. J Biol Chem 268:1201-1206.
24. Najjar SM, Philippe N, Suzuki Y, Ignacio GA, Formisano P, Accili D, Taylor SI. 1995. Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase. Biochemistry 34:9341-9349.
25. Najjar SM, Choice CV, Soni P, Whitman CM, Poy MN. 1998. Effect of pp120 on receptor-mediated insulin endocytosis is regulated by the juxtamembrane domain of the insulin receptor. J Biol Chem 273:12923-12928.
26. Nedellec P, Dveksler GS, Daniels E, Turbide C, Chow B, Basile AA, Holmes KV, Beauchemin N. 1994. Bgp2, a new member of the carcinoembryonic antigen-related gene family, encodes an alternative receptor for mouse hepatitis viruses. J Virology 68:4525-4537.
27. Perrotti N, Accili D, Marcus SB, Rees JR, Taylor SI. 1987. Insulin stimulates phosphorylation of a 120-kDa glycoprotein substrate (pp120) for the receptor-associated protein kinase in intact H-35 hepatoma cells. Proc Natl Acad Sci USA 84:3137-3140.
28. Pimplikar SW, Simons K. 1994. Activators of protein kinase A stimulate apical but not basolateral transport in epithelial Madin-Darby canine kidney cells. J Biol Chem 269: 19054-19059.
29. Rees-Jones RW, Taylor SI. 1985. An endogenous substrate for the insulin receptor-associated tyrosine kinase. J Biol Chem 260:4461-4467.
30. Rutledge EA, Gaston I, Root BJ, McGraw TE, Enns CA. 1998. The transferrin receptor cytoplasmic domain determines its rate of transport through the biosynthetic pathway and its susceptibility to cleavage early in the pathway. J Biol Chem 273:12169-12175.
31. Scott LJ, Hubbard AL. 1992. Dynamics of four rat liver plasma membrane proteins and polymeric IgA receptor. Rates of synthesis and selective loss into the bile. J Biol Chem 267:6099-6106.
32. Sippel CJ, Suchy FJ, Ananthanarayanan M, Perlmutter DH. 1993. The rat liver ecto-ATPase is also a canalicular bile acid transport protein. J Biol Chem 268:2083-2091.
33. Sippel CJ, Fallon RJ, Perlmutter DH. 1994. Bile acid efflux mediated by the rat liver canalicular bile acid transport/ ecto-ATPase protein requires serine 503 phosphorylation and is regulated by tyrosine 488 phosphorylation. J Biol Chem 269:19539-19545.
34. Yenush L, White MF. 1997. The IRS-signalling system during insulin and cytokine action. BioEssays 19:491-500.