Endoscopic treatments for portal hypertension

Seminars in Liver Disease

Volumn 19, Issue 4, 1999, Pages 439-455

  De Franchis, Roberto ^a   Primignani, Massimo ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Endoscopic treatment; Meta analysis; Variceal bleeding

Indexed keywords

OCTREOTIDE; SOMATOSTATIN; TERLIPRESSIN; THROMBIN; TISSUE ADHESIVE; VASOACTIVE AGENT;

ARTICLE; ENDOSCOPIC SCLEROTHERAPY; ENDOSCOPIC SURGERY; ESOPHAGUS VARICES BLEEDING; HUMAN; INTERMETHOD COMPARISON; PORTAL HYPERTENSION; PRIORITY JOURNAL; STOMACH VARICES; SURGICAL TECHNIQUE; TREATMENT CONTRAINDICATION; TREATMENT INDICATION; TREATMENT OUTCOME;

EID: 0033403439     PISSN: 02728087     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-1007131     Document Type: Article

References (133)

1. North Italian Endoscopic Club for the Study and Treatment of Esophageal Varices. Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. A prospective multicenter study. N Engl J Med 1988;319:983-989
2. Pagliaro L, D'Amico G, Soerensen TIA, et al. Prevention of first bleeding in cirrhosis. A meta-analysis of randomized trials of nonsurgical treatment. Ann Intern Med 1992;117:59-70
3. Pagliaro L, D'Amico G, Pasta L, et al. Portal hypertension in cirrhosis: Natural history. In: Bosch J, Groszmann RJ, eds. Portal Hypertension: Pathophysiology and Treatment. Oxford: Blackwell Scientific Publications, 1994; pp 72-92
4. Graham DY, Smith JL. The course of patients after variceal hemorrhage. Gastroenterology 1981;80:800-806
5. Hosking SW, Johnson AG. Gastric varices: A proposed classification and a guide to management Br J Surg 1988;75:195-196
6. Watanabe K, Kimura K, Matsutani S, Ohto M, Okuda K. Portal hemodynamics in patients with gastric varices. A study in 230 patients with esophageal or gastric varices using portal vein catheterization. Gastroenterology 1988;95:434-440
7. Sarin SK, Lahoti D, Saxena SP, Murthy NS, Makwana UK. Prevalence, classification and natural history of gastric varices: Long term follow-up study in 568 patients with portal hypertension. Hepatology 1992;16:1343-1349
8. Mathur SK, Dalvi AN, Someshwar V, Supe AN, Raniakhantan R. Endoscopic and radiological appraisal of gastric varices. Br J Surg 1990;77:432-435
9. Zanasi G, Rossi A, Grosso C, et al. The effect of endoscopic sclerotherapy of esophageal varices on the development of gastric varices. Endoscopy 1996;28:234-238
10. Westaby D, Hayes P, Gimson AE, Polson RJ, Williams R. Controlled trial of injection sclerotherapy for active variceal bleeding. Hepatology 1989;9:274-277
11. MacDougall BRD, Westaby D, Theodossi A, Dawson JL, Williams R. Increased long-term survival in variceal hemorrhage using injection sclerotherapy. Results of a controlled trial. Lancet. 1982;1:124-127
12. Infante-Rivard C, Esnaola S, Villeneuve JR. Role of endoscopic sclerotherapy in long-term management of variceal bleeding: A meta-analysis. Gastroenterology 1989;96:1087-1092
13. Stiegmann GV, Goff JS, Sun JH, Davis D, Silas D. Technique and early clinical results of endoscopic variceal ligation (EVL) Surg Endosc 1989;3:73-78
14. Soehendra N, Nam VC, Grimm H, Kempeneers I. Endoscopic obliteration of large esophago∼gastric varices with Bucrylate. Endoscopy 1986;18:25-26
15. Ramond M-J, Valla D, Mosnier J-F, et al. Successful endoscopic obturation of gastric varices with butyl cyanoacrylate. Hepatology 1989;10:488-493
16. Lee MS, Bong HK, Kim JO, et al. Endoscopic ligation of gastric varices using detachable snares and rubber bands [Abstract]. Gastroenterology 1996;110:A25
17. Koutsomanis D, Sebti MF, Essaid A. A randomized study of endoscopic haemostatic clipping versus endoscopic variceal ligation [Abstract]. Gastroenterology 1995;108:A630
18. Kitano S, Terblanche J, Kahn D, Bornman PC. Venous anatomy of the lower oesophagus in portal hypertension: Practical implications. Br J Surg 1986;73:525-531
19. Spence RA. The venous anatomy of the lower esophagus in normal subjects and patients with varices: An image analysis study. Br J Surg 1984;71:739-744
20. Noda T. Angioarchitectural study of esophageal varices with special reference to variceal rupture. Virchows Arch 1984;404: 381-392
21. Leung V, Sung JJY, Ahuja AT, et al. Large paraesophageal varices on endosonography predict recurrenceof esophageal varices and rebleeding. Gastroenterology 1997;112:1811-1816
22. Nagamine N, Ueno N, Tomiyama T, et al. A pilot study on modified endoscopic variceal ligation using ultrasonography with color Doppler function. Am J Gastroenterol 1998;93:150-155
23. Sakai T, Iwo T, Oho K, Toyonaga A, Tanikawa K. Influence of extravariceal collateral channel pattern on recurrence of esophageal varices after sclerotherapy. J Gastroenterol 1997;32:715-719
24. Sarin S, Kumar A. Gastric varices: Profile, classification. and management. Am J Gastroenterol 1989;84:1244-1249
25. Kim T, Shijo H, Kokawa H, et al. Risk factors for hemorrhage from gastric fundal varices. Hepatology 1997;25:307-312
26. Crafoord C, Freckner P. New surgical treatment of varicose veins of the esophagus. Acta Otolaryngol (Stockh) 1939;27:422-429
27. Kitano S, Iso Y, Yamaga H, Hashizume M, Wada H, Sugimaki K. Temporary deterioration of pulmonary functions after injection sclerotherapy for cirrhotic patients with esophageal varices. Eur Surg Res 1988;20:298-303
28. Laine L, Cook D. Endoscopic ligation compared with sclerotherapy for treatment of esophageal variceal bleeding. A meta-analysis Ann Intern Med 1995;123:280-287
29. Westaby D. Prevention of recurrent variceal bleeding. Gastrointest Endosc Clin North Am 1992;121-135
30. Westaby D, Binmöller K, de Franchis R, et al. Baveno II consensus statements: The endoscopic management of variceal bleeding. In: de Franchis R, ed. Portal Hypertension II. Proceedings of the Second International Consensus Workshop on Definitions, Methodology and Therapeutic Strategies. Oxford: Blackwell, 1996, p 126
31. Schuman BM, Beckman JW, Tedesco FJ, Griffin JW, Assad R. Complications of injection sclerotherapy: A review. Am J Gastroenterol 1987;82:823-829
32. Zambelli A, Arcidiacono PG, Arcidiacono R, et al. Complications of endoscopic variceal sclerotherapy: A multicenter study of 1192 patients [Abstract]. Gastroenterology 1993;104:A1023
33. Burroughs AK, McCormick PA. Prevention of rebleeding. Gastroenterol Clin North Am 1992;21:119-147
34. Singal A, Sarin SK, Sood GK, Broor SL. Ulcers after intravariceal sclerotherapy - correlation of symptoms and factors affecting healing. J Clin Gastroenterol 1990;12:250-254
35. Stiegmann GV, Yamamoto M. Endoscopic techniques for the management of active variceal bleeding. Gastrointest Endosc Clin North Am 1992;2:59-75
36. Ramond MJ, Valla D, Gotlib JP, Rueff B, Benhamou JP. Obturation endoscopique des varices oeso-gastriques par le Bucrylate. Gastroenterol Clin Biol 1986;10:575-579
37. Naga M, Foda A. An unusual complication of histoacryl injection. Endoscopy 1997;29:140
38. See A, Florent C, Lamy P, Levy VG, Bouvry M. Accidents vasculaires cerebraux par obturation endoscopique des varices oesophagiennes par l'Isobutyl-2-cyanoacrylate chez deux malades. Gastroenterol Clin Biol 1986;10:604-607
39. Kulling D, Hawes RH, Woo S, et al. Endoscopic injection of bleeding esophageal varices using poly-N-acetyl glucosamine gel induces hemostasis and varix obliteration in one session [Abstract]. Gastrointest Endosc 1998;47:AB71
40. Stiegmann GV, Sun JH, Hammond WS. Results of experimental endoscopic esophageal varix ligation. Am Surg 1988;54:105-108
41. Stiegmann GV, Cambre T, Sun JH. A new endoscopic elastic band ligating device. Gastrointest Endosc 1986;32:230-233
42. Hochberger J, Reh H, Horning F, Martens P, Hahn EG. Speedband multiligature of esophagogastric varices. Results of 159 acute and elective treatment in 60 patients. Biomed Technik 1997;42(suppl):496-497
43. Saeed ZA. The Saeed six-shooter: A prospective study of a new endoscopic multiple rubber-band ligator for the treatment of varices. Endoscopy 1996;28:559-564
44. Stiegmann GV, Goff JS, Michaletz-Onody PA, et al. Endoscopic sclerotherapy as compared with endoscopic ligation for bleeding esophageal varices. N Engl J Med 1992;326:1527-1532
45. Battaglia G, Capria A, Cestari R, et al. One-year outcome following endoscopic band ligation of varices: Results in 167 consecutive patients seen at 9 NIEC Centers. J Hepatol 1996;25(suppl 1):93
46. Sung JJY, Chung SCS. The use of a detachable mini-loop for the treatment of esophageal varices. Gastrointest Endosc 1998;47: 178-181
47. Cipolletta L, Bianco MA, Rotondano G, Pscopo R, Prisco A, Garofano ML. Emergency endoscopic ligation of actively bleeding gastric varices with a detachable snare. Gastrointest Endosc 1998;47:400-403
48. de Franchis R. Developing consensus in portal hypertension. J Hepatol 1996;25:390-394
49. Grace ND, Groszmann RJ, Garcia-Tsao G., et al. Portal hypertension and variceal bleeding: An AASLD single topic symposium. Hepatology 1998;28:868-880
50. Sarin SK, Guptan RC, Jain A, Sundaram KR. A randomized controlled trial of endoscopic variceal band ligation for primary prophylaxis of variceal bleeding. Eur J Gastroenterol Hepatol 1996;8:337-342
51. Lay CS, Tsai YT, Teg CY, et al. Endoscopic variceal ligation in prophylaxis of first variceal bleeding in cirrhotic patients with high-risk esophageal varices. Hepatology 1997;25:1346-1350
52. Barsoum MS. Boulous FI, El-Rooby A, Risk-Allah MA, Ibrahim AS. Tamponade and injection sclerotherapy in the management of bleeding esophageal varices. Br J Surg 1982;69:76-78
53. The Copenhagen Esophageal Varices Sclerotherapy Project. (EVASP) Sclerotherapy after first variceal hemorrhage in cirrhosis. A randomized multicenter trial. N Engl J Med 1984;311: 1594-1600
54. Paquet K-J. Feussner H. Endoscopic sclerosis and esophageal balloon tamponade in acute hemorrhage from esophago-gastric varices: A prospective controlled randomized trial. Hepatology 1985;5:580-583
55. Moretè M, Zaballa M, Bernal A, Ibanez S, Ojembarrena E, Rodriguez A. A randomized trial of tamponade or sclerotherapy as immediate treatment for bleeding esophageal varices. Surg Gynaecol Obstet 1988;167:331-334
56. Soederlund C, Ihre T. Endoscopic sclerotherapy vs conservative management of bleeding esophageal varices. Acta Chir Scand 1985;151:449-456
57. Larson AW, Cohen H, Zweiban B, et al. Acute esophageal variceal sclerotherapy. Results of a prospective randomized controlled trial. JAMA 1986;255:497-500
58. El Zayadi A, El Din S, Kabil M. Endoscopic sclerotherapy versus medical treatment for bleeding esophageal varices in patients with schistosomal liver disease. Gastrointest Endosc 1988;34:314-317
59. Alexandrino P, Alves MM, Fidalgo P, Matos L, Esteves AV, Veloso J, Oliveira AG, Moura MC. Is sclerotherapy the first choice treatment for active esophageal variceal bleeding in cirrhotic patients [Abstract]? J Hepatol 1990;11(suppl 2):S1
60. Cooperative Spanish-French Group for the Treatment of Bleeding Esophageal Varices. Randomized controlled trial comparing terlipressin vs. endoscopic injection sclerotherapy in the treatment of acute variceal bleeding and prevention of early rebleeding [Abstract]. Hepatology 1997;26:249A
61. Di Febo G, Siringo M, Vacirca M, et al. Somatostatin (SMS) and urgent sclerotherapy (US) in active esophageal variceal bleeding [Abstract]. Gastroenterology 1990;98:A583
62. Planas R, Quer JC, Boix J, et al. A prospective randomized trial comparing somatostatin and sclerotherapy in the treatment of acute variceal bleeding. Hepatology 1994;20:370-375
63. Shields R, Jenkins SA, Baxter JN, et al. Prospective randomized controlled trial comparing somatostatin and injection sclerotherapy in the control of acute variceal hemorrhage. J Hepatol 1992;16:128-137
64. Sung JJY, Chung SCS, Lai CW, et al. Octreotide infusion or emergency sclerotherapy for variceal hemorrhage. Lancet 1993; 342:637-641
65. Kravetz D, Group for the Study of Portal Hypertension. Octreotide vs sclerotherapy in the treatment of acute variceal bleeding [Abstract]. Hepatology 1996;24:206A
66. Jenkins SA, Shields R, Davies M, et al. A multicenter randomized trial comparing octreotide and injection sclerotherapy in the management and outcome of variceal hemorrhage. Gut 1997;41: 526-533
67. Laine L, El-Newihi HM, Migikowsky B, Sloane R, Garcia F. Endoscopic ligation compared with sclerotherapy for the treatment of bleeding esophageal varices. Ann Intern Med 1993;119:1-7
68. Gimson AES, Ramage JK, Panos MZ, et al. Randomized trial of variceal banding ligation versus injection sclerotherapy for bleeding esophageal varices. Lancet 1993;342:391-394
69. Jensen DM, Kovacs TOG, Randall GM, et al. Initial results of a randomized prospective study of emergency banding vs sclerotherapy for bleeding gastric or esophageal varices [Abstract]. Gastrointest Endosc 1993;39:279
70. Lo GH, Lai KH, Cheng JS, et al. A prospective, randomized trial of injection sclerotherapy versus banding ligation in the management of bleeding esophageal varices. Hepatology 1995;22:466-471
71. Hou MC, Lin HC, Kuo BIT, Chen CH, Lee FY, Lee SD. Comparison of endoscopic variceal injection sclerotherapy and ligation for the treatment of esophageal variceal hemorrhage: A prospective randomized trial. Hepatology 1995;21:1517-1522
72. Fakhry S, Orner M, Nouh A, et al. Endoscopic sclerotherapy versus endoscopic variceal ligation in the management of bleeding esophageal varices: A preliminary report of a prospective randomized study in schistosomal hepatic fibrosis [Abstract]. Hepatology 1995;22:251A
73. Sarin SK, Goyal A, Jain A, Guptan RC, Murthy MS. Randomized prospective trial of endoscopic sclerotherapy vs variceal ligation for bleeding esophageal varices: Influence on gastropathy, gastric varices and recurrences. J Hepatol 1997;26:826-832
74. Lo GH, Lai KH, Cheng JS, et al. Emergency banding ligation vs. sclerotherapy for the control of active bleeding from esophageal varices. Hepatology 1997;25:1101-1104
75. Young M, Sanowski R, Rasche R. Comparison and characterization of ulcerations induced by endoscopic ligation of esophageal varices versus endoscopic sclerotherapy. Gastrointest Endosc 1993;39:119-122
76. Mundo F, Mitrani C, Rodriguez G, Farca A. Endoscopic variceal treatment: Is band ligation taking over sclerotherapy [Abstract]? Am J Gastroenterol 1993;88:1493
77. Avgerinos A, Armonis A, Manolakopoulos S, et al. Endoscopic sclerotherapy versus variceal ligation in the long-term management of patients with cirrhosis after variceal bleeding. A prospective randomized trial. J Hepatol 1997;26:1034-1041
78. Baroncini D., Milandri GL, Borioni D, et al. A prospective, randomized trial of sclerotherapy versus ligation in the elective treatment of bleeding esophageal varices. Endoscopy 1997; 29:235-240
79. Masci E, Norberte L, D'Imperio N, et al. Prospective multicentric randomized trial comparing banding ligation with sclerotherapy of esophageal varices [Abstract]. Ital J Gastroenterol 1996;28(suppl 2):170
80. Veltzke W, Adler RE, Hintze RE. Role of endoscopic ligation in active variceal bleeding under emergency conditions [Abstract]. Endoscopy 1996;28:S50
81. Besson I, Ingrand P, Person B, et al. Sclerotherapy with or without octreotide for active variceal bleeding. N Engl J Med 1995;333:555-560
82. Sung JJY, Chung S, Yung MY, et al. Prospective randomized study of effect of octreotide on rebleeding from esophageal varices after endoscopic ligation. Lancet 1995;346:1666-1669
83. Avgerinos A, Nevens F, Raptis S, Fevery J, the ABOVE Study Group. Early administration of natural somatostatin increases the efficacy of sclerotherapy in acute bleeding esophageal variceal episodes. The European ABOVE study. Lancet 1997;350;1495-1499
84. Brunati S, Ceriani R, Curioni R Brunelli L, Repaci G, Morini L. Sclerotherapy alone vs. sclerotherapy plus terlipressin vs. sclerotherapy plus octreotide in the treatment of acute variceal hemorrhage [Abstract]. Hepatology 1996;24:207A
85. Signorelli S, Negrini F, Paris B, Bonelli M, Girola M. Sclerotherapy with or without somatostatin or octreotide in the treatment of acute variceal hemorrhage: Our experience [Abstract]. Gastroenterology 1996;110:A1326
86. Ortiz J, Villanueva C, Sabat M, et al. Somatostatin alone or combined with emergency sclerotherapy for acute variceal bleeding [Abstract], Gastrointest Endosc 1997;45:AB77
87. Novella MT, Villanueva C, Ortiz J, et al. Octreotide vs. sclerotherapy and octreotide fo acute variceal bleeding. A pilot study [Abstract]. Hepatology 1996;24:207A
88. Sung JJY, Yeo W, Suen R, et al. Injection sclerotherapy for variceal bleeding in patients with hepatocellular carcinoma: Cyanoacrylate versus sodium tetradecyl sulfate. Gastrointest Endosc 1998;47:235-239
89. Sung JJY, Lee YT, Suen R, Chung SCS. Banding is superior to cyanoacrylate for the treatment of esophageal variceal bleeding: A prospective randomized study [Abstract]. Gastrointest Endosc 1998;47:AB77
90. Thakeb F, Salama Z, Salama H, Abdel Rauf T, Abdel Kader S, Abdel Hamid S. The value of combined use of N-butyl-2-cyanoacrylate and ethanolamine oleate in the management of esophagogastric varices. Endoscopy 1995;27:358-364
91. Feretis C, Dimopoulos C, Benakis P, Kalliakmanis B, Apostolidis N. N-butyl-2-cyanoacrylate (Histoacryl) plus sclerotherapy vs. sclerotherapy alone in the treatment of bleeding esophageal varices: A randomized prospective study. Endoscopy 1995;27: 355-357
92. Terblanche J, Bornman PC, Kahn D, et al. Failure of repeated injection sclerotherapy to improve long-term survival after esophageal variceal bleeding. Lancet 1983;2:1328-1332
93. Westaby D, MacDougall BRD, Williams R. Improved survival following injection sclerotherapy for esophageal varices: Final analysis of a controlled trial. Hepatology 1985;5:627-631
94. Korula J, Balart L, Radvan G, et al. A prospective randomized controlled trial of chronic esophageal variceal sclerotherapy. Hepatology 1985;5:584-589
95. Burroughs AK, McCormick PA, Siringo S, Phillips A, Sprengers D, McIntyre N. Prospective randomized trial of long term sclerotherapy for variceal rebleeding using the same protocol to treat rebleeding in all patients. Final report [Abstract], J Hepatol 1989;9:(suppl 1):S12
96. Gregory PB. VA co-operative variceal sclerotherapy group. Sclerotherapy for male alcoholic cirrhotic patients who have bled from esophageal varices: Results of a randomized, multicenter clinical trial. Hepatology 1990;11:618-625
97. Rossi V, Calés P, Bourtin P, et al. B, Pujol P, Valentin S, D'Aubugny N, Joubaud F, Boyer J. Prevention of recurrent bleeding in alcoholic cirrhotic patients: A prospective controlled trial of propranolol and sclerotherapy. J Hepatol 1991;12: 283-289
98. Fleig WE, Stange EF, Hunecke R, et al. Prevention of recurrent bleeding in cirrhotics with recent variceal hemorrhage: Prospective, randomized comparison of propranolol and sclerotherapy. Hepatology 1987;7:355-361
99. Terés J, Bosch J, Bordas JMA, et al. Propranolol vs sclerotherapy in the prevention of variceal rebleeding. A randomized controlled trial. Gastroenterology 1993;105:1508-1514
100. Alexandrino PT, Alves MM, Pinto Correia J. Propranolol or endoscopic sclerotherapy in the prevention of recurrence of variceal bleeding. A prospective, randomized controlled trial. J Hepatol 1988;7:175-185
101. Dollet JM, Champigneulle B, Patris A, Bigard A, Gaucher P. Sclérothérapie endoscopique contre propranolol après hémorrhagie par rupture de varices oesophagiennes chez le cirrhotique. Résultats à 4 ans d'une étude randomisée. Gastroenterol Clin Biol 1988;12:234-239
102. Westaby D, Polson RJ, Gimson AES, Hayes PC, Hayllar K. Williams R. A controlled trial of oral propranolol compared with injection sclerotherapy for the long-term management of variceal bleeding. Hepatology 1990;11:353-359
103. Liu JD, Jeng YS, Chen P, Siauw CP, Ko FT, Lin KY. Endoscopic injection sclerotherapy and propranolol in the prevention of recurrent variceal bleeding [Abstract]. World Congress of Gastroenterology Abstract Book. Abingdon, UK: The Medicine Group (UK) Ltd. 1990, FP1181
104. Martin T, Taupignon A, Lavignolle A, Perrin D. Prévention des récidives hémorrhagiques chez les malades atteints de cirrhose. Résultats d'une étude controlée comparant propranolol et sclérose endoscopique. Gastroenterol Clin Biol 1991;15:833-837
105. Dasarathy S, Dwivedi M, Bhargava DK, Sundaram KR, Ramachandran K. A prospective randomized trial comparing repeated endoscopic sclerotherapy and propranolol in decompensated (Child class B and C) cirrhotic patients. Hepatology 1992;16:89-94
106. Westaby D, Melia W, Hegarty J, Gimson AE, Stellon AJ, Williams R. Use of propranolol to reduce the rebleeding rate during injection sclerotherapy prior to variceal obliteration. Hepatology 1986;4:673-675
107. Jensen LS, Krarup N. Propranolol in prevention of rebleeding from esophageal varices during the course of endoscopic sclerotherapy. Scand J Gastroenterol 1989;24:339-345
108. Gerunda GE, Neri D, Zangrandi F, et al. Nadolol does not reduce early rebleeding in cirrhotics undergoing endoscopic variceal sclerotherapy (EVS): A multicenter randomized controlled trial [Abstract]. Hepatology 1990;12:988
109. Lundell L, Leth R, Lind T, Lonroth H, Sjovall M, Olbe L. Evaluation of propranolol for prevention of recurrent bleeding from esophageal varices between sclerotherapy sessions. Acta Chir Scand 1990;156:711-715
110. Bertoni G, Fornaciari G, Beltrami M, et al. Nadolol for prevention of variceal rebleeding during the course of endoscopic injection sclerotherapy: A randomized pilot study [Letter]. J Clin Gastroenterol 1990;12:364-365
111. Vinel JP, Lamouliatte H, Calés P, et al. Propranolol reduces the rebleeding rate during injection sclerotherapy before variceal obliteration. Gastroenterology 1992;102:1760-1763
112. Acharya SK, Dasarathy S, Saksena S, Pande JN. A prospective randomized study to evaluate propranolol in patients undergoing long-term endoscopic sclerotherapy. J Hepatol 1993;19:291-300
113. Avgerinos A, Rekoumis G, Klonis C, et al. Propranolol in the prevention of recurrent upper gastrointestinal bleeding in patients with cirrhosis undergoing endoscopic sclerotherapy. A randomized controlled trial. J Hepatol 1993;19:301-311
114. Vickers C, Rhodes J, Chesner I, et al. Prevention of rebleeding from esophageal varices: Two-year follow up of a prospective controlled trial of propranolol in addition to sclerotherapy. J Hepatol 1994;21:81-87
115. Villanueva C, Torras X, Tomas A. Nadolol como coadyuvante a la scleroterapia en el tratamiento electivo de la hemorragia por varices esofagicas. Estudio randomizado y controlado [Abstract]. Gastroenterol Hepatol 1992;15:341
116. Primignani M, Andreoni B, Carpinelli L, et al. Sclerotherapy plus octreotide vs. sclerotherapy alone in the prevention of early rebleeding from esophageal varices: A randomized, double blind, placebo-controlled, multicenter trial. Hepatology 1995; 21:1322-1327
117. Jenkins SA, Baxter JN, Critchley M, et al. Randomised trial of octreotide for long term management of cirrhosis after variceal hemorrhage. Br Med J 1997;315:1338-1441
118. D'Amico G, Politi F, Morabito A, et al. Octreotide compared with placebo in a treatment strategy for early rebleeding in cirrhosis. A double blind randomized pragmatic trial. Hepatology 1998;8:1206-1214
119. D'Amico G, Pagliaro L, Bosch J. The treatment of portal hypertension: A meta-analytic review. Hepatology 1995;2:332-354
120. Villanueva C, Balanzò J, Novella MT, et al. Nadolol plus isosorbide mononitrate compared with sclerotherapy for the prevention of variceal rebleeding. N Engl J Med 1996;334: 1624-1629
121. Gallego A, Villanueva C, Ortiz J, et al. Endoscopic ligation compared with nadolol plus isosorbide-5-mononitrate for the prevention of variceal rebleeding. Preliminary results of a prospective and randomized trial [Abstract]. Gastrointest Endosc 1997;45:AB68
122. Masumoto H, Toyonaga A, Oho K. Ligation plus low-volume sclerotherapy for high-risk esophageal varices: Comparisons versus ligation therapy or sclerotherapy alone. J Gastroenterol 1998;33:1-5
123. Saeed ZA, Stiegmann GV, Ramirez FC, et al. Endoscopic variceal ligation is superior to combined ligation and sclerotherapy for esophageal varices: A multicenter prospective randomized trial. Hepatology 1997;25:71-74
124. Lo GH, Lai KH, Cheng JS, et al. The additive effect of sclerotherapy to patients receiving repeated endoscopic variceal ligation: A prospective randomized trial. Hepatology 1998;28:391-395
125. Hokari K, Kato M, Katagiri M, et al. A new combined therapeutic method for esophageal varices: Endoscopic variceal ligation followed by mucosa-fibrosing with microwave [Abstract]. Gastroenterology 1998;114:L0242
126. Primignani M, Materia M, Preatoni P, et al. Does endoscopic treatment of esophageal varices with sclerotherapy or band ligation influence the evolution of portal hypertensive gastropathy in cirrhotic patients [Abstract]? Gastroenterology 1998;114:L 0517
127. Trudeau W, Prindiville T. Endoscopic injection sclerosis in bleeding gastric varices. Gastrointest Endosc 1985;32:264-268
128. Sarin SK, Sachdev G, Nanda R, Misra SP, Broor SL. Endoscopic sclerotherapy in the treatment of gastric varices. Br J Surg 1988;75:747-750
129. Gimson AES, Westaby D, Williams R. Endoscopic sclerotherapy in the management of gastric variceal hemorrhage. J Hepatol 1991;13:274-278
130. Chang KY, Wu CS, Chen PC. Prospective, randomized trial of hypertonic glucose water and sodium tetradecilsulfate for gastric variceal bleeding in patients with advanced liver cirrhosis. Endoscopy 1996;28:481-486
131. Sarin SK. Long-term follow-up of gastric variceal sclerotherapy: An eleven-year experience. Gastrointest Endosc 1997;46:8-14
132. Williams SGJ, Peters RA, Westaby D. Thrombin - an effective treatment for fundal gastric varices ? Gut 1994;35:1287-1289
133. Oho K, Iwao T, Sumino M, Toyonaga A, Tanikawa K. Ethanolamine oleate versus butyl-cyanoacrylate for bleeding gastric varices: A non-randomized study. Endoscopy 1995;27: 349-354