A multicentre randomised trial comparing octreotide and injection sclerotherapy in the management and outcome of acute variceal haemorrhage

Gut

Volumn 41, Issue 4, 1997, Pages 526-533

  Jenkins, S A ^a   Shields, R ^a   Davies, M ^b   Elias, E ^b   Turnbull, A J ^c   Bassendine, M F ^c   James, O F W ^c   Iredale, J P ^d   Vyas, S K ^d   Arthur, M J P ^d   Kingsnorth, A N ^a   Sutton, R ^a,e  

^a ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^b QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^c FREEMAN HOSPITAL   (United Kingdom)

^d SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^e UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Injection sclerotherapy; Octreotide; Variceal haemorrhage

Indexed keywords

MONOETHANOLAMINE OLEATE; OCTREOTIDE;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; ENDOSCOPIC THERAPY; ESOPHAGUS VARICES BLEEDING; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCLEROTHERAPY;

EID: 9844249095     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.41.4.526     Document Type: Article

References (53)

1. McCormick PA, Kaye GL, Greenslade L, Cardin F, Hobbs KEF, Burroughs AK, Esophageal staple transection as a salvage procedure after failure of acute sclerotherapy. Hepatology 1992; 15: 403-6.
2. Sarin SK, Sachdev G, Nanda R, Batra SK, Anand BS. Comparison of two time schedules for endoscopic sclerotherapy: a prospective randomised controlled trial. Gut 1986; 18: 710-3.
3. Fessel JM, Conn HO. An analysis of the causes and prevention of hepatic coma [abstract]. Gastroenterology 1972; 62: A191.
4. Conn HO. The hepatic encephalopathies. In: Conn HO, Bircher J, eds. Hepatic encephalopathy: management with lactulose and related carbohydrates. East Lansing, MI: Medi-Ed Press, 1984: 3-14.
5. Gines A, Escorsell A, Gines P, Salo J, Jimenez W, Ingladal L, et al. Incidence, predictive factors and prognosis of hepatorenal syndrome in cirrhosis with ascites. Gastroenterology 1993; 105: 229-36.
6. Terblanche J, Burroughs AK, Hobbs KEF. Controversies in the management of bleeding oesophageal varices. N Engl J Med 1984; 320: 1393-8.
7. Zambelli A, Acridiacono PG, Acridiacono R. Complications of endoscopic variceal sclerotherapy (ESV): a multicentre study of 1192 patients [abstract]. Gastroenterology 1993; 104: A1023.
8. Kravetz D, Bosch J, Teres J, Bruix J, Rimola A, Rodes J. Comparison of intravenous somatostatin and vasopressin infusions in treatment of acute variceal haemorrhage. Hepatology 1984; 4: 442-6.
9. Jenkins SA, Baxter JN, Corbett W, Devitt P, Ware J, Shields R. A prospective randomised controlled trial comparing somatostatin and vasopressin in controlling acute variceal haemorrhage. BMJ 1985; 290: 275-8.
10. Testoni PA, Masci E, Passaretti D, Malesci A, Tittobello A, Comin U, et al. Comparison of somatostatin and cimetidine in the treatment of acute bleeding oesophageal varices. Curr Ther Res 1986; 39: 758-66.
11. Bagarini M, Albertini V, Anza M, Barlattani A, Bracci F, et al. Effect of somatostatin in controlling bleeding from oesophageal varices. Ital J Surg Sci 1987; 17: 21-6.
12. Loperfido S, Godena F, Tosolini G, Dematte P, Burei F, Gasparini G, et al. La somatostatina nel traitmento dell emeragia da varici esophago-gastrische. Rec Prog Med 1987; 78: 82-6.
13. Cardona C, Vida F, Balanzo J, Cusso X, Farre A, Guarer C. Efficia terapentica de la somatostatina versus vasopressina mas nitroglycerina en la haemorrhagia actura por varices esophagastricas. Gastroenterol y Hepatol 1989; 12: 19-22.
14. Valenzuela JE, Schubert T, Fogel MR, Strong RM, Levine J, Mills PR, et al. A multicentre randomised double-blind trial of somatostatin in the management of acute haemorrhage from esophageal varices. Hepatology 1980; 10: 958-61.
15. Burroughs AK, McCormick PA, Hughes MD, Springer D, D'Haygere F, McIntyre N, et al. Randomised double-blind placebo-controlled trial of somatostatin for variceal bleeding. Emergency control and prevention of early variceal bleeding. Gastroenterology 1990; 99: 1388-95.
16. Saari A, Klvilaakso E, Inberg M, Paakkonen M, Lahtinen J. Comparison of somatostatin and vasopressin in bleeding oesophageal varices. Am J Gastroenterol 1990; 83: 804-7.
17. Agverinos A, Klonis C, Rekoumis G, Gouma P, Papadimitriou N, Raptis S. A prospective randomised trial comparing somatostatin, balloon tamponade and the combination of both methods in the management of acute variceal haemorrhage. J Hepatol 1991; 13: 78-83.
18. Jaramillo JL, de la Manta M, Mino G, Costan G, Gomez-Comacho F. Somatostatin versus Sengstaken balloon tamponade for primary haemostasis of bleeding oesophageal varices. J Hepatol 1991; 12: 100-5.
19. Shields R, Jenkins SA, Baxter JN, Kingsnorth A, Ellenbogen S, Martin C, et al. A prospective randomised controlled trial comparing the efficacy of somatostatin with injection sclerotherapy in the control of bleeding oesophageal varices. J Hepatol 1992; 16: 128-37.
20. Walker S, Kreichgauer HP, Bode JC. Terlipressin vs somatostatin in bleeding oesophageal varices. A controlled, double-blind study. Hepatology 1992; 15: 1028-30.
21. Hsai HC, Lee FY, Tsai YE. Comparison of somatostatin and vasopressin in the control of acute oesophageal variceal haemorrhage - a randomised controlled study. Chinese J Gastroenterol 1990; 7: 71-8.
22. Hanisch E, Doertenbach J, Usadel KH. Somatostatin in acute bleeding varices. Pharmacology and rationale for use. Drugs 1992; 44 (suppl): 24-35.
23. Jenkins SA, Baxter JN, Corbett WA, Shields R. Effects of a somatostatin analogue SMS 201-995 on hepatic haemodynamics in the pig and on intravariceal pressure in man. Br J Surg 1985; 72: 1009-12.
24. Navasa M, Bosch J, Chesta J, Bru C, Pizcueta P, Garcia-Pagan JC, et al. Haemodynamic effects of subcutaneous administration of SMS 201-995, a long acting analogue of somatostatin in patients with cirrhosis and portal hypertension [abstract]. J Hepatol 1988; 7 (suppl 1): S64.
25. McCormick PA, Dick R, Siringo S, Wagstaff D, Chesta J, McIntyre N, Burroughs AK. Octreotide reduces azygos blood flow in cirrhotic patients with portal hypertension. Eur J Gastroenterol Hepatol 1990; 2: 489-92.
26. McKee R. A study of octreotide in oesophageal varices. Digestion 1990; 45 (suppl): 60-5.
27. Silvain C, Carpentier S, Sautereau S, Fratte JM, Ingrand E, Fort E, et al. A randomised trial of glypressin plus transdermal nitroglycerin versus octreotide in the control of acute variceal haemorrhage. Hepatology 1991; 14: 1339.
28. Hwang S-J, Lin H-H, Chang C-F, Lee F-Y, Lu C-W, Hsia H-C, et al. A randomised controlled trial comparing octreotide and vasopressin in the control of acute esophageal variceal bleeding. J Hepatol 1992; 16: 320-5.
29. Sung JJY, Chung S, Lai C-W, Chan FKL, Leung JWC, Yung ML, et al. Octreotide infusion or emergency sclerotherapy for variceal haemorrhage. Lancet 1993; 342: 637-41.
30. Elsdhoff JD. Surviving proportional hazards. Hepatology 1983; 73: 1631-5.
31. Child CG, Turcotte JG. Surgery and portal hypertension. In: Child CG, Dumphy JE, eds. Major problems in clinical surgery: the liver and portal hypertension, Vol. 1. Philadelphia: Saunders, 1964: 1-85
32. Terblanche J, Kahn D, Campbell AH, Jonker MA, Campbell JH, Wright J, et al. Failure of repeated injection sclerotherapy to improve long-term survival after oesophageal variceal bleeding. Lancet 1983; ii: 1328-32.
33. Stiegmann GV, Goff JS, Michaletz-Onody PA, Korolv J, Liebermann D, Saced ZA, et al. Endoscopic sclertherapy as compared with endoscopic ligation for bleeding oesophageal varices. N Engl J Med 1992; 326: 1527-32.
34. Laine L, El-Newihi HM, Migikovsky B, Sloane R, Garcia F. Endoscopic ligation compared with sclerotherapy for the treatment of bleeding oesophageal varices. Ann Intern Med 1993; 119: 1-7.
35. Gimson AES, Ramage JK, Panoz MZ, Hayllar K, Harrison PM, Williams R, et al. Randomised trial of variceal bleeding ligation versus injection sclerotherapy for bleeding oesophageal varices. Lancet 1993; 342: 391-4.
36. Lo G-H, Laik K-H, Chang C-F, Shew M-T, Jeng J-S, Huang R-L, et al. Endoscopic injection sclerotherapy vs. endoscopic variceal ligation in arresting variceal bleeding in patients with advanced hepatocellular carcinoma. J Hepatol 1994; 21: 1048-52.
37. Howes N, Larman A, Thomas M, Suares S, Jenkins SA, Gilmore IT, et al. High cumulative mortality from recurrent versus first variceal haemorrhage underlines need to prevent rebleedmg [abstract]. Gastroenterology 1995; 108 (suppl): A1087.
38. Lin CI, Wei J, Cheng KK, Ho LT. Electropharmacological effects of sandostatin in human atrial fibres. Int J Cardiol 1991; 31: 313.
39. McCormick PA, Chin J, Greenslade L, Karatapanis S, Dick R, McIntyre N, Burroughs AK. Cardiovascular effects of octreotide in patients with hepatic cirrhosis. Hepatology 1995; 21: 1255-60.
40. Minocha A, Dean HA Jr. Octreotide-induced acute hepatic toxicity. Am J Gastroenterol 1991; 81: 525-6.
41. Gines A, Salmeron J, Gines P, Jimenez W, Saio J, Piera C, et al. Effects of somatostatin on renal function in cirrhosis. Gastroenterology 1992; 103: 1868-74.
42. Mountokalakis T, Kallivretakis N, MayopoulouSymvoulidou D, Karvountzis G, Tulis G. Enhancement of renal function by a long acting somatostatin analogue in patient with decompensated cirrhosis. Nephrol Dial Transplant 1988; 13: 604-7.
43. Carcia-Escribano C, Diez-Marques ML, Gonzales-Rubio M, Rodriguez-Puyol M, Rodriguez-Puyol D. Somatostatin antagonist angiotensin II effects on mesoangial cell contraction and glomerular filtration. Kidney Int 1993; 43: 324-33.
44. Parbhoo S. The management of bleeding in liver disease. Br J Hosp Med 1975; 15: 17-28.
45. Blavianos P, Gimson AES, Westaby D, Williams R. Balloon tamponade in variceal bleeding; use and misuse. BMJ 1989; 298: 1158.
46. Westaby D. The management of active variceal bleeding. Intensive Care Med 1988; 14: 100-5.
47. Rector WG Jr. Drug therapy for portal hypertension. Ann Intern Med 1986; 106: 96-107.
48. Gimson AE, Westaby D, Hegarty J, Watson A, Williams R. A randomised trial of vasopressin and vasopressin plus nitro- glycerin in the control of the acute variceal haemorrhage. Hepatology 1986; 6: 410-6.
49. Tsai YT, Lay CT, Lai KH, Lai WW, Ng YS, Yeh JY, et al. Controlled trial of vasopressin plus nitroglycerin in the control of acute variceal haemorrhage. Hepatology 1986; 6: 410-3.
50. Bosch J, Grossman RJ, Garcia Pagnan JC, Teres J, Garcia Tsaao M, Navasa A, et al. Association of transdermal nitroglycerin to vasopressin infusion in the treatment of variceal haemorrhage: a placebo controlled clinical trial. Hepatology 1989; 10: 962-8.
51. Freeman JG, Boden I, Record CO. Controlled trial of terlipressin (glypressin) in the management of acute variceal bleeding. J Clin Gastroenterol 1989; 11: 58-60.
52. Walker S, Stiefel A, Raeosch R, Dommerell S. Terlipressin in bleeding oesophageal varices: a placebo controlled double-blind study. Hepatology 1986; 6: 112-5.
53. Soderlund C, Magnusson I, Torngren S, Lundell L. Terlipressin (triglycyl-lysine vasopressin) controls acute bleeding oesophageal varices: a double-blind, randomised, placebo-controlled trial. Scand J Gastroenterol 1990; 25: 622-30.