Synthesis and biological evaluation of a conformationally free seco-analogue of the immunosuppressant FR901483

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 12, 1999, Pages 2891-2897

  Bonjoch, J ^a   Diaba, F ^a   Puigbo G ^a   Sole D ^a   Segarra, V ^b   Santamaria L ^b   Beleta, J ^b   Ryder, H ^b   Palacios, J M ^b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b Res Center Cardener 68 74 08024 ^*  (Spain)

Author keywords

Immunological activity; Natural products; Phosphonic acid and derivatives; Poliycyclic heterocyclic compounds

Indexed keywords

FR 901483; IMMUNOSUPPRESSIVE AGENT; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; CONTROLLED STUDY; CYCLIZATION; DRUG ACTIVITY; DRUG CONFORMATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MONONUCLEAR CELL; PROTON NUCLEAR MAGNETIC RESONANCE;

CELL DIVISION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; ORGANOPHOSPHORUS COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033400773     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00250-3     Document Type: Article

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