Effects of ebselen, a glutathione peroxidase mimic, in several models of mitocbondrial dysfunction

Annals of the New York Academy of Sciences

Volumn 893, Issue , 1999, Pages 254-257

  Boireau, Alain ^a   Dubedat, Pierre ^a   Bordier, Françoise ^a   Coimbra, Madeleine ^a   Meunier, Mireille ^a   Imperato, Assunta ^a   Moussaoui, Saliha ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; BUTYLCRESOL; CALCIUM ION; CITRIC ACID; CYCLOSPORIN A; EBSELEN; FERROUS ION; NONSTEROID ANTIINFLAMMATORY AGENT; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL CELL; CONFERENCE PAPER; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; LIPID PEROXIDATION; LIVER MITOCHONDRION; LIVER PROTECTION; MITOCHONDRION SWELLING; NEUROPROTECTION; NONHUMAN; OPTICAL DENSITY; RAT;

ANIMALIA;

EID: 0033398171     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb07830.x     Document Type: Conference Paper

References (8)

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2. 2. Yamaguchi, T., K. Sano, K. Takakura, I. Saito, Y. Shinohara, T. Asano & H. Yasuhara. 1998. Ebselen in acute ischemic stroke. A placebo-controlled, double-blind clinical trial. Stroke 29: 12-17
3. 3. Saito, I., T. Asano, K. Sano, K. Takakura, H. Abe, T. Yoshimoto, H. Kikuchi, T. Ohta & S. Ishibashi. 1998. Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage. Neurosurgery 42: 269-278.
4. 4. Dawson, D.A., H. Masayasu, D.I. Graham & I.M. MacRae. 1995. The neuroprotective efficacy of ebselen (a glutathione peroxidase mimic) on brain damage induced by transient focal cerebral ischaemia in the rat. Neurosci. Lett. 185: 65-69.
5. 5. Takasago, T., E.E. Peters, D.I. Graham, H. Masayasu & I.M. MacRae. 1997. Neuroprotective efficacy of ebselen, an anti-oxidant with anti-inflammatory actions, in a rodent model of permanent middle cerebral artery occlusion. Br. J. Pharmacol. 122: 1251-1256.
6. 6. Bindoli, A. 1988. Lipid peroxidation in mitochondria. Free Radical Biol. Med. 5: 247-261.
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