Lyme disease: Pathogenesis and vaccine development

Zentralblatt fur Bakteriologie

Volumn 289, Issue 5-7, 1999, Pages 690-695

  Simon, Markus M ^a   Bauer, Yvonne ^b   Zhong, Weimin ^a   Hofmann, Heidelore ^c   Wallich, Reinhard ^b  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Borrelia burgdorferi; Protection; T cell response; Vaccine

Indexed keywords

EID: 0033395530     PISSN: 09348840     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0934-8840(99)80034-6     Document Type: Conference Paper

References (11)

1. De Silva, A. M. and E. Fikrig: Borrelia burgdorferi genes selectively expressed in ticks and mammals. Parasitol. Today 13 (1997) 267-270
2. Schaible, U. E., L. Gern, R. Wallich, M. D. Kramer, M. Prester, and M. M. Simon: Distinct patterns of protective antibodies are generated against Borrelia burgdorferi in mice experimentally inoculated with high and low doses of antigen. Immunol. Lett. 36 (1993) 219-226
3. Schaible, U. E., R. Wallich, M. D. Kramer, L. Gern, J. F. Anderson, C. Museteanu, and M. M. Simon: Immune sera to individual Borrelia burgdorferi isolates or recombinant OspA thereof protect SCID mice against infection with homologous strains but only partially or not at all against those of different OspA/OspB genotype. Vaccine 11 (1993) 1049-1054
4. Sigal, L. H.: Lyme disease: A review of aspects of its immunology and immunopatho genesis. Annu. Rev. Immunol. 15 (1997) 63-92
5. Simon, M. M., U. E. Schaible, M. D. Kramer, C. Eckerskorn, C. Museteanu, K. Müller-Hermelink, and R. Wallich: Recombinant outer surface protein A from Borrelia burgdorferi induces antibodies protective against spirochaetal infection in mice. J. Infect. Dis. 164 (1991) 123-132
6. Simon, M. M., L. Gern, P. Hauser, W. Zhong, P. J. Nielsen, M. D. Kramer, C. Brenner, and R. Wallich: Protective immunization with plasmid DNA containing the outer surface lipoprotein A gene of Borrelia burgdorferi is independent of an eukaryotic promoter. Eur. J. Immunol. 26 (1996) 2831-2840
7. Steere, A. C: Lyme disease. N. Engl. J. Med. 321 (1989) 586-596
8. Steere, A. C., V. K. Sikand, F. Meurice, D. L. Parenti, E. Fikrig, R. T. Schoen, J. Nowakowski, C. H. Schmid, S. Laukamp, C. Buscarino, and D. S. Krause: The Lyme Disease Vaccine Study Group. Vaccination against Lyme disease with recombinant Borrelia burgdorferi Outer-surface lipoprotein A with adjuvant. N. Engl. J. Med. 339 (1998) 209-215
9. Wallich, R., C. Brenner, M. D. Kramer, and Simon M. M.: Molecular cloning and immunological characterization of a novel linear-plasmid-encoded gene, pG, of Borrelia burgdorferi expressed only in vivo. Infect. Immun. 63 (1995) 3327-3335
10. Wilske, B., A. G. Barbour, S. Bergström, N. Burman, B. I. Restrepo, P. A. Rosa, T. Schwan, E. Soutschek, and R. Wallich: Antigenic variation and strain heterogeneity in Borrelia spp. Res. Microbiol. 143 (1992) 583-596
11. Zhong, W., T. Stehle, C. Museteanu, A. Siebers, L. Gern, M. Kramer, R. Wallich, and M. M. Simon: Therapeutic passive vaccination against chronic Lyme disease in mice. Proc. Natl. Acad. Sci. USA 94 (1997) 12533-12538