Development of a bioartificial pancreas: I. Long-term propagation and basal and induced secretion from entrapped βTC3 cell cultures

Biotechnology and Bioengineering

Volumn 66, Issue 4, 1999, Pages 219-230

  Papas, K K ^a,c   Long Jr , R C ^b   Sambanis, A ^a   Constantinidis, I ^b  

^a Georgia Institute of Technology   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

TC3 cells; Bioartificial pancreas; Bioenergetics; Cell encapsulation; Glucose effects; Insulin secretion; Nuclear magnetic resonance (NMR) spectroscopy

Indexed keywords

BIOMEDICAL ENGINEERING; CELL CULTURE; GLUCOSE; INSULIN; METABOLISM; NONINVASIVE MEDICAL PROCEDURES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXYGEN; TISSUE; TRANSPLANTATION (SURGICAL);

BIOARTIFICIAL PANCREAS; BIOENERGETICS;

IMPLANTS (SURGICAL);

INSULIN;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL HYPOXIA; CELL VIABILITY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN METABOLISM; INSULIN RELEASE; METABOLIC REGULATION; MOUSE; NONHUMAN; PANCREAS PERFUSION;

ANIMALS; BIOTECHNOLOGY; CELL LINE; DIABETES MELLITUS, TYPE 1; ENERGY METABOLISM; GLUCOSE; HUMANS; INSULIN; ISLETS OF LANGERHANS; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANES, ARTIFICIAL; MICE; PANCREAS, ARTIFICIAL; PERFUSION; TIME FACTORS;

ANIMALIA;

EID: 0033388442     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(1999)66:4<219::AID-BIT3>3.0.CO;2-B     Document Type: Article

References (61)

1. Alleyassine H. 1970. Energy requirements for insulin release from rat pancreas in vitro. Endocrinology 87:84-89.
2. Benson JP, Papas KK, Constantinidis I, Sambanis A. 1997. Towards the development of a bioartificial pancreas: effects of poly-L-lysine on alginate beads with βTC3 cells. Cell Transplant 6:395-402.
3. 31P NMR. J Magn Reson 72:168-172.
4. Chen C-F, Chern H-T, Leu F-J, Chang T-M, Shian L-R, Sun AM. 1994. Xenotransplantation of microencapsulated canine islets into diabetic rats. Artif Org 18:193-197.
5. Chicheportiche D, Reach G. 1988. In vitro kinetics of insulin release by microencapsulated rat islets: effect of the size of microcapsules. Diabetologia 31:54-57.
6. Clark SA, Quaade C, Constandy H, Pernille H, Halban P, Ferber S, Newgard CB, Normingtion K. 1997. Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression. Diabetes 46:958-967.
7. Colton CK, Dionne KE, Yarmush ML. 1988. Oxygen effects on pancreatic islet insulin secretion in hybrid artificial pancreas. In: Skalak R, Fox CF, editors. Tissue engineering. New York: Liss.
8. 13C NMR study of the effects of alginate/poly-L-lysine/alginate entrapment on glucose metabolism by βTC3 mouse insulinoma cells. Cell Molec Biol 43: 721-729.
9. 31P NMR spectroscopic studies of immunoprotected, insulin-secreting AtT-20 cells. Biotechnol Bioeng 47:431-443.
10. Constantinidis I, Sambanis A. 1998. Non-invasive monitoring of tissue-engineered constructs by nuclear magnetic resonance methodologies. Tissue Eng 4:9-17.
11. Coore HG, Randle PJ. 1964. Regualtion of insulin secretion studied with pieces of rabbit pancreas incubated in vitro. Biochem J 93:66-77.
12. Dionne KE, Colton CK, Yarmush ML. 1989. Effect of oxygen on isolated pancreatic tissue. Trans Am Soc Artif Intern Org 35:739-741.
13. Dionne KE, Colton CK, Yarmush ML. 1991. A microperifusion system with environmental control for studying insulin secretion by pancreatic tissue. Biotechnol Prog 7:359-368.
14. Efrat S, Fusco-DeMane D, Lemberg H, al Emran O. Wang X. 1995. Conditional transformation of a pancreatic beta-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene. Proc Natl Acad Sci USA 92:3576-3580.
15. Efrat S, Linde S, Kofod H, Spector D, Delannoy M, Grant S, Hanahan D, Baekkeskov S. 1988. Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene. Proc Natl Acad Sci USA 85.9037-9041.
16. Efrat S, Leiser M, Surana M, Tal M, Fusco-Damane D, Fleischer N. 1993. Murine insulinoma cell line with normal glucose regulated insulin secretion. Diabetes 42:901-907.
17. Erecinska M, Bryla J, Michalik M, Meglasson MD. Nelson D. 1992. Energy metabolism in islets of Langerhans. Biochim Biophys Acta 1101: 273-295.
18. Fan M-Y, Lum Z-P, Fu X-W, Levesque L, Tai IT, Sun AM. 1990. Reversal of diabetes in BB rats by transplantation of encapsulated pancreatic-islets. Diabetes 39:519-522.
19. Freinkel N, Younsi CE, Bonnar J, Dawson RMC. 1974. Rapid transient efflux of phosphate ions from pancreatic islets as an early action of insulin secretagogues. J Clin Invest 54:1179-1189.
20. Grampp GE, Lodish HF, Stephanopoulos G. 1997. Analysis of secretory dynamics and development of media for the controlled secretion of insulin-related peptides from βTC-3 insulinoma cells. Biotechnol Bioeng 53:274-282.
21. Hamaguchi K, Tatsumoto N, Fujii S, Okeda T, Nakamura M, Yamaguchi K, Fujimori O, Takaki R. 1986. Microencapsulation of pancreatic islets. A technique and its application to culture transplantation. Diabetes Res Clin Pract 2:337-345.
22. Hohmeier HE, Beltran-delRio H, Clark SA, Henkel-Reiger R, Normington K, Newgard CB. 1997. Regulation of insulin secretion from novel engineered insulinoma cell lines. Diabetes 46:968-977.
23. Hughes SD, Johnson JH, Quaade C, Newgard CB. 1992. Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells. Proc Natl Acad Sci USA 89:688-692.
24. 2 consumption in rat pancreatic islets. Diabetologia 18:395-405.
25. Knaack D, Fiore M. Surana M, Leiser M, Laurance M, Fusco-DeMane D. Hegre OD, Fletscher N, Efrat S. 1994. Clonal insulinomacell line that stably maintains correct glucose responsiveness. Diabetes 43: 1413-1417.
26. Kriat M, Fantini J, Viom-Dury J, Confort-Gouny S, Galons JP, Cozzonne PJ, 1992. Energetic metabolism of glucose, mannose and galactose in glucose starved rat insulinoma cells anchored on microcarrier beads. A phosphorous-31 NMR study. Biochimie 74:949-955.
27. Lacy PE, Hegre OD, Gerasimidi-Vazeou A, Gentile FT, Dionne KE. 1991. Maintenance of normoglycemia in diabetic mice by subcutaneous xenografts of encapsulated islets. Science 254:1782-1784.
28. Lanza RP, Bulter DH, Borland KM, Staruk JE, Faustman DL, Solomon BA, Muller TE, Rupp, RG. Maki T, Monaco AP, Chick WL. 1991. Xenotransplantation of canine, bovine, and porcine islets in diabetic rats without immunosuppression. Proc Natl Acad Sci USA 88:11100.
29. Lanza RP, Kühtreiber DM, Ecker JP, Marsh JE, Chick WL. 1996. Xeno-transplantation of bovine islets into dogs using biodegradable, injectable microreactors. Transplant Proc 28:820.
30. Lanza RP, Lodge P, Borland KM, Carretta M. Sullivan SJ, Beyer AM, Muller TE, Solomon, BA, Maki T, Monaco AP, Chick WL. 1993. Transplantation of islet allografts using a diffusion-based biohybrid artificial pancreas: long-term studies in diabetic, pancreatectomized dogs. Transplant Proc 25:978-980.
31. Liang Y, Bai G, Doliba N, Buettger C, Wang L, Berner DK, Matschinsky FM. 1996. Glucose metabolism and insulin release in mouse βHC9 cells, as model for wild-type pancreatic β-cells. Am J Physiol 270:E846-E857.
32. Liang Y, Matschinsky FM. 1994. Mechanisms of action of nonglucose insulin secretagogues. Annu Rev Nutr 14:59-81.
33. Lim F, Sun AM. 1980. Microencapsulated islets as hioartificial endocrine pancreas. Science 210:908-910.
34. 2+, oxygen consumption, and insulin secretion in glucose stimulated rat pancreatic islets. J Biol Chem 266:9314-9319.
35. Lyng H. Olsen DR, Petersen SB, Rofstad EK. 1995. 31PNMR spectroscopy studies of phospholipid metabolism in human melanoma xenograft lines differing in rate of tumour cell proliferation. Nucl Med Res Biomed 8:65-71.
36. Malaisse WJ, Best L, Kawazu S, Malaisse-Lagaae F, Sener A. 1983. The stimulus-secretion coupling of glucose-induced insulin release: fuel metabolism in islets deprived of nutrients. Arch Biochem Biophys 224:102-110.
37. Matschinsky FM. 1996. Banting Lecture 1995. A lesson in metabolic regu-lation inspired by the glucokinase glucose sensor paradigm. Diabetes 45:223-241.
38. Miyazaki J-I, Araki K. Yamato E, Ikegami H, Asano T, Shibasaki Y, Oka Y, Yamamura K-I. 1990. Establishment of a pancreatic βcell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127:126-132.
39. Mukundan NE, Flanders PC, Constantinidis I,Papas KK, Sambanis A. 1995. Rates of oxygen uptake by free and alginate entrapped βTC3 insulinoma cells. Biochem Biophys Res Commun 210:113-118.
40. O'Shea GM, Goosen, MFA, Sun AM. 1984. Prolonged survival of transplanted islets of Langerhans encapsulated in a biocompatible membrane. Biochim Biophys Acta 804:133-136.
41. Ohta M, Nelson D, Nelson J, Meglasson MD, Erecinska M. 1990. Oxygen and temperature dependence of stimulated insulin secretion in isolated rat islets of Langerhans. J Biol Chem 265:17525-17532.
42. i] by 2-deoxy-D-glucose. Biochem Pharmacol 43:1859-1864.
43. Panten U, Zunkler BJ, Scheit S, Kirchhoff K, Lenzen S. 1986. Regulation of energy metabolism in pancreatic islets by glucose and tolbutamide. Diabetologia 29:648-654.
44. Papas KK. 1996. Bioenergetics, metabolism and secretion of immunoisolated endocrine cell preparations. PhD thesis, Georgia Institute of Technology, Atlanta, GA, USA.
45. Papas KK, Constantinidis I, Sambanis A. 1993. Metabolic and secretory behavior of recombinant AtT-20 cells cultivated as free and entrapped spheroids. Cytotechnology 13:1-12.
46. 2 consumption in βHC9 cells. Am J Physiol 275:E1 100-E1 106.
47. Papas KK, Long RC Jr, Constantinidis I, Sambanis A. 1996. Effects of oxygen on the metabolic and secretory activities of βTC3 cells. Biochim Biophys Acta 1291:163-166.
48. i in the mechanism of insulin secretion in the mouse insulinoma βTC3 cell line. Biochem J 326:807-814.
49. Papas KK, Long RC Jr, Sambanis A, Constantinidis I. 1999. Towards the development of a bioartificial pancreas: II. Effects of oxygen on long-term entrapped βTC3 cell cultures. Biotechnol Bioeng 66:231-237.
50. Ricordi C, Digon BJ III, Mintz DH. Alejandro R. 1994. Human islet separation. In: Lanza RP, Chick WL, editors. Pancreatic islet transplantation. Vol I: Procurement of pancreatic islets. Austin, TX: RG Landes.
51. Ruiz-Cabello J, Cohen JS. 1992. Phospholipid metabolites as indicators of cancer cell function. Nucl Med Res Biomed 5:226-233.
52. Sambanis A. Papas KK, Flanders PC, Long RC Jr, Kang H, Constantinidis I. 1994. Towards the development of a bioartificial pancreas: immunoisolation and NMR monitoring of mouse insulinomas. Cytotechnology 15:351-363.
53. 31P NMR. J Magn Reson 65: 122-129.
54. Sener A, Blachier F, Malaisse WJ. 1988. Crabtree effect in tumoral pancreatic islet cells. J Biol Chem 263:1904-1909.
55. Sener A, Giroix MH, Hellestrom C. Malaisse WJ. 1987a. Influence of D-glucose upon the respiratory and secretory response of insulin-producing tumor cells to 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid. Cancer Res 47:5905-5907.
56. Sener A, Leclercq-Meyer V, Giroix MH, Malaisse WJ, Hellestrom C. 1987b. Opposite effects of D-glucose and a nonmetabolized analogue of L-leucine on respiration and secretion in insulin-producing tumoral cells (RINm5F). Diabetes 36:187-192.
57. Soon-Shiong P, Feldman E, Nelson R, Komtebedde J, Smidsrod O, Skjak-Braek G, Espevik T, Heintz R, Lee M. 1992. Successful reversal of spontaneous diabetes in dogs by intraperitoneal microencapsulated islets. Transplantation 54:769-774.
58. Soon-Shiong P, Heintz RE, Merideth N, Yao QX, Yao Z, Zheng T, Murphy M, Moloney MK, Schmehl M, Harris M, Mendez R, Mendex R, Sandford PA. 1994. Insulin independence in a type I diabetic patient after encapsulated islet transplantation. Lancet 343:950-951.
59. Sullivan SJ, Maki T, Carretta M, Ozato H, Borland K, Mahoney MD, Muller TE, Solomon BA, Monaco AP, Chick WL. 1992. Evaluation of the hybrid artificial pancreas in diabetic dogs. ASAIO J 38:29-33.
60. Sun AM, O'Shea GM. 1985. Microencapsulation of living cells - a long-term delivery system. J Controlled Rel 2:137-141.
61. Tziampazis E, Sambanis A. 1995. Tissue engineering of a bioartificial pancreas: modeling me cell environment and device function. Biotechnol Prog 11:115-126.