Medium chain triglycerides activate distal but not proximal gut hormones

Clinical Nutrition

Volumn 18, Issue 6, 1999, Pages 359-363

  Vu, M K ^a   Verkijk, M ^a   Muller, E S M ^a   Biemond, I ^a   Lamers, C B H W ^a   Masclee, A A M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cholecystokinin; Medium chain triglycerides; Peptide YY; Small intestinal transit

Indexed keywords

CHOLECYSTOKININ; DEUTERIUM; GASTROINTESTINAL HORMONE; LACTULOSE; LONG CHAIN TRIACYLGLYCEROL; MEDIUM CHAIN TRIACYLGLYCEROL; PEPTIDE YY; SODIUM CHLORIDE;

ABDOMINAL PAIN; ADULT; ARTICLE; BREATH ANALYSIS; CHOLECYSTOKININ BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DUODENUM; FEMALE; HUMAN; HUMAN EXPERIMENT; INTESTINE TRANSIT TIME; MALE; MUSCLE CRAMP; NAUSEA; NORMAL HUMAN; PROTEIN BLOOD LEVEL; RADIOIMMUNOASSAY; RANDOMIZED CONTROLLED TRIAL;

EID: 0033387574     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0261-5614(99)80016-8     Document Type: Article

References (22)

1. Timmermann F. Medium chain tryglycerides. The unconventional oil. Int Food Ingredients 1993; 3: 18-11
2. Bach A C, Babayan V K. Medium chain triglycerides: an update. Am J Clin Nutr 1982; 36: 950-962
3. Guillot E, Vaugelade P, Lemarchal P, Rerat A. Intestinal absorption and liver uptake of medium chain fatty acids in non-anaesthetized pigs. Br J Nutr 1993; 69: 431-432
4. Ruppin D C, Middleton W R J. Clinical use of medium chain triglycerides. Drugs 1980; 20: 216-224
5. Ladas S D, Isaacs PET, Murphy G M, Sladen G E. Comparison of the effects of medium and long chain triglyceride containing liquid meals on gallbladder and small intestinal function in normal man. Gut 1984; 25: 405-411
6. Hopman W P M, Jansen J B M W, Rosenbusch G, Lamers C B H W. Effect of equimolar amounts of long chain triglycerides and medium chain triglycerides on plasma cholecystokinin and gallbladder contraction. Am J Clin Nutr 1984; 39: 356-359
7. Isaacs PET, Ladas S, Forgacs I C, Dowling R H, Ellam S V, Adrian T E, Bloom S R. Comparison of effects of ingested medium and long chain triglyceride on gallbladder volume and release of cholecystokinin and other gut peptide. Dig Dis Sci 1987; 32: 481-486
8. Guimbaud R, Moreau J A, Bouisson M, Durand S, Escourrou J, Vaysse N, Frexinos J. Intraduodenal free fatty acids rather than triglycerides are responsible for the release of CCK in humans. Pancreas 1997; 14: 76-82
9. Hildebrand P, Petrig C, Burckhardt et al. Hydrolysis of dietary fat by pancreatic lipase stimulates cholecystokinin release. Gastroenterology 1998; 114: 123-129
10. Verkijk M, Vecht J, Gielkens H A J, Lamers C B H W, Masclee A A M. Effects of medium chain and long chain triglycerides on antroduodenal motility and small bowel transit time in man. Dig DisSci 1997; 42: 1933-1939
11. Ledeboer M, Masclee A A M, Jansen J B M J, Lamers C B H W. Effect of equimolar amounts of long chain triglycerides and medium chain triglycerides on small bowel transit time in human. JPEN 1995; 19: 5-8
12. Spiller R C, Trotman I F, Adrian T E, Bloom S R, Misiewicz J J, Silk DBA. Further characterisation of the ileal brake reflex in man effect of ileal infusion of partial digests of fat, protein, and starch on jejuna! motility and release of neurotensin, enteroglucagon, and peptide YY. Gut 1984; 29: 1042-1051
13. Pironi L, Stanghellini V, Miglioli M et al. Fat induced ileal brake in humans: a dose dependent phenomenon correlated to the plasma levels of peptide YY. Gastroenterology 1993; 105: 733-739.
14. Fone D R, Horowitz M, Read N W, Dent J, Maddox A. The effect of terminal ileal triglyceride infusion on gastroduodenal motility and intragastric distribution of a solid meal. Gastroenterology 1990; 98: 568-575
15. Bond J H, Levitt M D. Investigation of small bowel transit time in man utilizing pulmonary hydrogen (H2) measurements. J Lab Clin Med 1975; 85: 546-555.
16. Jansen J B MJ, Lamers C B H W. Molecular forms of cholecystokinin in plasma from normal and gastrectomized human subjects following a fat meal. Peptides 1987; 8: 801-805
17. Jansen J B M J, Lamers C B H W. Radioimmunoassay of cholecystokinin in human tissue and plasma. Clin Chim Acta 1983; 131: 305-316.
18. Solomon T E. Control of exocrine pancreatic secretion. In: Johnson L H, ed. Physiology of the gastrointestinal tract. Vol. 2, 3rd edn. New York: Raven, 1994: 1499-1529
19. Beardshall K, Morarji Y, Bloom S R, Frost G, Domin J, Calam J. Saturation of fat and cholecystokinin release: implications for pancreatic carcinogenesis. Lancet 1989; 1008-1010
20. Meyer J H, Jones R S. Canine pancreatic responses to intestinally perfused fat and products of fat digestion. Am J Physiol 1974; 226: 1178-1187
21. Keohane P P, Attrill H, Love M, Frost P, Silk D B. Relation between osmolality of diet and gastrointestinal side effects in enteral nutrition. Br Med J 1984; 288: 678-80
22. Hebuterne X, Ducrotte P, Denis P, Guedon C, Colin R, Lerebours E. Effects of intraduodenal and intravenous fat infusion on small bowel motiltity in humans. A comparative study of medium- and long- chain triglycerides. Eur J Gastroenterol Hepatol 1993; 5: 351-56